Protein Alignment Irp-1B and Aco2

DIOPT Version :10

• Sequence 1: NP_524303.2
• Gene: Irp-1B / 41269
• FlyBaseID: FBgn0024957
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_077374.2
• Gene: Aco2 / 79250
• RGDID: 621360
• Length: 780
• Species: Rattus norvegicus
• Alignment Length: 919
• Identity: 245/919 - (26%)
• Similarity: 374/919 - (40%)
• Gaps: 244/919 - (26%)

  Fly    32 KYDQLPYSIRVLLESAVRNCDNFHILEKDVQSILGWSPALKQG------SNDVE-----VSFKPA 85
            :||        |||.      |.:|:.|.:...|..|..:..|      :.::|     :..:|.
  Rat    44 RYD--------LLEK------NINIVRKRLNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPD 94

  Fly    86 RVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQV------DFARAPDALA 144
            ||.:||.|...|::.|.:        .|.|:   ...|:.:..||.::.      |..||.|.
  Rat    95 RVAMQDATAQMAMLQFIS--------SGLPK---VAVPSTIHCDHLIEAQLGGEKDLRRAKDI-- 146

  Fly   145 KNQSLEFERNKERFTFL-----KWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKI 204
                     |:|.:.||     |:|...:.      |||||:||:.||..|
  Rat   147 ---------NQEVYNFLATAGAKYGVGFWR------PGSGIIHQIILENYA-------------- 182

  Fly   205 LYPD-SVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTD 268
             ||. .::||||||....|||.:..||||.:|..||.|....:..|:|||.||.|.||...:..|
  Rat   183 -YPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGTLSGWTSPKD 246

  Fly   269 LVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTN 333
            ::|.:...|...|..|..||::||||..:|....|||.||..|.|||...||.:.....|:.:|.
  Rat   247 VILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTG 311

  Fly   334 RSEKKIDIIRQYLKATQQLRNYADAAQDP-------KFTQSITLDLSTVVTSVSGPKRPHDRVSV 391
            |::               :.|.|:..:|.       ::.|.|.::|:.:...::||..|.
  Rat   312 RAD---------------IANLAEEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTPD----- 356

  Fly   392 SDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVM 456
                      |:.||...|.....|.        |.         ..:.:..|.||||:|...:.
  Rat   357 ----------LAHPVADVGTVAEKEG--------WP---------LDIRVGLIGSCTNSSYEDMG 394

  Fly   457 LGAGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSG 521
            ..|. :||:|:..||....  :.:::|||..:...::..|....|..:|..::...|..|||.
  Rat   395 RSAA-VAKQALAHGLKCKS--QFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQ-- 454

  Fly   522 PLEENVVNTIEKNGLVCAGVLSGNRNFEGR--IHPNTRANYLASPLLVIAYAIAGRVDIDFEKEP 584
             .:...:...|||.:    |.|.||||.||  .:|.|.| ::.||.:|.|.||||.:..:.|.:.
  Rat   455 -WDRKDIKKGEKNTI----VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDF 513

  Fly   585 L-GVDANGKNVFLQDIWPTRSEIQEVENKHVIPAMFQEVY---------SKIELGSQDWQTLQVS 639
            | |.|  ||...|:     ..:..|:......|.  |:.|         .:::: |...|.||:.
  Rat   514 LTGKD--GKKFKLE-----APDADELPRSDFDPG--QDTYQHPPKDSSGQRVDV-SPTSQRLQLL 568

  Fly   640 EGKLFSWSADSTYIKRPPFFEGMTRDLPKLQSI--QKARCLLFLGDSVTTDHISPAGSIARTSPA 702
            |                ||.:...:||..||.:  .|.:|        ||||||.||...:
  Rat   569 E----------------PFDKWDGKDLEDLQILIKVKGKC--------TTDHISAAGPWLK---- 605

  Fly   703 ARFLSERNITPRDFNSYGSRRGNDAI-----MSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDI 762
                         |..:.....|:.:     :..|...::|  |.:.::.||    :|
  Rat   606 -------------FRGHLDNISNNLLIGAINIENGKANSVR--NAVTQEFGP----VP------- 644

  Fly   763 FDAAERYREEGTPLVLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQ 827
             |.|..|::.|...|::..::||.||||:.||..|..||.:|:|.:|:.|||.:||...|::||.
  Rat   645 -DTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLT 708

  Fly   828 FLPGQSAETLNLTGREVYNIALPESGLK---PGQKIQV---EADGTVFETILRFDT--EVDITYY 884
            |........::...:      |...|||   ||:.:..   ..:||. ||||...|  |..|.::
  Rat   709 FADPSDYNKIHPVDK------LTIQGLKDFAPGKPLNCIIKHPNGTQ-ETILLNHTFNETQIEWF 766

  Fly   885 KNGGILNYM 893
            :.|..||.|
  Rat   767 RAGSALNRM 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	245/919 (27%)
Aco2	NP_077374.2	aconitase_mito	45..775	CDD:273561	244/916 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	524..560		5/43 (12%)