DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp12e1 and Cyp11b1

DIOPT Version :9

Sequence 1:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001028401.2	Gene:	Cyp11b1 / 110115	MGIID:	88583	Length:	501	Species:	Mus musculus

Alignment Length:	512	Identity:	130/512 - (25%)
Similarity:	222/512 - (43%)	Gaps:	75/512 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LSTQWNANKQISRQIYQLCRGLAQKATAVNLEEAKPYADIPGPSK------LQLIRAFLPGGLYK 60
            |:..|        |.....|.|...||... :..:|:..||..|:      :|::|.  .|....
Mouse    13 LARPW--------QCLHRTRALGTTATLAP-KTLQPFEAIPQYSRNKWLKMIQILRE--QGQENL 66

  Fly    61 NLPVHEMFLDMNRQYGSIFRMPSVAGTDLVLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHR 125
            :|.:|::|    |:.|.||| .||..|.:|....|:|.|.:::.|..:|.|...|..    .|||
Mouse    67 HLEMHQVF----RELGPIFR-HSVGKTQIVFVTLPEDVEKLYQVESTHPCRMPLESW----IVHR 122

  Fly   126 REVFDGYDGLTSG----NGPAWGKMRTAVNPILLQPRNAKLYMTNLVQVSDEFLERI-RIIRDPV 185
            .     ..||..|    |||.|...|..:||.:|.|:..:.::..:..::.:|::.: :.:.:.|
Mouse   123 E-----LRGLGRGVFLLNGPEWYFNRLQLNPNVLSPKAVQKFVPLVDGIARDFVDNLKKKMLESV 182

  Fly   186 TQEMPDDFAVDIRHLVIESICSVALNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQLDIMP-AF 249
            ......||...:.:..||:...|.....|||:|... :.|..|.:..|..:.:...||..:| :.
Mouse   183 HGSFSMDFQSSVFNYTIEASHFVLFGERLGLIGRDL-SPDSLKFLHTLHSMFKTTTQLLYLPRSL 246

  Fly   250 WKYLPMPNFKKLMRSLDTITDFCYFHIGNALKRIEEDAKAGTLNEIGLETSLL-EKLARFDRQTA 313
            .::.....:|:.:.|.|.|:::    :...:|.:..:...|......:...|: |:....|...|
Mouse   247 TRWTSTRVWKENLESWDFISEY----VTKCIKNVYRELAEGRPQSWSVTAELVAERTLSMDAIQA 307

  Fly   314 VIIAMDLLFAGADPTLVTLGGILFSLSKSPDKQARLLEEIRGILPNKDSSLTIE---------NM 369
              .:|:|:....|.|...|....|.|:::||.|..|.:|          ||..|         .|
Mouse   308 --NSMELIAGSTDTTSTPLVMTFFELARNPDVQQALRQE----------SLAAEASIAANPQKAM 360

  Fly   370 RNLPYLRACIKEGIRMYPIGPGTLRRMPHDVVLSGYRVVAGTDVGIAANYQMANMEQFVPKVREF 434
            .:||.|||.:||.:|:||:|....|.:..|:||..|.|.|||.:.:.. |.|.......|:...:
Mouse   361 SDLPLLRAALKETLRLYPVGTFLERILSSDLVLQNYHVPAGTVLNVNL-YSMGRNPAVFPRPERY 424

  Fly   435 IPERWLRDESNSHLVGETATPFMYLPFGFGPRSCAGKRIVDMMLEIAISRLVRNFKI 491
            :|:|||          |....|.:|.||||.|.|.|:|:.:..:.:.:..::::|.:
Mouse   425 MPQRWL----------ERKRSFKHLAFGFGVRQCLGRRLAEAEMMLLLHHVLKSFHV 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	115/445 (26%)
Cyp11b1	NP_001028401.2	p450	44..497	CDD:278495	121/472 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D185685at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820