Protein Alignment Irp-1B and LEU1

DIOPT Version :10

• Sequence 1: NP_524303.2
• Gene: Irp-1B / 41269
• FlyBaseID: FBgn0024957
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_011506.1
• Gene: LEU1 / 852875
• SGDID: S000002977
• Length: 779
• Species: Saccharomyces cerevisiae
• Alignment Length: 810
• Identity: 195/810 - (24%)
• Similarity: 318/810 - (39%)
• Gaps: 183/810 - (22%)

  Fly   128 IDHSVQVD----------FARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVH 182
            :||::..:          |.:..|:..:.::|  |.|.::|     |...|.   :.....||||
Yeast    68 VDHNIPTESRKNFKSLDTFIKQTDSRLQVKTL--ENNVKQF-----GVPYFG---MSDARQGIVH 122

  Fly   183 QVNLEYLARVVFENDATDGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISML 247
            .:..|       |.....|:      :||..||||:.....|.|.:|:|..|.|.|:..|:|...
Yeast   123 TIGPE-------EGFTLPGT------TVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTIIQA 174

  Fly   248 LPEVIGYKLEGKLSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEY 312
            ..:.:...:.|||||.:||.||:|.|...:...|..|..:||.|..:..||:..|.::.||..|.
Yeast   175 KSKNMRITVNGKLSPGITSKDLILYIIGLIGTAGGTGCVIEFAGEAIEALSMEARMSMCNMAIEA 239

  Fly   313 GATVGYFPIDENTLGYMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVT 377
            ||..|....||.|..|.|....:.|.    .::.||....:. ....:..||...|.::...|:.
Yeast   240 GARAGMIKPDETTFQYTKGRPLAPKG----AEWEKAVAYWKT-LKTDEGAKFDHEINIEAVDVIP 299

  Fly   378 SVSGPKRPHDRVSVSDMPEDFKSCLSSPVGFKGF--AIA---PEAQSAFGEFQWDDGKTYKLHHG 437
            :::....|.|.:.::....|.|: ::.|:...|.  |:|   .|..:.....:.|  |.:
Yeast   300 TITWGTSPQDALPITGSVPDPKN-VTDPIKKSGMERALAYMGLEPNTPLKSIKVD--KVF----- 356

  Fly   438 SVVIAAITSCTNTSNPSVMLGAGLLAKKAVEKGLSILPYIKTSL-SPGSGVVTYYLKESGVIPYL 501
                  |.||||.....:...|      ||.:|..:...||.:: .||||:|....:..|:....
Yeast   357 ------IGSCTNGRIEDLRSAA------AVVRGQKLASNIKLAMVVPGSGLVKKQAEAEGLDKIF 409

  Fly   502 EKLGFDIVGYGCMTCIGNSGPLEENVVNTIEKNGLVCAGVLSGNRNFEGRIHPNTRANYLASPLL 566
            ::.||:....||..|:|    :..::::..|:    ||.  :.|||||||....:| .:|.||.:
Yeast   410 QEAGFEWREAGCSICLG----MNPDILDAYER----CAS--TSNRNFEGRQGALSR-THLMSPAM 463

  Fly   567 VIAYAIAGR-VDI-DFEKEPLGVDANGKNVFLQDIWPTRSEIQEVENKHVIPAMFQEVYSKIELG 629
            ..|..|||. ||| :||.:.....:....|..:|    ..|::.....|..|...::  :..::.
Yeast   464 AAAAGIAGHFVDIREFEYKDQDQSSPKVEVTSED----EKELESAAYDHAEPVQPED--APQDIA 522

  Fly   630 SQDWQTLQVSEGKLFSWSADSTYIK-----RPPF--FEGMTRDLPKLQSIQKARCLLFLGDSVTT 687
            :.:.:.:.|        .:|.|..|     ..||  .||::..|.|.              :|.|
Yeast   523 NDELKDIPV--------KSDDTPAKPSSSGMKPFLTLEGISAPLDKA--------------NVDT 565

  Fly   688 DHISPAGSIARTSPAARFLSERNITPRDFNSYGSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTV 752
            |                     .|.|:.|.....|.|    :.:|.|...|.          |..
Yeast   566 D---------------------AIIPKQFLKTIKRTG----LKKGLFYEWRF----------RKD 595

  Fly   753 HIPSQEELDIFDAAERYREEGTPLVLVVGKDYGSGSSRD---WAAKGPFLLGVKAVIAESYERIH 814
            .....:|.|.....|.:||  ..:::|.|.::|.||||:   ||.|.   .|:|::||.||..|.
Yeast   596 DQGKDQETDFVLNVEPWRE--AEILVVTGDNFGCGSSREHAPWALKD---FGIKSIIAPSYGDIF 655

  Fly   815 RSNLVGMGIIPL----QFLPGQSAETLNLTGREVYNIALPESGLKPGQKIQVEADGTVFETILRF 875
            .:|....|::|:    |.:..:.....|..|:...::        |.||| :::||.|.  :..|
Yeast   656 YNNSFKNGLLPIRLDQQIIIDKLIPIANKGGKLCVDL--------PNQKI-LDSDGNVL--VDHF 709

  Fly   876 DTE-------------VDITYYKNGGILNY 892
            :.|             :.||..|...|..|
Yeast   710 EIEPFRKHCLVNGLDDIGITLQKEEYISRY 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	195/810 (24%)
LEU1	NP_011506.1	PRK05478	9..480	CDD:235490	124/470 (26%)
		leuD	545..736	CDD:129275	58/255 (23%)