Protein Alignment Irp-1B and ACO2

DIOPT Version :10

• Sequence 1: NP_524303.2
• Gene: Irp-1B / 41269
• FlyBaseID: FBgn0024957
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_012335.1
• Gene: ACO2 / 853230
• SGDID: S000003736
• Length: 789
• Species: Saccharomyces cerevisiae
• Alignment Length: 931
• Identity: 242/931 - (25%)
• Similarity: 370/931 - (39%)
• Gaps: 199/931 - (21%)

  Fly     4 ANPFAQFEKTFSQAGTTYKYFDLASIDSKYDQLPYSIRVLLESAV---RNCD-NFHILEKDVQSI 64
            ||.|....|.|......|... |.::| |..|:..:..:.|...:   ..|| ...|...|:.:|
Yeast    18 ANMFPSVSKNFQTKVPPYAKL-LTNLD-KIKQITNNAPLTLAEKILYSHLCDPEESITSSDLSTI 80

  Fly    65 LGWSPALKQGSNDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVID 129
            .|          :..:...|.||.:||.:...|::.|       :..|.:...:    ||.:..|
Yeast    81 RG----------NKYLKLNPDRVAMQDASAQMALLQF-------MTTGLNQTSV----PASIHCD 124

  Fly   130 HSVQVDFARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVF 194
            |.:.     ..|...|:.......|:|.|.||:..||.: .:....|||||:||        :|.
Yeast   125 HLIV-----GKDGETKDLPSSIATNQEVFDFLESCAKRY-GIQFWGPGSGIIHQ--------IVL 175

  Fly   195 ENDATDGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGK 259
            ||.:..|..:|      ||||||....|||.:..||||.:|...:.|....:..|:::|.||.||
Yeast   176 ENFSAPGLMML------GTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGK 234

  Fly   260 LSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDEN 324
            |:...|..|::..:...|...|..|..||::|.||:.||....|||.||..|.|||...||..|.
Yeast   235 LNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTSTFPYQEA 299

  Fly   325 TLGYMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRV 389
            ...|::.|||:|     :.:.........|:..|.:|.::.:.|.:|||.:...|:||..|.
Yeast   300 HKRYLQATNRAE-----VAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGPFTPD--- 356

  Fly   390 SVSDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPS 454
                        ||:|:            |.:.|....:....|:..|     .|.||||:|...
Yeast   357 ------------LSTPI------------SQYAEKSLKENWPQKVSAG-----LIGSCTNSSYQD 392

  Fly   455 VMLGAGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGN 519
            :.....|: |:|.:.||.  |.|...::|||..:...|:..|:|...::.|..::...|..|||.
Yeast   393 MSRVVDLV-KQASKAGLK--PRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQ 454

  Fly   520 SGPLEENVVNTIEKNGLVCAGVLSGNRNFEGRIHPNTRA-NYLASPLLVIAYAIAGRVDIDFEKE 583
            ..  .|:|..|.::...:   ..|.||||..|...|... |:|.||.:|.|.:.:|    |.:..
Yeast   455 WN--REDVSKTSKETNTI---FTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSG----DAQFN 510

  Fly   584 PLGVDA----NGKNVFLQDIWPTRSEIQEVENKH--------VIPAMFQEVYSKIELGSQDWQTL 636
            || .|:    |||:...|.  |...|:.:...:|        :.|.....|..|::..|...|.|
Yeast   511 PL-TDSIKLPNGKDFKFQP--PKGDELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLL 572

  Fly   637 QVSEGKLFSWSADSTYIKRPPFFEGMTRDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSP 701
            :                   ||.....::|       |...||.:....||||||.||...:...
Yeast   573 E-------------------PFKPWNGKEL-------KTNVLLKVEGKCTTDHISAAGVWLKYKG 611

  Fly   702 AARFLSERNITPRDFNSYGSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAA 766
            ....:|...:........|.                  |||..:..|         .|.||....
Yeast   612 HLENISYNTLIGAQNKETGE------------------VNKAYDLDG---------TEYDIPGLM 649

  Fly   767 ERYREEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFL-- 829
            .:::.:|.|..::...:||.||:|:.||..|..||.:.::.:|:.|||.:||...|::||.|.
Yeast   650 MKWKSDGRPWTVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANE 714

  Fly   830 -------PGQSAETLNL---------TGREV-YNIALPESGLKPGQKIQVEADGTVFETILRFDT 877
                   .|...|||||         .|.|: ..|..|.     |:...::|..|:        :
Yeast   715 SDYDKISSGDVLETLNLVDMIAKDGNNGGEIDVKITKPN-----GESFTIKAKHTM--------S 766

  Fly   878 EVDITYYKNGGILNYM--IRK 896
            :..|.::|.|..:||:  ||:
Yeast   767 KDQIDFFKAGSAINYIGNIRR 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	242/931 (26%)
ACO2	NP_012335.1	aconitase_mito	35..782	CDD:273561	234/907 (26%)