DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and ACO2

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_567763.2	Gene:	ACO2 / 828805	AraportID:	AT4G26970	Length:	995	Species:	Arabidopsis thaliana

Alignment Length:	881	Identity:	527/881 - (59%)
Similarity:	664/881 - (75%)	Gaps:	14/881 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KYFDLASI-DSKYDQLPYSIRVLLESAVRNCDNFHILEKDVQSILGWSPALKQGSNDVEVSFKPA 85
            ||:.|.:: |.:.|:||:|:|:|||||:|||||:.:.:.||:.||.|.   ...:..||::||||
plant   121 KYYSLPALNDPRIDKLPFSVRILLESAIRNCDNYQVTKDDVEKILDWE---NTSTKQVEIAFKPA 182

  Fly    86 RVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQVDFARAPDALAKNQSLE 150
            |||||||||||.:||.|:|||||.:||.||.||||:.|.|||:|||:||||||:.||..||..||
plant   183 RVILQDFTGVPVLVDLASMRDAVKNLGSDPSKINPLVPVDLVVDHSIQVDFARSEDAAQKNLELE 247

  Fly   151 FERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYPDSVVGTDS 215
            |:||||||||||||:.||.|||:||||||||||||||||.||||.:..     .|||||||||||
plant   248 FKRNKERFTFLKWGSTAFQNMLVVPPGSGIVHQVNLEYLGRVVFNSKG-----FLYPDSVVGTDS 307

  Fly   216 HTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLTITKHLRQL 280
            |||||:||||.|||||||||||.||||.:||:||.|:|:||:|||...||:||||||:|:.||:.
plant   308 HTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLDGKLKEGVTATDLVLTVTQILRKH 372

  Fly   281 GVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNRSEKKIDIIRQY 345
            |||||||||||.|::|||:||||||:||.||||||:|:||:|..||.|:|.|.||::.:.:|..|
plant   373 GVVGKFVEFYGEGMSELSLADRATIANMSPEYGATMGFFPVDHVTLEYLKLTGRSDETVSMIESY 437

  Fly   346 LKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCLSSPVGFKG 410
            |:|.....:|.:..|:..:|..:.|||..|...:||||||||||.:.||..|:.:||.:||||||
plant   438 LRANNMFVDYNEPQQERAYTSYLQLDLGHVEPCISGPKRPHDRVPLKDMKADWHACLDNPVGFKG 502

  Fly   411 FAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEKGLSILP 475
            ||:..|.|....:|.: :|:..::.|||||||||||||||||||||:||.|:||||.:.||.:.|
plant   503 FAVPKEKQEEVVKFSY-NGQPAEIKHGSVVIAAITSCTNTSNPSVMIGAALVAKKASDLGLKVKP 566

  Fly   476 YIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIEKNGLVCAG 540
            ::||||:|||.||..||..||:...|.|.||:||||||.|||||||.|:..|.:.||...::.|.
plant   567 WVKTSLAPGSRVVEKYLDRSGLRESLTKQGFEIVGYGCTTCIGNSGNLDPEVASAIEGTDIIPAA 631

  Fly   541 VLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPLGVDANGKNVFLQDIWPTRSE 605
            |||||||||||:||.|||||||||.||:|||:||.|||||||||:|..::||:|:|:|:||:..|
plant   632 VLSGNRNFEGRVHPQTRANYLASPPLVVAYALAGTVDIDFEKEPIGTRSDGKSVYLRDVWPSNEE 696

  Fly   606 IQEVENKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWSADSTYIKRPPFFEGMTRDLPKLQ 670
            :.:|....|:|:||:..|..|..|:..|..|......|:||..:||||..||:|:.||.:.|..:
plant   697 VAQVVQYSVLPSMFKSSYETITEGNPLWNELSAPSSTLYSWDPNSTYIHEPPYFKNMTANPPGPR 761

  Fly   671 SIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRDFNSYGSRRGNDAIMSRGTFA 735
            .::.|.|||..|||||||||||||:|.:|||||:||.:|.:...||||||||||||.:|:|||||
plant   762 EVKDAYCLLNFGDSVTTDHISPAGNIQKTSPAAKFLMDRGVISEDFNSYGSRRGNDEVMARGTFA 826

  Fly   736 NIRLVNKLVE-KTGPRTVHIPSQEELDIFDAAERYREEGTPLVLVVGKDYGSGSSRDWAAKGPFL 799
            |||:||||:: :.||.|||||:.|:|.:||||.:|:......:::.|.:||||||||||||||.|
plant   827 NIRIVNKLLKGEVGPNTVHIPTGEKLSVFDAASKYKTAEQDTIILAGAEYGSGSSRDWAAKGPLL 891

  Fly   800 LGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNLTGREVYNIALPE--SGLKPGQKIQV 862
            ||||||||:|:||||||||.|||||||.|..|:.||||.|||.|.|.:.||.  |.::|||.:.|
plant   892 LGVKAVIAKSFERIHRSNLAGMGIIPLCFKAGEDAETLGLTGHERYTVHLPTKVSDIRPGQDVTV 956

  Fly   863 EAD-GTVFETILRFDTEVDITYYKNGGILNYMIRKM 897
            ..| |..|...|||||||::.||.:||||.|:||.:
plant   957 TTDSGKSFVCTLRFDTEVELAYYDHGGILPYVIRSL 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	527/881 (60%)
		AcnA_IRP	86..576	CDD:153136	314/489 (64%)
		AcnA_IRP_Swivel	680..849	CDD:238812	112/169 (66%)
ACO2	NP_567763.2	PLN00070	70..995	CDD:215047	527/881 (60%)
		AcnA_IRP	183..667	CDD:153136	314/489 (64%)
		AcnA_IRP_Swivel	771..939	CDD:238812	112/167 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	643	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1070	1.000	Inparanoid score	I33
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	1	1.000	-	-		mtm1118
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	O	PTHR11670
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840