DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and ACO3

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_178634.2	Gene:	ACO3 / 815120	AraportID:	AT2G05710	Length:	990	Species:	Arabidopsis thaliana

Alignment Length:	904	Identity:	548/904 - (60%)
Similarity:	674/904 - (74%)	Gaps:	16/904 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGANPFAQFEKTFSQ--AGTTYKYFDLASI-DSKYDQLPYSIRVLLESAVRNCDNFHILEKDVQ 62
            |:..:||.....|..:  .|...|::.|.:: |.:.|:||||||:|||||:||||||.:.::||:
plant    93 MASEHPFKGIFTTLPKPGGGEFGKFYSLPALNDPRVDKLPYSIRILLESAIRNCDNFQVTKEDVE 157

  Fly    63 SILGWSPALKQGSNDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLV 127
            .|:.|.   |.....||:.||||||:||||||||||||.|.||||:..||.|..||||:.|.|||
plant   158 KIIDWE---KTSPKQVEIPFKPARVLLQDFTGVPAVVDLACMRDAMNKLGSDSNKINPLVPVDLV 219

  Fly   128 IDHSVQVDFARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARV 192
            ||||||||.||:.:|:..|..|||:||||||.|||||:.||.|||:||||||||||||||||.||
plant   220 IDHSVQVDVARSENAVQANMELEFQRNKERFAFLKWGSTAFQNMLVVPPGSGIVHQVNLEYLGRV 284

  Fly   193 VFENDATDGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLE 257
            ||.   |.|  :||||||||||||||||:||||.|||||||||||.||||.:||:||.|:|:||.
plant   285 VFN---TKG--LLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEATMLGQPMSMVLPGVVGFKLA 344

  Fly   258 GKLSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPID 322
            ||:...||:||||||:|:.||:.|||||||||||.|::.||:||||||:||.||||||:|:||:|
plant   345 GKMRNGVTATDLVLTVTQMLRKHGVVGKFVEFYGNGMSGLSLADRATIANMSPEYGATMGFFPVD 409

  Fly   323 ENTLGYMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHD 387
            ..||.|:|.|.||::.:.:|..||:|.....:|.:..||..::..:.|:|..|...:||||||||
plant   410 HVTLQYLKLTGRSDETVAMIEAYLRANNMFVDYNEPQQDRVYSSYLELNLDDVEPCISGPKRPHD 474

  Fly   388 RVSVSDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSN 452
            ||::.:|..|:.|||.|.||||||||..|||.....|.: ||:..:|.|||||||||||||||||
plant   475 RVTLKEMKADWHSCLDSKVGFKGFAIPKEAQEKVVNFSF-DGQPAELKHGSVVIAAITSCTNTSN 538

  Fly   453 PSVMLGAGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCI 517
            |||||||||:||||.:.||.:.|:|||||:|||||||.||.:||:..||.:.||:||||||.|||
plant   539 PSVMLGAGLVAKKACDLGLQVKPWIKTSLAPGSGVVTKYLLKSGLQEYLNEQGFNIVGYGCTTCI 603

  Fly   518 GNSGPLEENVVNTIEKNGLVCAGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEK 582
            ||||.:.|:|...|.:|.:|.|.|||||||||||:||.|||||||||.||:|||:||.|:||||.
plant   604 GNSGEINESVGAAITENDIVAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTVNIDFET 668

  Fly   583 EPLGVDANGKNVFLQDIWPTRSEIQEVENKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWS 647
            ||:|...|||:|||:|||||..||.||....|:|.||:..|..|..|:..|..|.|.|..|:||.
plant   669 EPIGKGKNGKDVFLRDIWPTTEEIAEVVQSSVLPDMFRATYESITKGNPMWNKLSVPENTLYSWD 733

  Fly   648 ADSTYIKRPPFFEGMTRDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNIT 712
            .:||||..||:|:.||.|.|...:::.|.|||..|||:|||||||||:|.:.||||:||.||.:.
plant   734 PNSTYIHEPPYFKDMTMDPPGPHNVKDAYCLLNFGDSITTDHISPAGNIQKDSPAAKFLMERGVD 798

  Fly   713 PRDFNSYGSRRGNDAIMSRGTFANIRLVNKLVE-KTGPRTVHIPSQEELDIFDAAERYREEGTPL 776
            .:||||||||||||.||:||||||||:||||:. :.||:||||||.|:|.:||||.||:..|...
plant   799 RKDFNSYGSRRGNDEIMARGTFANIRIVNKLMNGEVGPKTVHIPSGEKLSVFDAAMRYKSSGEDT 863

  Fly   777 VLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNLTG 841
            :::.|.:||||||||||||||.|.|||||||:|:||||||||||||||||.|..|:.|:||.|||
plant   864 IILAGAEYGSGSSRDWAAKGPMLQGVKAVIAKSFERIHRSNLVGMGIIPLCFKSGEDADTLGLTG 928

  Fly   842 REVYNIALPE--SGLKPGQKIQVEAD-GTVFETILRFDTEVDITYYKNGGILNYMIRKM 897
            .|.|.|.||.  |.::|||.:.|..| |..|...:||||||::.|:.:||||.|:||.:
plant   929 HERYTIHLPTDISEIRPGQDVTVTTDNGKSFTCTVRFDTEVELAYFNHGGILPYVIRNL 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	548/904 (61%)
		AcnA_IRP	86..576	CDD:153136	320/489 (65%)
		AcnA_IRP_Swivel	680..849	CDD:238812	115/169 (68%)
ACO3	NP_178634.2	PLN00070	59..990	CDD:215047	548/904 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	643	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1657
Inparanoid	1	1.050	1070	1.000	Inparanoid score	I33
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	1	1.000	-	-		mtm1118
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	LDO	PTHR11670
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840