DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and Cyp11a1

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_058982.1	Gene:	Cyp11a1 / 29680	RGDID:	69325	Length:	526	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	123/505 - (24%)
Similarity:	219/505 - (43%)	Gaps:	63/505 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KPYADIPGPSK---LQLIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFRMPSVAGTDLVLTMNPQD 97
            :.:.:||.|..   :.|.......|.::   :|...:...::||.|:| ..:...:.|..::|:|
  Rat    44 RSFNEIPSPGDNGWINLYHFLRENGTHR---IHYHHMQNFQKYGPIYR-EKLGNMESVYILDPKD 104

  Fly    98 YEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKMRTAVNPILLQPRNAKL 162
            ...:|..||..|.|........:.:.::|.:     |:...:..||.|.|..:|..::.|.:.|.
  Rat   105 AATLFSCEGPNPERYLVPPWVAYHQYYQRPI-----GVLFKSSDAWRKDRIVLNQEVMAPDSIKN 164

  Fly   163 YMTNLVQVSDEFLERI-RIIRDPVTQEMPDDFAVDIRHLVIESICSVALNTHLGLLGEQRNNKDI 226
            ::..|..|:.:|::.: |.|:...:.:...|.:.|:.....|||.||.....||:| |:..:.:.
  Rat   165 FVPLLEGVAQDFIKVLHRRIKQQNSGKFSGDISDDLFRFAFESITSVVFGERLGML-EEIVDPES 228

  Fly   227 QKLVLALQDVVELGFQLDIMPAFWKYLPMPNFKKLMRS----------------LDTITDFCYFH 275
            |:.:.|:..:......:..||        |:..:|.|:                .|..|...|:.
  Rat   229 QRFIDAVYQMFHTSVPMLNMP--------PDLFRLFRTKTWKDHAAAWDVIFSKADEYTQNFYWD 285

  Fly   276 IGNALKRIEEDAKAGTLNEIGLETSLL--EKLARFDRQTAVIIAMDLLFAGADPTLVTLGGILFS 338
                |::..:.:|..     |:..|||  .||...:.|..:   .::|..|.|.|.:||...|:.
  Rat   286 ----LRQKRDFSKYP-----GVLYSLLGGNKLPFKNIQANI---TEMLAGGVDTTSMTLQWNLYE 338

  Fly   339 LSKSPDKQARLLEEIRGILPNKDSSLTIENMRNL-PYLRACIKEGIRMYPIGPGTLRRMPHDVVL 402
            ::.:...|..|..|:  :...:.:...:..|..| |.|:|.|||.:|::||.....|.:.:|:||
  Rat   339 MAHNLKVQEMLRAEV--LAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQRYIVNDLVL 401

  Fly   403 SGYRVVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDESNSHLVGETATPFMYLPFGFGPRS 467
            ..|::.|.|.|.: |:|.|.....|.|...:|.|.|||....|:       |.|.||.||:|.|.
  Rat   402 RNYKIPAKTLVQV-ASYAMGRESSFFPNPNKFDPTRWLEKSQNT-------THFRYLGFGWGVRQ 458

  Fly   468 CAGKRIVDMMLEIAISRLVRNFKIGFDYPIENAFKAQFFVQPNIPFKFKF 517
            |.|:||.::.:.|.:..::.||:|......:...|....:.|..|..|.|
  Rat   459 CLGRRIAELEMTIFLINVLENFRIEVQSIRDVGTKFNLILMPEKPIFFNF 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	117/473 (25%)
Cyp11a1	NP_058982.1	cytochrome_P450	80..505	CDD:425388	115/461 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820