Protein Alignment Cyp12e1 and Cyp27a1

DIOPT Version :9

• Sequence 1: NP_650003.4
• Gene: Cyp12e1 / 41272
• FlyBaseID: FBgn0037817
• Length: 522
• Species: Drosophila melanogaster
• Sequence 2: NP_077226.2
• Gene: Cyp27a1 / 104086
• MGIID: 88594
• Length: 533
• Species: Mus musculus
• Alignment Length: 551
• Identity: 153/551 - (27%)
• Similarity: 252/551 - (45%)
• Gaps: 90/551 - (16%)

  Fly    19 LC-RGLAQKAT---AVNLEEA-------------KPYADIPGPSKLQ-LIRAFLPGGLYKNLPVH 65
            || :|...|||   |:..:|:             :..|::||...|| |.:.||.|.:. :||..
Mouse    23 LCPQGARAKATIPAALQAQESTEGPGTGQDRPRLRSPAELPGTGTLQFLFQLFLQGYVL-HLPDL 86

  Fly    66 EMFLDMNR-QYGSIFRMPSVAGTDLVLTMNPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVF 129
            ::   :|: :||.::.......|::.|...|. .|.:.|.||:||.|   :.||.:|. ||
Mouse    87 QV---LNKTKYGPMWTTSFGTYTNVNLASAPL-LEQVMRQEGKYPIR---DHMDQWKD-HR---- 139

  Fly   130 DGYDGLTSG----NGPAWGKMRTAVNPILLQPRNAKLYMTNLVQVSDEFLERIRIIR-DPVTQEM 189
             .:.|||.|    .|..|..:|.|:...||:|..|.||...|.:|..:|:.|:..:| :..:.:.
Mouse   140 -DHKGLTYGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDALNEVISDFITRLDQVRAESESGDQ 203

  Fly   190 PDDFAVDIRHLVIESICSVALNTHLGLLGEQRNNKDIQKLVLALQDVVELGFQLDIMPAF---WK 251
            ..|.|..:.||.:|:|..:.....:|.|     ...|.:...|....|.:.||..:...|   |.
Mouse   204 VPDMAHLLYHLALEAITYILFEKRIGCL-----KPSIPEDTAAFIRSVAIMFQNSVYITFLPKWT 263

  Fly   252 YLPMPNFKKLMRSLDTITDFCYFHIGNAL--KRIEEDAKAGTLNEIG---------LETSLLEKL 305
            ...:|.:|:.:...|.|     |..|..|  ::::| .|| .|.|.|         |...|..:|
Mouse   264 RPLLPFWKRYLNGWDNI-----FSFGKKLIDEKVQE-LKA-QLQETGPDGVRVSGYLHFLLTNEL 321

  Fly   306 ARFDRQTAVIIAMDLLFAGADPTLVTLGGILFSLSKSPDKQARLLEEIRGILP------NKDSSL 364
              ...|..:....:||.||.|.|..||...|:.|||||:.|..|.:|:.|::|      :||
Mouse   322 --LSTQETIGTFPELLLAGVDTTSNTLTWALYHLSKSPEIQEALHKEVTGVVPFGKVPQHKD--- 381

  Fly   365 TIENMRNLPYLRACIKEGIRMYPIGPGTLRRMPH-DVVLSGYRVVAGTDVGIAANYQMANMEQFV 428
                ..::|.|:|.|||.:|:||:.|...|.:.. :..::|:.....|.. :..:|.::......
Mouse   382 ----FAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGFLFPKNTQF-VLCHYVVSRDPSVF 441

  Fly   429 PKVREFIPERWLR--DESNSHLVGETATPFMYLPFGFGPRSCAGKRIVDMMLEIAISRLVRNFKI 491
            |:...|.|.||||  :..|..::    .||..:|||:|.|||.|:||.::.:::.:||||:.::|
Mouse   442 PEPNSFQPHRWLRKKEADNPGIL----HPFGSVPFGYGVRSCLGRRIAELEMQLMLSRLVQKYEI 502

  Fly   492 GFDYPIENAFK--AQFFVQPNIPFKFKFIER 520
            .. .|.....|  ::..:.|:...:..|::|
Mouse   503 AL-APGMGEVKTVSRIVLVPSKKVRLHFLQR 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	133/484 (27%)
Cyp27a1	NP_077226.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..60		2/25 (8%)
		p450	82..527	CDD:278495	134/484 (28%)
		Sterol-binding. /evidence=ECO:0000255	386..400		7/13 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3255
eggNOG	1	0.900	-	-		E2759_KOG0159
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3800
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48087
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8705
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X156
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.870