DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and CYP11A1

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_000772.2	Gene:	CYP11A1 / 1583	HGNCID:	2590	Length:	521	Species:	Homo sapiens

Alignment Length:	506	Identity:	118/506 - (23%)
Similarity:	220/506 - (43%)	Gaps:	34/506 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KATAVNLEEAKPYADIPGPSK---LQLIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFRMPSVAGT 87
            :...::....:|:.:||.|..   |.|...:...|.:|   ||...:...::||.|:| ..:...
Human    36 EGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHK---VHLHHVQNFQKYGPIYR-EKLGNV 96

  Fly    88 DLVLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKMRTAVNP 152
            :.|..::|:|..::|::||..|.|........:.:.::|.:     |:......||.|.|.|:|.
Human    97 ESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI-----GVLLKKSAAWKKDRVALNQ 156

  Fly   153 ILLQPRNAKLYMTNLVQVSDEFLERI-RIIRDPVTQEMPDDFAVDIRHLVIESICSVALNTHLGL 216
            .::.|...|.::..|..||.:|:..: |.|:...:.....|.:.|:.....|||.:|......|:
Human   157 EVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGM 221

  Fly   217 LGEQRNNKDIQKLVLALQDVVELGF-QLDIMPAFWKYLPMPNFKKLMRSLDTITDFCYFHIGNAL 280
            | |:..|.:.|:.:.|:..:..... .|::.|..::......:|..:.:.|.|......:..|..
Human   222 L-EEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFY 285

  Fly   281 KRIEEDAKAGTLNE--IGLETSLL--EKLARFDRQTAVIIAMDLLFAGADPTLVTLGGILFSLSK 341
            ..:.:   .|:::.  .|:...||  .|::..|.:..|   .::|..|.|.|.:||...|:.:::
Human   286 WELRQ---KGSVHHDYRGILYRLLGDSKMSFEDIKANV---TEMLAGGVDTTSMTLQWHLYEMAR 344

  Fly   342 SPDKQARLLEEIRGILPNKDSSLTIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVLSGYR 406
            :...|..|..|:..........:. ..::.:|.|:|.|||.:|::||.....|.:.:|:||..|.
Human   345 NLKVQDMLRAEVLAARHQAQGDMA-TMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYM 408

  Fly   407 VVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDESNSHLVGETATPFMYLPFGFGPRSCAGK 471
            :.|.|.|.:|. |.:.....|......|.|.|||..:.|       .|.|..|.||:|.|.|.|:
Human   409 IPAKTLVQVAI-YALGREPTFFFDPENFDPTRWLSKDKN-------ITYFRNLGFGWGVRQCLGR 465

  Fly   472 RIVDMMLEIAISRLVRNFKIGFDYPIENAFKAQFFVQPNIPFKFKFIERNE 522
            ||.::.:.|.:..::.||::...:..:........:.|..|..|.|...|:
Human   466 RIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQ 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	108/459 (24%)
CYP11A1	NP_000772.2	p450	52..511	CDD:278495	114/483 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8467
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820