DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rrp46 and Exosc5

DIOPT Version :9

Sequence 1:	NP_650001.2	Gene:	Rrp46 / 41270	FlyBaseID:	FBgn0037815	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_001100963.2	Gene:	Exosc5 / 308441	RGDID:	1307861	Length:	235	Species:	Rattus norvegicus

Alignment Length:	208	Identity:	81/208 - (38%)
Similarity:	114/208 - (54%)	Gaps:	0/208 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LRQMHCEFNPLSRCDGSVMYSQGATGLIGAVLGPIEVKTQNLSIDGSYLECNYRPKAGLPQVTDR 78
            ||...||.|.|||.|||..:.||.|.::..|.||.|||......:.:.||...|||.|||.|.::
  Rat    28 LRHFACEQNLLSRPDGSASFLQGDTSVLAGVYGPAEVKVSKEIFNKATLEVILRPKIGLPGVAEK 92

  Fly    79 IREAAIRDVLELALLSEAHPRSKMSVQIQELEDRGSIDACAVNCACLAMLIGGLPLKYSFAAVHA 143
            .||..||:..|..:|...|||:.::|.:|.:.|.||:.||.:|.||:|::..|:|::..|..|..
  Rat    93 SRERLIRNTCEAVVLGALHPRTSITVVLQVVSDTGSLLACCLNAACMALVDAGVPMRALFCGVTC 157

  Fly   144 IINEQGEYVLDPDQSETLHQRASFTFAFDSVEGNLLLIQTKGSFKIAQFNDIECLCLAASAEIFQ 208
            .::..|..||||...:....||..|||.||.|..||:..|||.:..|:.........|||..||:
  Rat   158 ALDPDGNLVLDPTTKQEKEARAILTFALDSAEQKLLMSATKGLYSDAELQQCLAAAQAASQHIFR 222

  Fly   209 FYRNQVAKYHGRS 221
            |||..:.:.:.:|
  Rat   223 FYRESLQRRYSKS 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rrp46	NP_650001.2	Rph	10..215	CDD:223761	80/200 (40%)
Rrp46	NP_650001.2	RNase_PH_RRP46	14..211	CDD:206777	78/196 (40%)
Exosc5	NP_001100963.2	ECX1	10..232	CDD:131120	80/203 (39%)
Exosc5	NP_001100963.2	RNase_PH_RRP46	28..225	CDD:206777	78/196 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345937
Domainoid	1	1.000	99	1.000	Domainoid score	I6878
eggNOG	1	0.900	-	-		E1_COG0689
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5981
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4275
OMA	1	1.010	-	-		QHG53663
OrthoDB	1	1.010	-	-		D1129417at2759
OrthoFinder	1	1.000	-	-		FOG0004463
OrthoInspector	1	1.000	-	-		oto95516
orthoMCL	1	0.900	-	-		OOG6_103234
Panther	1	1.100	-	-	LDO	PTHR11953
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770