DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and LYS4

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_010520.3	Gene:	LYS4 / 851820	SGDID:	S000002642	Length:	693	Species:	Saccharomyces cerevisiae

Alignment Length:	835	Identity:	193/835 - (23%)
Similarity:	329/835 - (39%)	Gaps:	219/835 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 HILEKDVQSILGWSPALKQG----SNDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDP 115
            ::.||.|||   ::..|.:|    |.|. ||.|||..:..| ...|..:.|       :.||...
Yeast    22 NLTEKIVQS---YAVNLPEGKVVHSGDY-VSIKPAHCMSHD-NSWPVALKF-------MGLGATK 74

  Fly   116 EKINPICPADLV--IDHSVQVDFARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGS 178
            .|    .|:.:|  :||.:|            |:|   |:|..::..::..||. :::...|.|.
Yeast    75 IK----NPSQIVTTLDHDIQ------------NKS---EKNLTKYKNIENFAKK-HHIDHYPAGR 119

  Fly   179 GIVHQVNLEYLARVVFENDATDGSKILYP-DSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQ 242
            ||.||:.:|            :|  ..:| :..|.:|||:....|||.||..:...:|.|:....
Yeast   120 GIGHQIMIE------------EG--YAFPLNMTVASDSHSNTYGGLGSLGTPIVRTDAAAIWATG 170

  Fly   243 SISMLLPEVIGYKLEGKLSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISN 307
            .....:|.|...:|:|:|...|:..|:::.:........|:...:||.|..:..|.|..|.||:|
Yeast   171 QTWWQIPPVAQVELKGQLPQGVSGKDIIVALCGLFNNDQVLNHAIEFTGDSLNALPIDHRLTIAN 235

  Fly   308 MCPEYGATVGYFPIDENTLGYMKQTNRSEK-------KIDIIRQYLKATQQLRNYADAAQDPKFT 365
            |..|:||..|.||:|:..:.:.|  ||.:|       :|:  .:.::|.::......|.:|..:.
Yeast   236 MTTEWGALSGLFPVDKTLIDWYK--NRLQKLGTNNHPRIN--PKTIRALEEKAKIPKADKDAHYA 296

  Fly   366 QSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGK 430
            :.:.:||:|:...||||    :.|.||:..:|...                          .|.|
Yeast   297 KKLIIDLATLTHYVSGP----NSVKVSNTVQDLSQ--------------------------QDIK 331

  Fly   431 TYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKA-VEKGLSILPYIKTSLSPGSGVVTYYLKE 494
            ..|        |.:.||||:....:...|.::.... :.|...:.|.::..::..|..:....::
Yeast   332 INK--------AYLVSCTNSRLSDLQSAADVVCPTGDLNKVNKVAPGVEFYVAAASSEIEADARK 388

  Fly   495 SGVIPYLEKLGFDIVGYGCMTCIG-NSGPLEENVVNTIEKNGLVCAGVLSGNRNFEGRIHPNTRA 558
            ||....|.|.|...:..||..||| .:|.||...|           |:.:.||||:||:......
Yeast   389 SGAWEKLLKAGCIPLPSGCGPCIGLGAGLLEPGEV-----------GISATNRNFKGRMGSKDAL 442

  Fly   559 NYLASPLLVIAYAIAGRVDIDFEKEPLGVDANGKNVFLQDIWPTRSEIQEVENKHVIPAMFQEVY 623
            .|||||.:|.|.|:.|::     ..|..|.:..:..|.    ..::||  :||    |.:.:||.
Yeast   443 AYLASPAVVAASAVLGKI-----SSPAEVLSTSEIPFS----GVKTEI--IEN----PVVEEEVN 492

  Fly   624 SKIELGSQDWQTLQVSEGKLFSWSADSTYIKRPPFFEGMTRDLPKLQSIQKARCLLFLGDSVTTD 688
            ::.|...|..:.|                       ||..|:.       ....:|...|::.||
Yeast   493 AQTEAPKQSVEIL-----------------------EGFPREF-------SGELVLCDADNINTD 527

  Fly   689 HISPAGSIARTSPAARFLSERNITPRDFNSYGSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTVH 753
            .|.|          .::..:.:: |::                 ..|.:.:.|
Yeast   528 GIYP----------GKYTYQDDV-PKE-----------------KMAQVCMEN------------ 552

  Fly   754 IPSQEELDIFDAAERYREEGTPLVLVV-GKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSN 817
                     :||  .:|.:..|..:|| |.::|:||||:.||......|:..|::.|:..|...|
Yeast   553 ---------YDA--EFRTKVHPGDIVVSGFNFGTGSSREQAATALLAKGINLVVSGSFGNIFSRN 606

  Fly   818 LVGMGIIPLQFLPGQSAETLNLTGREVYNIALPESGLKPGQKIQVE-ADGTVFET 871
            .:...::.|: :|....:.     ||.|..|..|...:.|..::.: ||..|..|
Yeast   607 SINNALLTLE-IPALIKKL-----REKYQGAPKELTRRTGWFLKWDVADAKVVVT 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	193/835 (23%)
		AcnA_IRP	86..576	CDD:153136	123/501 (25%)
		AcnA_IRP_Swivel	680..849	CDD:238812	32/169 (19%)
LYS4	NP_010520.3	h_aconitase	20..693	CDD:129245	193/835 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810