DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and CYP27C1

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001354431.1	Gene:	CYP27C1 / 339761	HGNCID:	33480	Length:	537	Species:	Homo sapiens

Alignment Length:	517	Identity:	137/517 - (26%)
Similarity:	234/517 - (45%)	Gaps:	70/517 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EEAKPYADIPGPSKL-QLIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFR-------MPSVAGTDL 89
            |..:..|.:|||..| .|...|...|..:   :||:.....|:||.||:       :.|:|..|:
Human    61 EGPRSLAAMPGPRTLANLAEFFCRDGFSR---IHEIQQKHTREYGKIFKSHFGPQFVVSIADRDM 122

  Fly    90 VLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKMRTAVNPIL 154
            |..        :.|.||..|.|.:.|....::.:..|..     ||.|..|..|.|||:.:...:
Human   123 VAQ--------VLRAEGAAPQRANMESWREYRDLRGRAT-----GLISAEGEQWLKMRSVLRQRI 174

  Fly   155 LQPRNAKLYMTNLVQVSDEFLERIRIIRDPVTQEMPDDFAVDIRHLV----IESICSVALNTHLG 215
            |:|::..:|...:.||..:.::||.::|   :|....:...::..|.    :|.:.::...:.||
Human   175 LKPKDVAIYSGEVNQVIADLIKRIYLLR---SQAEDGETVTNVNDLFFKYSMEGVATILYESRLG 236

  Fly   216 LLGEQRNNKDIQKLVLALQDVVELGFQL-------DIMPAFWK-YLPMPNFKKLMRSLDTITDFC 272
            .|     ...|.:|.:...:.:||.|.:       ..:|.:.: ::|.| :::..||.|.:..|.
Human   237 CL-----ENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKP-WREFCRSWDGLFKFS 295

  Fly   273 YFHIGNALKRIEEDAKAGTLNEIGLETSLLEKLARFDRQTAVIIAMDLLFAGADPTLVTLGGILF 337
            ..|:.|.|:.|:.....|.....||.|.|....| ...|.......::|.||.|.|..||...::
Human   296 QIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQA-LTLQEIYANVTEMLLAGVDTTSFTLSWTVY 359

  Fly   338 SLSKSPDKQARLLEEIRGILPNKDSSLTIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVL 402
            .|::.|:.|..:..||...|..:... |..::..:|.:||.:||.:|::|:.||..|....|:|:
Human   360 LLARHPEVQQTVYREIVKNLGERHVP-TAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVI 423

  Fly   403 SGYRVVAGTDVGI---AANYQMANMEQFVPKVREFIPERWLR----DESNSHLVGETATPFMYLP 460
            .||.:..||.:.:   |.:||..|.    |:.:||.||||||    |..::         |..:|
Human   424 GGYLIPKGTQLALCHYATSYQDENF----PRAKEFRPERWLRKGDLDRVDN---------FGSIP 475

  Fly   461 FGFGPRSCAGKRIVDMMLEIAISRLVRNFKIGFDYPIENAF--KAQFFVQPNIPFKFKFIER 520
            ||.|.|||.|:||.::.:.:.:.:|:::|:|..... .||.  |....:.|..|...:|:.|
Human   476 FGHGVRSCIGRRIAELEIHLVVIQLLQHFEIKTSSQ-TNAVHAKTHGLLTPGGPIHVRFVNR 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	126/481 (26%)
CYP27C1	NP_001354431.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	194	1.000	Domainoid score	I3171
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	201	1.000	Inparanoid score	I3768
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.880