DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and Cyp27b1

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_034139.2	Gene:	Cyp27b1 / 13115	MGIID:	1098274	Length:	507	Species:	Mus musculus

Alignment Length:	475	Identity:	142/475 - (29%)
Similarity:	210/475 - (44%)	Gaps:	57/475 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ADIPGPSKLQ-LIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFRMPSVAGTDLVLTMNPQDYEVIF 102
            :||||||.|. |...|..|||.:   :||:.:....:||.|: ..|......|...:|...|.:.
Mouse    38 SDIPGPSTLSFLAELFCKGGLSR---LHELQVHGAARYGPIW-SGSFGTLRTVYVADPTLVEQLL 98

  Fly   103 RNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKMRTAVNPILLQPRNAKLYMTNL 167
            |.|...|.|.||......:|.|:|..     ||.:.:|..|.::|:.:.|:||:|:.|..|...|
Mouse    99 RQESHCPERCSFSSWAEHRRRHQRAC-----GLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTL 158

  Fly   168 VQVSDEFLERIRIIRDPVTQEMPD---DFAVDIRHLVIESICSVALNTHLGLLGEQRNNKDIQKL 229
            ..|..:.:.|:|..|.. ...:|.   |.|.:.....:|||.:|.|.:.||.| |.....|.:..
Mouse   159 DNVVRDLVRRLRRQRGR-GSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGCL-EAEVPPDTETF 221

  Fly   230 VLALQDVVELGFQLDIMPAFWKYLPMPNFKKLMRSLDTITDFCYFHI----GNALKR----IEED 286
            :.|:..|.........||.:..:|....:.:|.|..|.:..|...|:    |.|..|    .|||
Mouse   222 IHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEED 286

  Fly   287 AKAGTLNEIGLETSLLEKLARF------DRQTAVIIAMDLLFAGADPTLVTLGGILFSLSKSPDK 345
            ..:|            ..|..|      ..|:.|....:||.||.|....||...|:.||:.||.
Mouse   287 MPSG------------HHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDV 339

  Fly   346 QARLLEEI----RGILPNKDSSLTIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVLSGYR 406
            |..|..||    ||...:...:.    :..||.|:|.|||.:|:||:.||..|....|:.:..|.
Mouse   340 QTALHSEITAGTRGSCAHPHGTA----LSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYV 400

  Fly   407 VVAGTDVGIAANYQMANMEQFVPKVREFIPERWLRDESNSHLVGETATPFMYLPFGFGPRSCAGK 471
            :...|.|.:.......:..|| |....|.|.|||.:       |.|..||..||||||.|||.|:
Mouse   401 IPQDTLVSLCHYATSRDPTQF-PDPNSFNPARWLGE-------GPTPHPFASLPFGFGKRSCIGR 457

  Fly   472 RIVDMMLEIAISRLVRNFKI 491
            |:.::.|::|:|:::.:|::
Mouse   458 RLAELELQMALSQILTHFEV 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	130/450 (29%)
Cyp27b1	NP_034139.2	p450	41..504	CDD:278495	140/472 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	1	0.950	-	0	Normalized mean entropy	S4820
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.830