Protein Alignment Irp-1B and ACO1

DIOPT Version :10

• Sequence 1: NP_524303.2
• Gene: Irp-1B / 41269
• FlyBaseID: FBgn0024957
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_013407.1
• Gene: ACO1 / 851013
• SGDID: S000004295
• Length: 778
• Species: Saccharomyces cerevisiae
• Alignment Length: 911
• Identity: 252/911 - (27%)
• Similarity: 385/911 - (42%)
• Gaps: 214/911 - (23%)

  Fly    30 DSKYDQLPYSIRVLLE-----SAVRNCDNFHILEKDVQSILGWSPALKQG------SNDVE--VS 81
            |||.:|      .|||     :..:|.:...|:.|.:.....::..:..|      ..|::  ||
Yeast    25 DSKVNQ------NLLEDHSFINYKQNVETLDIVRKRLNRPFTYAEKILYGHLDDPHGQDIQRGVS 83

  Fly    82 F---KPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPI---CPADLVIDHSVQV------ 134
            :   :|.||..||.|...|::.|.:        .|.|:...|:   |      ||.:|.
Yeast    84 YLKLRPDRVACQDATAQMAILQFMS--------AGLPQVAKPVTVHC------DHLIQAQVGGEK 134

  Fly   135 DFARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDAT 199
            |..||.|.           |||.:.||. .|.|..||....|||||:||        :|.||.|.
Yeast   135 DLKRAIDL-----------NKEVYDFLA-SATAKYNMGFWKPGSGIIHQ--------IVLENYAF 179

  Fly   200 DGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLV 264
            .|:.|      :||||||....|||.|..||||.:|..||.|:...:..|:::|.||.||::...
Yeast   180 PGALI------IGTDSHTPNAGGLGQLAIGVGGADAVDVMAGRPWELKAPKILGVKLTGKMNGWT 238

  Fly   265 TSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYM 329
            :..|::|.:.......|..||.||::|.||...|.....||.||..|.|||...||.:::.:.|:
Yeast   239 SPKDIILKLAGITTVKGGTGKIVEYFGDGVDTFSATGMGTICNMGAEIGATTSVFPFNKSMIEYL 303

  Fly   330 KQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRVSVSDM 394
            :.|.|. |..|..:.|.|      :...|.:|.::.:.:.:||:|:...::||..|.....||.|
Yeast   304 EATGRG-KIADFAKLYHK------DLLSADKDAEYDEVVEIDLNTLEPYINGPFTPDLATPVSKM 361

  Fly   395 PEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGA 459
            .|              .|:|               ..:.|   .|.:..|.||||:|...:...|
Yeast   362 KE--------------VAVA---------------NNWPL---DVRVGLIGSCTNSSYEDMSRSA 394

  Fly   460 GLLAKKAVEKGLSILPYIKT--SLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIG--NS 520
            .:: |.|...||.    .||  :::|||..:...::..|.:...::.|..::...|..|||  :.
Yeast   395 SIV-KDAAAHGLK----SKTIFTVTPGSEQIRATIERDGQLETFKEFGGIVLANACGPCIGQWDR 454

  Fly   521 GPLEENVVNTIEKNGLVCAGVLSGNRNFEGRI--HPNTRANYLASPLLVIAYAIAGRVDIDFEKE 583
            ..:::...|||         |.|.||||..|.  :|.|.| ::|||.||.|:||||    |....
Yeast   455 RDIKKGDKNTI---------VSSYNRNFTSRNDGNPQTHA-FVASPELVTAFAIAG----DLRFN 505

  Fly   584 PLG---VDANGKNVFLQ----DIWPTRSEIQEVENKHVIPAMFQEVYSKIELGSQDWQTLQVSEG 641
            ||.   .|.:|....|:    |..|.|. ....||.:..|             ..|..|::|.
Yeast   506 PLTDKLKDKDGNEFMLKPPHGDGLPQRG-YDAGENTYQAP-------------PADRSTVEVK-- 554

  Fly   642 KLFSWSADSTYIKRP--PFFEGMTRDLPKL-QSIQKARCLLFLGDSVTTDHISPAGSIARTSPAA 703
              .|.::|...:.:|  |:.....:|:|.| :::.|          .||||||.||.
Yeast   555 --VSPTSDRLQLLKPFKPWDGKDAKDMPILIKAVGK----------TTTDHISMAGP-------- 599

  Fly   704 RFLSERNITPRDFNSY--GSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAA 766
             :|..|.......|:|  |      ||.:....||.             ..::.:.|...:.|.|
Yeast   600 -WLKYRGHLENISNNYMIG------AINAENKKANC-------------VKNVYTGEYKGVPDTA 644

  Fly   767 ERYREEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPG 831
            ..||::|...|::..:::|.||||:.||..|..||..|:|.:|:.|||.:||...|::||.|...
Yeast   645 RDYRDQGIKWVVIGDENFGEGSSREHAALEPRFLGGFAIITKSFARIHETNLKKQGLLPLNFKNP 709

  Fly   832 QSAETLNLTGR-EVYNIALPESGLKPGQKIQVEA---DGTVFETIL--RFDTEVDITYYKNGGIL 890
            ...:.:|...| ::..:|    .|.||:.:.:..   :|..::.:|  .|:.| .|.::|.|..|
Yeast   710 ADYDKINPDDRIDILGLA----ELAPGKPVTMRVHPKNGKPWDAVLTHTFNDE-QIEWFKYGSAL 769

  Fly   891 N 891
            |
Yeast   770 N 770

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	252/911 (28%)
ACO1	NP_013407.1	aconitase_mito	41..772	CDD:273561	245/889 (28%)