DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and ACO2

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_012335.1	Gene:	ACO2 / 853230	SGDID:	S000003736	Length:	789	Species:	Saccharomyces cerevisiae

Alignment Length:	931	Identity:	242/931 - (25%)
Similarity:	370/931 - (39%)	Gaps:	199/931 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ANPFAQFEKTFSQAGTTYKYFDLASIDSKYDQLPYSIRVLLESAV---RNCD-NFHILEKDVQSI 64
            ||.|....|.|......|... |.::| |..|:..:..:.|...:   ..|| ...|...|:.:|
Yeast    18 ANMFPSVSKNFQTKVPPYAKL-LTNLD-KIKQITNNAPLTLAEKILYSHLCDPEESITSSDLSTI 80

  Fly    65 LGWSPALKQGSNDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVID 129
            .|          :..:...|.||.:||.:...|::.|       :..|.:...:    ||.:..|
Yeast    81 RG----------NKYLKLNPDRVAMQDASAQMALLQF-------MTTGLNQTSV----PASIHCD 124

  Fly   130 HSVQVDFARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVF 194
            |.:.     ..|...|:.......|:|.|.||:..||.: .:....|||||:||        :|.
Yeast   125 HLIV-----GKDGETKDLPSSIATNQEVFDFLESCAKRY-GIQFWGPGSGIIHQ--------IVL 175

  Fly   195 ENDATDGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGK 259
            ||.:..|..:|      ||||||....|||.:..||||.:|...:.|....:..|:::|.||.||
Yeast   176 ENFSAPGLMML------GTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGK 234

  Fly   260 LSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDEN 324
            |:...|..|::..:...|...|..|..||::|.||:.||....|||.||..|.|||...||..|.
Yeast   235 LNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTSTFPYQEA 299

  Fly   325 TLGYMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRV 389
            ...|::.|||:|     :.:.........|:..|.:|.::.:.|.:|||.:...|:||..|.
Yeast   300 HKRYLQATNRAE-----VAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGPFTPD--- 356

  Fly   390 SVSDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPS 454
                        ||:|:            |.:.|....:....|:..|     .|.||||:|...
Yeast   357 ------------LSTPI------------SQYAEKSLKENWPQKVSAG-----LIGSCTNSSYQD 392

  Fly   455 VMLGAGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGN 519
            :.....|: |:|.:.||.  |.|...::|||..:...|:..|:|...::.|..::...|..|||.
Yeast   393 MSRVVDLV-KQASKAGLK--PRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQ 454

  Fly   520 SGPLEENVVNTIEKNGLVCAGVLSGNRNFEGRIHPNTRA-NYLASPLLVIAYAIAGRVDIDFEKE 583
            ..  .|:|..|.::...:   ..|.||||..|...|... |:|.||.:|.|.:.:|    |.:..
Yeast   455 WN--REDVSKTSKETNTI---FTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSG----DAQFN 510

  Fly   584 PLGVDA----NGKNVFLQDIWPTRSEIQEVENKH--------VIPAMFQEVYSKIELGSQDWQTL 636
            || .|:    |||:...|.  |...|:.:...:|        :.|.....|..|::..|...|.|
Yeast   511 PL-TDSIKLPNGKDFKFQP--PKGDELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLL 572

  Fly   637 QVSEGKLFSWSADSTYIKRPPFFEGMTRDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSP 701
            :                   ||.....::|       |...||.:....||||||.||...:...
Yeast   573 E-------------------PFKPWNGKEL-------KTNVLLKVEGKCTTDHISAAGVWLKYKG 611

  Fly   702 AARFLSERNITPRDFNSYGSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAA 766
            ....:|...:........|.                  |||..:..|         .|.||....
Yeast   612 HLENISYNTLIGAQNKETGE------------------VNKAYDLDG---------TEYDIPGLM 649

  Fly   767 ERYREEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFL-- 829
            .:::.:|.|..::...:||.||:|:.||..|..||.:.::.:|:.|||.:||...|::||.|.
Yeast   650 MKWKSDGRPWTVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANE 714

  Fly   830 -------PGQSAETLNL---------TGREV-YNIALPESGLKPGQKIQVEADGTVFETILRFDT 877
                   .|...|||||         .|.|: ..|..|.     |:...::|..|:        :
Yeast   715 SDYDKISSGDVLETLNLVDMIAKDGNNGGEIDVKITKPN-----GESFTIKAKHTM--------S 766

  Fly   878 EVDITYYKNGGILNYM--IRK 896
            :..|.::|.|..:||:  ||:
Yeast   767 KDQIDFFKAGSAINYIGNIRR 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	242/931 (26%)
		AcnA_IRP	86..576	CDD:153136	142/490 (29%)
		AcnA_IRP_Swivel	680..849	CDD:238812	48/187 (26%)
ACO2	NP_012335.1	aconitase_mito	35..782	CDD:273561	234/907 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344200
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61122
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X803
TreeFam	0	0.000	Not matched by this tool.
	5	4.750