DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and cyp27c1

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001106808.2	Gene:	cyp27c1 / 558396	ZFINID:	ZDB-GENE-080204-68	Length:	540	Species:	Danio rerio

Alignment Length:	522	Identity:	132/522 - (25%)
Similarity:	247/522 - (47%)	Gaps:	70/522 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QKATAVNLEEAKPYADIPGPSKL-QLIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFR-------M 81
            |||..|     |...::||||.: .|:..|...|..:   :||:.::..::||.||:       :
Zfish    62 QKAARV-----KSLKEMPGPSTVANLLEFFYRDGFSR---IHEIQMEHAKKYGKIFKSRFGPQFV 118

  Fly    82 PSVAGTDLVLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKM 146
            .|:|..|:|..        :.|:|...|.|.:.|....::.:..|..     ||.|..|..|.||
Zfish   119 VSIADRDMVAQ--------VLRSESATPQRGNMESWKEYRDLRGRST-----GLISAEGDEWLKM 170

  Fly   147 RTAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIRDPVTQEMPDDFAVDIRHL----VIESICS 207
            |:.:..::::||:..::.:::..|..:.::|::.:|   :|:......::|..|    .:|.:.:
Zfish   171 RSVLRQLIMRPRDVAVFSSDVNDVVADLVKRVKTLR---SQQDDSQTVLNINDLFFKYAMEGVAT 232

  Fly   208 VALNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQLDI----MPAFWK-YLPMPNFKKLMRSLDT 267
            :...|.||.| |....|..|:.:.||. ::...|:..:    :|.:.: .:|.| :::...|.|.
Zfish   233 ILYETRLGCL-ENEIPKMSQEYITALH-LMFSSFKTTMYAGAIPKWLRPIIPKP-WEEFCSSWDG 294

  Fly   268 ITDFCYFHIGNALKRIE------EDAKAGTLNE--IGLETSLLEKLARFDRQTAVIIAMDLLFAG 324
            :..|...|:...|..|:      |:.|.|.|..  :..|.:|.|..|..         .::|.||
Zfish   295 LFKFSQIHVDKRLSEIKKQMEKSEEIKGGLLTHMLVTREMNLEEIYANM---------TEMLLAG 350

  Fly   325 ADPTLVTLGGILFSLSKSPDKQARLLEEIRGILPNKDSSLTIENMRNLPYLRACIKEGIRMYPIG 389
            .|.|..||....:.|::.|..|.::.||:..:|..:..  |.|::..||.:|..:||.:|::|:.
Zfish   351 VDTTSFTLSWSTYLLARHPTIQQQIFEEVDRVLGGRVP--TGEDVPYLPLIRGLVKETLRLFPVL 413

  Fly   390 PGTLRRMPHDVVLSGYRVVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDESNSHLVGETAT 454
            ||..|....|:::.||.:..||.:.: .:|..:..|:..|:..||.|:||:|.:::     :...
Zfish   414 PGNGRVTHDDLIVGGYLIPKGTQLAL-CHYSTSMDEENFPRPEEFRPDRWIRKDAS-----DRVD 472

  Fly   455 PFMYLPFGFGPRSCAGKRIVDMMLEIAISRLVRNFKIGFD-YPIENAFKAQFFVQPNIPFKFKFI 518
            .|..:|||:|.|||.|:||.::.:.:|:::|::||.|... ...|...|....:.|......:|.
Zfish   473 NFGSIPFGYGIRSCIGRRIAELEMHLALTQLLQNFHIEVSPQTTEVHAKTHGLLCPGASINLRFT 537

  Fly   519 ER 520
            :|
Zfish   538 DR 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	118/478 (25%)
cyp27c1	NP_001106808.2	p450	74..517	CDD:306555	122/481 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830