Protein Alignment Irp-1B and ACO2

DIOPT Version :10

• Sequence 1: NP_524303.2
• Gene: Irp-1B / 41269
• FlyBaseID: FBgn0024957
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001089.1
• Gene: ACO2 / 50
• HGNCID: 118
• Length: 780
• Species: Homo sapiens
• Alignment Length: 910
• Identity: 250/910 - (27%)
• Similarity: 369/910 - (40%)
• Gaps: 240/910 - (26%)

  Fly    43 LLESAVRNCDNFHILEKDVQSILGWSPALKQG------SNDVE-----VSFKPARVILQDFTGVP 96
            |||.      |.:|:.|.:...|..|..:..|      |.::|     :..:|.||.:||.|...
Human    47 LLEK------NINIVRKRLNRPLTLSEKIVYGHLDDPASQEIERGKSYLRLRPDRVAMQDATAQM 105

  Fly    97 AVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQV------DFARAPDALAKNQSLEFERNK 155
            |::.|         :.....|:  ..|:.:..||.::.      |..||.|.           |:
Human   106 AMLQF---------ISSGLSKV--AVPSTIHCDHLIEAQVGGEKDLRRAKDI-----------NQ 148

  Fly   156 ERFTFL-----KWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYPD-SVVGTD 214
            |.:.||     |:|...:.      |||||:||:.||..|               ||. .::|||
Human   149 EVYNFLATAGAKYGVGFWK------PGSGIIHQIILENYA---------------YPGVLLIGTD 192

  Fly   215 SHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLTITKHLRQ 279
            |||....|||.:..||||.:|..||.|....:..|:|||.||.|.||...:..|::|.:...|..
Human   193 SHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWSSPKDVILKVAGILTV 257

  Fly   280 LGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNRSEKKIDIIRQ 344
            .|..|..||::||||..:|....|||.||..|.|||...||.:.....|:.:|.|
Human   258 KGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGR---------- 312

  Fly   345 YLKATQQLRNYADAAQDP-------KFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCL 402
                 :.:.|.||..:|.       .:.|.|.::||.:...::||..|.               |
Human   313 -----EDIANLADEFKDHLVPDPGCHYDQLIEINLSELKPHINGPFTPD---------------L 357

  Fly   403 SSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAV 467
            :.||...|.....|.        |.         ..:.:..|.||||:|...:...|. :||:|:
Human   358 AHPVAEVGKVAEKEG--------WP---------LDIRVGLIGSCTNSSYEDMGRSAA-VAKQAL 404

  Fly   468 EKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIE 532
            ..||....  :.:::|||..:...::..|....|..||..::...|..|||.   .:...:...|
Human   405 AHGLKCKS--QFTITPGSEQIRATIERDGYAQILRDLGGIVLANACGPCIGQ---WDRKDIKKGE 464

  Fly   533 KNGLVCAGVLSGNRNFEGR--IHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPL-GVDANGKNV 594
            ||.:    |.|.||||.||  .:|.|.| ::.||.:|.|.||||.:..:.|.:.| |.|  ||..
Human   465 KNTI----VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDYLTGTD--GKKF 522

  Fly   595 FLQDIWPTRSEIQEVENKHVIPAMF---QEVYS---KIELG-----SQDWQTLQVSEGKLFSWSA 648
            .|:.  |...|:.:.|        |   |:.|.   |...|     |...|.||:.|
Human   523 RLEA--PDADELPKGE--------FDPGQDTYQHPPKDSSGQHVDVSPTSQRLQLLE-------- 569

  Fly   649 DSTYIKRPPFFEGMTRDLPKLQSI--QKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNI 711
                    ||.:...:||..||.:  .|.:|        ||||||.||...:
Human   570 --------PFDKWDGKDLEDLQILIKVKGKC--------TTDHISAAGPWLK------------- 605

  Fly   712 TPRDFNSYGSRRGNDAI-----MSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYRE 771
                |..:.....|:.:     :..|...::|  |.:.::.||    :|        |.|..|::
Human   606 ----FRGHLDNISNNLLIGAINIENGKANSVR--NAVTQEFGP----VP--------DTARYYKK 652

  Fly   772 EGTPLVLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAET 836
            .|...|::..::||.||||:.||..|..||.:|:|.:|:.|||.:||...|::||.|........
Human   653 HGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNK 717

  Fly   837 LNLTGREVYNIALPESGLK---PGQKIQV---EADGTVFETILRFDT--EVDITYYKNGGILNYM 893
            ::...:      |...|||   ||:.::.   ..:||. ||||...|  |..|.:::.|..||.|
Human   718 IHPVDK------LTIQGLKDFTPGKPLKCIIKHPNGTQ-ETILLNHTFNETQIEWFRAGSALNRM 775

  Fly   894  893
            Human   776  775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	250/910 (27%)
ACO2	NP_001089.1	aconitase_mito	45..775	CDD:273561	249/908 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..560		7/39 (18%)