DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and cyp27a1.4

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001315442.1	Gene:	cyp27a1.4 / 322341	ZFINID:	ZDB-GENE-030131-1060	Length:	522	Species:	Danio rerio

Alignment Length:	529	Identity:	138/529 - (26%)
Similarity:	248/529 - (46%)	Gaps:	78/529 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ATAVNLEEA----KPYADIPGPSKLQLIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFRMP----- 82
            |.:|::::.    |..||:|......::...|..| |.| .|||:.|...:.||.::::.
Zfish    36 AASVSVQDGHRKLKTEADLPEIKIFTMLYQMLFKG-YLN-SVHELQLYQKQVYGPLWKINAGNLQ 98

  Fly    83 --SVAGTDLVLTMNPQDYEVIFRNEGQYPYR---------RSFEVMDYFKRVHRREVFDGYDGLT 136
              |:...:|:        |.:.|.:.:||.|         |....:.|              |..
Zfish    99 GISITSVELL--------EELLRKDEKYPCRGYMTLWTEHRDLRGISY--------------GPF 141

  Fly   137 SGNGPAWGKMRTAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIRD-PVTQEMPDDFAVDIRHL 200
            :..|..|.|:|..:|..:|.|:::..|...:..|..:|::||..:|: ..|.::..:...::...
Zfish   142 TEEGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRF 206

  Fly   201 VIESICSVALNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQLDIMPAFWK-YLPMPNFKKLMRS 264
            .:|.|.|:...|.:|.| |:....:.|:.:.::..:......:.::|.:.: |||.  ::|.:..
Zfish   207 SLEGIASILFETRIGCL-EKEIPAETQEFINSIAQMFTYNMHVALLPNWTRNYLPF--WQKYIDG 268

  Fly   265 LDTITDFCYFHIGNALKRIEEDA---KAGTLNEIGLE--TSLLE--KLARFDRQTAVIIAMDLLF 322
            .|.|     |..|..:..::.:|   :..|..|:..|  |.||.  |::..|...:|   .::|.
Zfish   269 WDGI-----FKFGTKMINLKMEAIQTRLDTNQEVAGEYLTYLLSSGKMSCKDVYGSV---SEVLL 325

  Fly   323 AGADPTLVTLGGILFSLSKSPDKQARLLEEIRGILPNKDSSLTIENMRNLPYLRACIKEGIRMYP 387
            ||.|.|..|:...|:.|||.|..|..|.:|:..:|.. |...|.|.:.::|:|:|.|||.:|:||
Zfish   326 AGVDTTSNTMLWALYLLSKDPAAQETLHQEVTKVLKG-DRIPTAEEVNSMPFLKAVIKETLRLYP 389

  Fly   388 IGPGTLRRMPH-DVVLSGYRVVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDESNSHLVGE 451
            :.|...|.:.. :|::..|.....|...: .:|.:::.|:..|:.::|.|||||||       |.
Zfish   390 VVPVNSRLIAESEVIIGEYLFPKKTTFNL-FHYAISHDEKVFPEPQKFKPERWLRD-------GR 446

  Fly   452 T-ATPFMYLPFGFGPRSCAGKRIVDMMLEIAISRLVRNFKIGFDYPIENAFKAQF--FVQPNIPF 513
            | ..||..:|||||.|:|.|:||.::.:.:|::||::.|::..| |.....||.|  .:.||...
Zfish   447 TRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPD-PTVGEVKANFRSVLVPNKKV 510

  Fly   514 KFKFIERNE 522
            ...|:||.:
Zfish   511 NLHFVERQK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	125/482 (26%)
cyp27a1.4	NP_001315442.1	p450	66..505	CDD:278495	127/483 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6352
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830