DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	484	Identity:	112/484 - (23%)
Similarity:	190/484 - (39%)	Gaps:	107/484 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 VHEMFLDMNRQYGSIF--RMPSVAGTDLVLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRR 126
            ::|.:.|.:...| :|  |:|.      :|.|.|:....|:..:     .|||...::...|:::
  Fly    63 IYEKYKDTDNMVG-VFTTRVPQ------LLVMCPEYIHKIYATD-----FRSFHNNEWRNFVNKK 115

  Fly   127 EVFDGYDGLTSGNGP------AWGKMRTAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIRDPV 185
                  ..:..||.|      .|.:.|:.:.| .|.|...|........|..:|:|.||..:...
  Fly   116 ------TDMILGNNPFVLTGDEWKERRSEIMP-ALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMA 173

  Fly   186 TQEMPDDFAVDIRHLVIESIC---SVALNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQL---D 244
            |.|..|  |:|:      |:|   .|..:..||:..:...:.. ..|:..::.|....|:.   .
  Fly   174 TSEGLD--AMDL------SLCYTTEVVSDCGLGVSAQSFTDTP-TPLLKMIKRVFNTSFEFIFYS 229

  Fly   245 IMPAFW----KYLPMPNFKK--------LMRSLDTI---------TDFCYFHIGNALKRIEEDAK 288
            ::...|    |:..:|.|.|        ::|...|:         .||.     |.:.:::|
  Fly   230 VVTNLWQKVRKFYSVPFFNKETEVFFLDIIRRCITLRLEKPEQQRDDFL-----NYMLQLQE--- 286

  Fly   289 AGTLNEIGLETSLLEKLARFDRQTAVIIAMDLLFAGADPTLVTLGGILFSLSKSPDKQARLLEEI 353
                 :.||.|           ...:|..|..:..|.:.|.:.|..|:..|.::|::|.::.:||
  Fly   287 -----KKGLHT-----------DNILINTMTFILDGFETTALVLAHIMLMLGRNPEEQDKVRKEI 335

  Fly   354 RGILPNKDSSLTIENMRNLPYLRACIKEGIRMY--PIGPGTLRRMPHDVVLSGYRVV---AGTDV 413
                  ..:.||.:.|..||:|.|||.|.:|::  .:....|...|.:......|.|   .|..|
  Fly   336 ------GSADLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPFEFANKNGRTVHLKPGDVV 394

  Fly   414 GIAANYQMANMEQFVPKVREFIPERWLRDESNSHLVGETATPFMYLPFGFGPRSCAGKRIVDMML 478
            .|... .:.:..|:......|.|||:|  |||...:.......:||.||.|||.|.|.|.....|
  Fly   395 TIPVK-ALHHDPQYYEDPLTFKPERFL--ESNGGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQL 456

  Fly   479 EIAISRLVRNFKIGF------DYPIENAF 501
            :.|:..::|||:|..      |..|::.|
  Fly   457 KAALVEILRNFEIKVNPKTRSDNQIDDTF 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	112/484 (23%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	109/472 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910