Protein Alignment Irp-1B and ACO1

DIOPT Version :10

• Sequence 1: NP_524303.2
• Gene: Irp-1B / 41269
• FlyBaseID: FBgn0024957
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_047279386.1
• Gene: ACO1 / 48
• HGNCID: 117
• Length: 897
• Species: Homo sapiens
• Alignment Length: 896
• Identity: 609/896 - (67%)
• Similarity: 738/896 - (82%)
• Gaps: 12/896 - (1%)

  Fly     4 ANPFAQFEKTFSQAGTTYKYFDLASI-DSKYDQLPYSIRVLLESAVRNCDNFHILEKDVQSILGW 67
            :||||...:.........|:|:|..: ||:|.:||:|||||||:|:||||.|.:.::|:::||.|
Human    10 SNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHW 74

  Fly    68 SPALKQGSNDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSV 132
            :  :.|..| :||.|||||||||||||||||||||||||||..||||||||||:||||||||||:
Human    75 N--VTQHKN-IEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSI 136

  Fly   133 QVDFARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFEND 197
            ||||.|..|:|.|||.||||||:|||.|||||::||:||.|:||||||:|||||||||||||:.|
Human   137 QVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQD 201

  Fly   198 ATDGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSP 262
            .     ..||||:||||||||||:|||:|||||||||||||||||.|||:||:||||:|.||..|
Human   202 G-----YYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHP 261

  Fly   263 LVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLG 327
            ||||||:||||||||||:|||||||||:|||||:|||||||||:|||||||||..:||:||.::.
Human   262 LVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIT 326

  Fly   328 YMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRVSVS 392
            |:.||.|.|:|:..|::||:|....|::.|.:|||.|||.:.|||.|||...||||||.|:|:||
Human   327 YLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVS 391

  Fly   393 DMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVML 457
            ||.:||:|||.:..|||||.:|||..:....|.:|:.: :.|.||||||||||||||||||||||
Human   392 DMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTE-FTLAHGSVVIAAITSCTNTSNPSVML 455

  Fly   458 GAGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGP 522
            ||||||||||:.||:::||||||||||||||||||:||||:|||.:||||:||||||||||||||
Human   456 GAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGP 520

  Fly   523 LEENVVNTIEKNGLVCAGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPLGV 587
            |.|.||..|.:..||..||||||||||||:||||||||||||.|||||||||.:.||||||||||
Human   521 LPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGV 585

  Fly   588 DANGKNVFLQDIWPTRSEIQEVENKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWSADSTY 652
            :|.|:.|||:||||||.|||.||.::|||.||:|||.|||..::.|..|.....|||.|::.|||
Human   586 NAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTY 650

  Fly   653 IKRPPFFEGMTRDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRDFN 717
            ||.|||||.:|.||...:||..|..||.||||||||||||||:|||.|||||:|:.|.:|||:||
Human   651 IKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFN 715

  Fly   718 SYGSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGTPLVLVVGK 782
            ||||||||||:|:|||||||||:|:.:.|..|:|:|:||.|.||:|||||||::.|.||:::.||
Human   716 SYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGK 780

  Fly   783 DYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNLTGREVYNI 847
            :||:|||||||||||||||:|||:||||||||||||||||:|||::|||::|:.|.|||:|.|.|
Human   781 EYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTI 845

  Fly   848 ALPESGLKPGQKIQVEAD-GTVFETILRFDTEVDITYYKNGGILNYMIRKM 897
            .:||: |||..|:||:.| |..|:.::||||:|::||:.||||||||||||
Human   846 IIPEN-LKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKM 895

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	609/896 (68%)
ACO1	XP_047279386.1	PTZ00092	10..897	CDD:240263	609/896 (68%)