DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp12e1 and Cyp27b1

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_446215.1	Gene:	Cyp27b1 / 114700	RGDID:	69192	Length:	501	Species:	Rattus norvegicus

Alignment Length:	477	Identity:	142/477 - (29%)
Similarity:	213/477 - (44%)	Gaps:	60/477 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ADIPGPSKLQ-LIRAFLPGGLYKNLPVHEMFLDMNRQYGSIFRMPSVAGTDLVLTMNPQDYEVIF 102
            :||||||... |...|..|||.:   :||:.:....:||.|: ..|......|...:|...|.:.
  Rat    31 SDIPGPSTPSFLAELFCKGGLSR---LHELQVHGAARYGPIW-SGSFGTLRTVYVADPALVEQLL 91

  Fly   103 RNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSGNGPAWGKMRTAVNPILLQPRNAKLYMTNL 167
            |.|...|.|.||......:|.|:|..     ||.:.:|..|.::|:.:.|:||:|:.|..|...|
  Rat    92 RQESHCPERCSFSSWSEHRRRHQRAC-----GLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTL 151

  Fly   168 VQVSDEFLERIRIIRDPVTQEMPD---DFAVDIRHLVIESICSVALNTHLGLLGEQRNNKDIQKL 229
            ..|..:.:.|:|..|.. ...:||   |.|.:.....:|.|.:|.|.:.||.| |.....|.:..
  Rat   152 DSVVSDLVRRLRRQRGR-GSGLPDLVLDVAGEFYKFGLEGIGAVLLGSRLGCL-EAEVPPDTETF 214

  Fly   230 VLALQDVVELGFQLDIMPAFW--KYLPMPNFKKLMRSLDTITDFCYFHI----GNALKR----IE 284
            :.|:..|.........||: |  :.:|.| :.:|.|..|.:..|...|:    |.|..|    .|
  Rat   215 IEAVGSVFVSTLLTMAMPS-WLHRLIPGP-WARLCRDWDQMFAFAQKHVEQREGEAAVRNQGKPE 277

  Fly   285 EDAKAGTLNEIGLETSLLEKLARF------DRQTAVIIAMDLLFAGADPTLVTLGGILFSLSKSP 343
            ||...|            ..|..|      ..|:.|....:||.||.|....||...|:.||:.|
  Rat   278 EDLPTG------------HHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNTLSWALYELSRHP 330

  Fly   344 DKQARLLEEIRG-ILPNKDSSLTIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVLSGYRV 407
            :.|:.|..||.| :.|...:.|....:..||.|:|.|||.:|:||:.||..|....|:.:..|.:
  Rat   331 EVQSALHSEITGAVNPGSYAHLQATALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDICVGNYVI 395

  Fly   408 VAGTDVGIAANYQMANMEQFVPKVRE---FIPERWLRDESNSHLVGETATPFMYLPFGFGPRSCA 469
            ...|.|.:.......:..||    ||   |.|.|||.:       |....||..||||||.|||.
  Rat   396 PQDTLVSLCHYATSRDPAQF----REPNSFNPARWLGE-------GPAPHPFASLPFGFGKRSCI 449

  Fly   470 GKRIVDMMLEIAISRLVRNFKI 491
            |:|:.::.|::|:::::.:|::
  Rat   450 GRRLAELELQMALAQILTHFEV 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	131/452 (29%)
Cyp27b1	NP_446215.1	CYP27B1	61..496	CDD:410741	129/444 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3706
OMA	1	1.010	-	-		QHG48087
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8942
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880