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Protein Alignment Irp-1B and ACO2

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001089.1	Gene:	ACO2 / 50	HGNCID:	118	Length:	780	Species:	Homo sapiens

Alignment Length:	907	Identity:	250/907 - (27%)
Similarity:	369/907 - (40%)	Gaps:	234/907 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LLESAVRNCDNFHILEKDVQSILGWSPALKQG------SNDVE-----VSFKPARVILQDFTGVP 96
            |||.      |.:|:.|.:...|..|..:..|      |.::|     :..:|.||.:||.|...
Human    47 LLEK------NINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQM 105

  Fly    97 AVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQV------DFARAPDALAKNQSLEFERNK 155
            |::.|         :.....|:  ..|:.:..||.::.      |..||.|.           |:
Human   106 AMLQF---------ISSGLSKV--AVPSTIHCDHLIEAQVGGEKDLRRAKDI-----------NQ 148

  Fly   156 ERFTFL-----KWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYPD-SVVGTD 214
            |.:.||     |:|...:.      |||||:||:.||..|               ||. .::|||
Human   149 EVYNFLATAGAKYGVGFWK------PGSGIIHQIILENYA---------------YPGVLLIGTD 192

  Fly   215 SHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLTITKHLRQ 279
            |||....|||.:..||||.:|..||.|....:..|:|||.||.|.||...:..|::|.:...|..
Human   193 SHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTV 257

  Fly   280 LGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNRSEKKIDIIRQ 344
            .|..|..||::||||..:|....|||.||..|.|||...||.:.....|:.:|.|
Human   258 KGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGR---------- 312

  Fly   345 YLKATQQLRNYADAAQDP-------KFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCL 402
                 :.:.|.||..:|.       .:.|.|.::||.:...::||..|.               |
Human   313 -----EDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPD---------------L 357

  Fly   403 SSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAV 467
            :.||...|.....|.        |.         ..:.:..|.||||:|...:...|. :||:|:
Human   358 AHPVAEVGKVAEKEG--------WP---------LDIRVGLIGSCTNSSYEDMGRSAA-VAKQAL 404

  Fly   468 EKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIE 532
            ..||....  :.:::|||..:...::..|....|..||..::...|..|||.   .:...:...|
Human   405 AHGLKCKS--QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQ---WDRKDIKKGE 464

  Fly   533 KNGLVCAGVLSGNRNFEGR--IHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPL-GVDANGKNV 594
            ||.:    |.|.||||.||  .:|.|.| ::.||.:|.|.||||.:..:.|.:.| |.|  ||..
Human   465 KNTI----VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKF 522

  Fly   595 FLQDIWPTRSEIQEVENKHVIPAMFQEVYS---KIELG-----SQDWQTLQVSEGKLFSWSADST 651
            .|:.  |...|:.:.|   ..|.  |:.|.   |...|     |...|.||:.|
Human   523 RLEA--PDADELPKGE---FDPG--QDTYQHPPKDSSGQHVDVSPTSQRLQLLE----------- 569

  Fly   652 YIKRPPFFEGMTRDLPKLQSI--QKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPR 714
                 ||.:...:||..||.:  .|.:|        ||||||.||...:
Human   570 -----PFDKWDGKDLEDLQILIKVKGKC--------TTDHISAAGPWLK---------------- 605

  Fly   715 DFNSYGSRRGNDAI-----MSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGT 774
             |..:.....|:.:     :..|...::|  |.:.::.||    :|        |.|..|::.|.
Human   606 -FRGHLDNISNNLLIGAINIENGKANSVR--NAVTQEFGP----VP--------DTARYYKKHGI 655

  Fly   775 PLVLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNL 839
            ..|::..::||.||||:.||..|..||.:|:|.:|:.|||.:||...|::||.|........::.
Human   656 RWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHP 720

  Fly   840 TGREVYNIALPESGLK---PGQKIQV---EADGTVFETILRFDT--EVDITYYKNGGILNYM 893
            ..:      |...|||   ||:.::.   ..:||. ||||...|  |..|.:::.|..||.|
Human   721 VDK------LTIQGLKDFTPGKPLKCIIKHPNGTQ-ETILLNHTFNETQIEWFRAGSALNRM 775

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.