DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and zgc:136333

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_009303121.1	Gene:	zgc:136333 / 723999	ZFINID:	ZDB-GENE-060616-143	Length:	522	Species:	Danio rerio

Alignment Length:	517	Identity:	140/517 - (27%)
Similarity:	248/517 - (47%)	Gaps:	54/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ATAVNLEEA----KPYADIPGPSKLQLIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFRMP----- 82
            |.:|::::.    |..||:|......::...|..| |.| .:||:.:...:.||.:.::.
Zfish    36 AASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG-YLN-SIHELQIYQKQVYGPLSKINSGNLQ 98

  Fly    83 --SVAGTDLVLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGK 145
              |::..:|:        |.:.|.:.:||.|....:.    ..||.....||...|. .|..|.|
Zfish    99 GISISSVELL--------EELLRKDEKYPCRGYMTLW----TEHRDLRGIGYGPFTE-EGEKWYK 150

  Fly   146 MRTAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIRD-PVTQEMPDDFAVDIRHLVIESICSVA 209
            :|..:|..:|.|:::..|...:..|..:|::||..:|: ..|.::..:...::....:|.|.|:.
Zfish   151 LRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLEGIASIL 215

  Fly   210 LNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQLDIMPAFWKYLPMPNFKKLMRSLDTITDFCYF 274
            ..|.:|.| |:....:.|:.:.::..:......:.::|. |.....|.::|.:...|.|..|...
Zfish   216 FETRIGCL-EKEIPVETQEFINSIAQMFTYSMHVALLPN-WTRNYFPFWQKYIDGWDGIFKFGTK 278

  Fly   275 HIGNALKRIEEDAKAGTLNEIGLE--TSLLE--KLARFDRQTAVIIAMDLLFAGADPTLVTLGGI 335
            .|...::.|::  :..|..|:..|  |.||.  |::..|...:|   .:||.||.|.|..|:...
Zfish   279 MIDMKMEAIQK--RVDTNQEVAGEYLTYLLSSGKMSSKDVYGSV---SELLLAGVDTTSNTMLWA 338

  Fly   336 LFSLSKSPDKQARLLEEIRGILPNKDSSL-TIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPH- 398
            |:.|||.|..|..|.:|:..:|  ||..: |.|.:.::|:|:|.|||.:|:||:.|...|.:..
Zfish   339 LYLLSKDPAAQETLYQEVTKVL--KDDRIPTAEEVNSMPFLKAVIKETLRLYPVVPVNSRLIAET 401

  Fly   399 DVVLSGYRVVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDESNSHLVGET-ATPFMYLPFG 462
            :||:..|.....|...: .:|.:::.|:..|:.::|.|||||||       |.| ..||..:|||
Zfish   402 EVVIGEYFFPKKTTFNL-CHYAISHDEKVFPEPQKFKPERWLRD-------GRTRPNPFGSIPFG 458

  Fly   463 FGPRSCAGKRIVDMMLEIAISRLVRNFKIGFDYPIENAFKAQF--FVQPNIPFKFKFIERNE 522
            ||.|:|.|:||.::.:.:|::||::.|::..| |.....||.|  .:.||......|:||.:
Zfish   459 FGVRACVGRRIAELEMHLALARLIKLFEMRPD-PTVGEVKANFRSVLVPNKKVNLHFVERQK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	127/470 (27%)
zgc:136333	XP_009303121.1	p450	66..505	CDD:278495	129/471 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830