Protein Alignment Cyp12e1 and Cyp49a1

DIOPT Version :9

• Sequence 1: NP_650003.4
• Gene: Cyp12e1 / 41272
• FlyBaseID: FBgn0037817
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_001246256.1
• Gene: Cyp49a1 / 36105
• FlyBaseID: FBgn0033524
• Length: 589
• Species: Drosophila melanogaster
• Alignment Length: 511
• Identity: 151/511 - (29%)
• Similarity: 273/511 - (53%)
• Gaps: 17/511 - (3%)

  Fly    23 LAQKATAVNLEEAKPYADIPGPSKLQLIR---AFLP-GGLYKNLPVHEMFLDMNRQYGSIFRMPS 83
            |..:.|:......:||:::|||..|.||.   .|.| .|.||...:.::..:::..||.:.::..
  Fly    85 LPAETTSSPAAAVRPYSEVPGPYPLPLIGNSWRFAPLIGTYKISDLDKVMNELHVNYGKMAKVGG 149

  Fly    84 VAG-TDLVLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKMR 147
            :.| .||:...:..:...||:.|...|:|.|...:.::|...||:.|....||...:||.|...|
  Fly   150 LIGHPDLLFVFDGDEIRNIFKKEEAMPHRPSMPSLRHYKGDLRRDFFGDVAGLIGVHGPKWEAFR 214

  Fly   148 TAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIRDPVTQEMPDDFAVDIRHLVIESICSVALNT 212
            ..|..|||||:.||.|:..|..::.||:.||.::||. ..|:|.:|..::....:||:..|:|:|
  Fly   215 QEVQHILLQPQTAKKYIPPLNDIASEFMGRIELMRDE-KDELPANFLHELYKWALESVGRVSLDT 278

  Fly   213 HLGLLGEQRNNKDIQKLVLALQDVVELGFQLDIMPAFWKYLPMPNFKKLMRSLDTITDFCYFHIG 277
            .||.|..: .:::.|:::.|:........:|::....|:..|...::..:::||..|..|..:||
  Fly   279 RLGCLSPE-GSEEAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSFVKALDQFTAICMKNIG 342

  Fly   278 NALKRIEEDAKAGTLNEIGLETSLLEKLAR--FDRQTAVIIAMDLLFAGADPTLVTLGGILFSLS 340
            ..:.:.:.|...| |::...:.|::|::.|  .:|:.|.|:|:||...|.|.|.|.....::.|:
  Fly   343 KTMDKADADEARG-LSKSEADISIVERIVRKTGNRKLAAILALDLFLVGVDTTSVAASSTIYQLA 406

  Fly   341 KSPDKQARLLEEIRGILPNKDSSLTIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVLSGY 405
            |:||||.:|.:|::.:.|::::.:....:..:||||||:||.:||.|:.....|.:..|.|::||
  Fly   407 KNPDKQKKLFDELQKVFPHREADINQNVLEQMPYLRACVKETLRMRPVVIANGRSLQSDAVINGY 471

  Fly   406 RVVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDESNS----HLVGETATPFMYLPFGFGPR 466
            .|..||.| |..:..::|...:.|:.:.|:|||||:..:::    | ..:...||:.||||||.|
  Fly   472 HVPKGTHV-IFPHLVVSNDPAYFPEPKRFLPERWLKQSTDAAGCPH-ANQKIHPFVSLPFGFGRR 534

  Fly   467 SCAGKRIVDMMLEIAISRLVRNFKIGFDYPIENAFKAQFFVQPNIPFKFKFIERNE 522
            .|.|:|..::.|...::::.|.:|:.::.. |..::......|..|..||...|:|
  Fly   535 MCVGRRFAEIELHTLLAKIFRKYKVSYNSG-EFVYRVNSTYIPQSPLNFKLTLRDE 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	133/460 (29%)
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	140/466 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I1783
eggNOG	1	0.900	-	-		E2759_KOG0159
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	1	1.000	-	-		FOG0000720
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
	9	8.970