Protein Alignment Irp-1B and Ireb2

DIOPT Version :10

• Sequence 1: NP_524303.2
• Gene: Irp-1B / 41269
• FlyBaseID: FBgn0024957
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_073146.2
• Gene: Ireb2 / 64602
• MGIID: 1928268
• Length: 963
• Species: Mus musculus
• Alignment Length: 952
• Identity: 510/952 - (53%)
• Similarity: 684/952 - (71%)
• Gaps: 87/952 - (9%)

  Fly    22 KYFDLASI-DSKYDQLPYSIRVLLESAVRNCDNFHILEKDVQSILGWSPALKQGSNDVEVSFKPA 85
            |:|::..: .:|||.||||||||||:||||||.|.:.::||.:||.|    |...::|||.|.||
Mouse    24 KFFNVPKLGGTKYDILPYSIRVLLEAAVRNCDGFLMKKEDVMNILDW----KTKQSNVEVPFFPA 84

  Fly    86 RVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQVDFARA----------- 139
            ||:||||||:||:|||||||:||..|||||:|::|.||.||.:|||:|:||::.
Mouse    85 RVVLQDFTGIPAMVDFAAMREAVKTLGGDPKKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGG 149

  Fly   140 --------------------------------------------------------------PDA 142
                                                                          |:.
Mouse   150 DLQKAGKLSPLKVQSKKLPCRGQTTCRGSCDSGELSRNSGTFSSQIENTPVLCPFHLQPVPEPET 214

  Fly   143 LAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYP 207
            :.|||.:||.||:||..|.||.:.||.|:.::|||:|:.||||||||:|||||.  ||   :|:|
Mouse   215 VLKNQEVEFGRNRERLQFFKWSSGAFKNVAVIPPGTGMAHQVNLEYLSRVVFEE--TD---LLFP 274

  Fly   208 DSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLT 272
            |||||||||.||:||||:|||||||||.||||||..:::.||||:|.:|.|..:..|||.|:||.
Mouse   275 DSVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVTLTLPEVVGCELTGSSNAFVTSIDIVLG 339

  Fly   273 ITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNRSEK 337
            |||||||:||.||||||:|.||::|||.||.||:||||||||.:.:||:|..||.:::.|...:.
Mouse   340 ITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLRHLEHTGFDKT 404

  Fly   338 KIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCL 402
            |::.:.:||||.:..|| .:.:.:|:::|.|.::|:::|.||||||||.|||:|:||..||::||
Mouse   405 KLESMEKYLKAVKLFRN-DENSSEPEYSQVIQINLNSIVASVSGPKRPQDRVAVTDMKSDFQACL 468

  Fly   403 SSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAV 467
            :..||||||.:|.|.||.....:: ||..|||.||||||||:.||||..||||||.|||||||||
Mouse   469 NEKVGFKGFQVAAEKQSDTVSVRY-DGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAV 532

  Fly   468 EKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIE 532
            |.||.:.|||:||||||||:||:||..|||:|||.|||||||||||.||:||:.||.|.|:|.::
Mouse   533 EIGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFDIVGYGCSTCVGNTAPLSEAVLNAVK 597

  Fly   533 KNGLVCAGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPLGVDANGKNVFLQ 597
            :..||..||||||::||||:....||||||||.||:||||||.|:|||:.||||.|:.||.::|.
Mouse   598 QGDLVTCGVLSGNKHFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDSTGKEIYLH 662

  Fly   598 DIWPTRSEIQEVENKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWSADSTYIKRPPFFEGM 662
            ||||:|.|:.::|.:|||.:||:.:..|:|:|::.|.:|:..:..||.|...||||:.|.||:.:
Mouse   663 DIWPSREEVHQMEEEHVILSMFKTLKEKVEMGNKRWNSLEAPDSVLFPWDVKSTYIRCPSFFDKL 727

  Fly   663 TRDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRDFNSYGSRRGNDA 727
            |::....|.|:.|..||:||||||||||||||||||:|.||::|:.|.:|||:|||||:||||||
Mouse   728 TKEPAASQPIENAHVLLYLGDSVTTDHISPAGSIARSSAAAKYLTNRGLTPREFNSYGARRGNDA 792

  Fly   728 IMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGTPLVLVVGKDYGSGSSRDW 792
            :|:|||||||:|.||.:.|..|:|:|.||.:.||:|:|||.|::||.||:::.||.||||:||||
Mouse   793 VMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDW 857

  Fly   793 AAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNLTGREVYNIALPESGLKPG 857
            |||||:|||||||:|||||:||:.:|:|:||.||:||||::|::|.|:||||::::.||. |.||
Mouse   858 AAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLEFLPGENADSLGLSGREVFSLSFPEE-LFPG 921

  Fly   858 QKIQVE-ADGTVFETILRFDTEVDITYYKNGGILNYMIRKML 898
            ..:.:: :.|..|..|..|..:|:||.||:||:||::.||.|
Mouse   922 ITLNIKTSTGKEFSVIASFANDVEITLYKHGGLLNFVARKFL 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	510/952 (54%)
Ireb2	NP_073146.2	PTZ00092	3..961	CDD:240263	507/948 (53%)