DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6345 and Cdk5rap1

DIOPT Version :9

Sequence 1:	NP_650002.1	Gene:	CG6345 / 41271	FlyBaseID:	FBgn0037816	Length:	583	Species:	Drosophila melanogaster
Sequence 2:	NP_663773.1	Gene:	Cdk5rap1 / 252827	RGDID:	708387	Length:	586	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	299/538 - (55%)
Similarity:	386/538 - (71%)	Gaps:	2/538 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TSSAAGQLKSEPAARATFLERIQRGPGFQDFFAVKPASRLKTDEEEHVDTSVPYLNSIDFNGNGR 92
            ||....:.||....:..|..|:..||.||.|.......:.|....| |:...|||:..:..|..|
  Rat    34 TSCPDPEGKSSEGVQKDFSSRLATGPTFQHFLRSASVPQEKPSSPE-VEDPPPYLSGDELLGRQR 97

  Fly    93 KVHFEVYGCQMNTNDTEVVFSILKENGYLRCQEPEEADVIMLVTCAVRDGAEQRIRNRLKHLRAM 157
            ||:.|.||||||.||||:.:|||:::||||....:|||||:||||::|:.|||.|.|||..|:.:
  Rat    98 KVYLETYGCQMNVNDTEIAWSILQKSGYLRTSNLQEADVILLVTCSIREKAEQTIWNRLHQLKVL 162

  Fly   158 KNKRSTRRHPLQLTLLGCMAERLKEKLLEQEQCVDVIAGPDSYKDLPRLLAISRHYGNSAINVLL 222
            |.||...|.||::.:|||||||||.::|.:|:.||::||||:|:|||||||:... |..|.||||
  Rat   163 KAKRPRSRVPLRIGILGCMAERLKGEILNREKMVDLLAGPDAYRDLPRLLAVVES-GQQAANVLL 226

  Fly   223 SLDETYADVMPVRLNSESPTAFVSIMRGCDNMCTYCIVPFTRGRERSRPLASIVAEVKALAEQGV 287
            ||||||||:|||:.:..:.:|||||||||||||:|||||||||||||||:|||:.||:.|:|||:
  Rat   227 SLDETYADIMPVQTSPSATSAFVSIMRGCDNMCSYCIVPFTRGRERSRPVASILDEVRKLSEQGL 291

  Fly   288 KEVTLLGQNVNSYRDRTAQEEQDSLKATPVPGFSTVYKPKTGGTPFAALLRSVAQAVPDMRIRFT 352
            ||||||||||||:||.:..:...:..|....||:|.||||.||..|:.||..|::..|:||||||
  Rat   292 KEVTLLGQNVNSFRDNSEVQFSSTGSANLSRGFTTNYKPKQGGLRFSHLLDQVSRIDPEMRIRFT 356

  Fly   353 SPHPKDFSDEVLEVIRDHPNVCKQLHLPAQSGNTQVLERMRRGYSREAYLELVQHIRQFLPNVGL 417
            |||||||.||||::||:..|:|||:|||||||:::|||.||||||||||:.||.|||:.:|.|||
  Rat   357 SPHPKDFPDEVLQLIRERHNICKQIHLPAQSGSSRVLEAMRRGYSREAYVALVHHIREAIPGVGL 421

  Fly   418 SSDFICGFCGETEEEFQDTVSLIQQVQYNVAYLFAYSMREKTTAHRRYKDDVPINVKNERLQRMV 482
            |||||.|||||||::...||||:::||||..:|||||||:||.|:.|.|||||..||..||:.::
  Rat   422 SSDFITGFCGETEDDHLQTVSLLREVQYNTGFLFAYSMRQKTRAYHRLKDDVPEEVKLRRLEELI 486

  Fly   483 QVFREGATQLHRKMEGQEQLILIEGKSKRSDAHWFGRNDANIKVIVPSIYVPISGDSTARKSFGV 547
            .||||.|::::....|..||:|:||.||||.....||||||:|||.|...|....|...:.....
  Rat   487 TVFREEASKVNATSVGCTQLVLVEGFSKRSTTDLCGRNDANLKVIFPDAEVEDITDPGLKVRAQP 551

  Fly   548 GDFLAVRIEESNSQVLKG 565
            ||::.|:|..::||.|||
  Rat   552 GDYVLVKIISASSQTLKG 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6345	NP_650002.1	PRK14329	88..570	CDD:237676	282/478 (59%)
		UPF0004	93..196	CDD:279287	57/102 (56%)
		TRAM	494..568	CDD:280171	31/72 (43%)
Cdk5rap1	NP_663773.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..90		6/22 (27%)
Cdk5rap1	NP_663773.1	PRK14329	85..571	CDD:237676	285/486 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1727
eggNOG	1	0.900	-	-		E1_COG0621
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9502
Inparanoid	1	1.050	580	1.000	Inparanoid score	I988
OMA	1	1.010	-	-		QHG54971
OrthoDB	1	1.010	-	-		D407532at33208
OrthoFinder	1	1.000	-	-		FOG0005052
OrthoInspector	1	1.000	-	-		oto96331
orthoMCL	1	0.900	-	-		OOG6_102063
Panther	1	1.100	-	-	LDO	PTHR43020
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3577
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840