DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and mAcon1

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001097186.2	Gene:	mAcon1 / 44149	FlyBaseID:	FBgn0010100	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	251/911 - (27%)
Similarity:	378/911 - (41%)	Gaps:	218/911 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SKYDQ---LPY-SIRVLLESAVRNCDN--FHILEKDVQSILGWSPA---LKQGSNDVEVSFKPAR 86
            ||:|.   ||| .:...|| .||...|  ..:.||.:.|.|. .||   :.:|::.:.:  :|.|
  Fly    42 SKFDSDVYLPYEKLNKRLE-VVRGRLNRPLTLSEKVLYSHLD-DPANQDIVRGTSYLRL--RPDR 102

  Fly    87 VILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQVDFARAPDALAKNQSLEF 151
            |.:||.|...|::.|         :....:|:  ..|:.:..||.::.... .|..||:.:.|
  Fly   103 VAMQDATAQMALLQF---------ISSGLKKV--AVPSTVHCDHLIEAQIG-GPKDLARAKDL-- 153

  Fly   152 ERNKERFTFL-----KWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYPDSVV 211
              |||.:.||     |:|...:.      |||||:||        ::.||.|..|  :|    ::
  Fly   154 --NKEVYDFLASTCAKYGLGFWK------PGSGIIHQ--------IILENYAFPG--LL----MI 196

  Fly   212 GTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLTITKH 276
            ||||||....|||.|..||||.:|..||......:..|:|||..|.||:|...:..|::|.:...
  Fly   197 GTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDVILKVADI 261

  Fly   277 LRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNR----SEK 337
            |...|..|..:|::|.||..:|....|||.||..|.|||...||.::....|:|.|.|    ||
  Fly   262 LTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTGRAGIASE- 325

  Fly   338 KIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCL 402
                      |.:.......|.::.::.:.|.::|.|:...|:||..|.               |
  Fly   326 ----------AQKYQAKILSADKNCEYDELIEINLDTLEPHVNGPFTPD---------------L 365

  Fly   403 SSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAV 467
            ..|:            |..||....:|  |.:   .:.:..|.||||:|... |.....:||.|:
  Fly   366 GHPI------------SKLGENSKKNG--YPM---DIRVGLIGSCTNSSYED-MGRCASIAKDAM 412

  Fly   468 EKGL-SILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTI 531
            ..|| |.:|:   :::|||..:...::..|:....:|.|..::...|..|||.   .:...|...
  Fly   413 SHGLKSKIPF---NVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQ---WDRKDVKKG 471

  Fly   532 EKNGLVCAGVLSGNRNFEGRIHPNTRAN-YLASPLLVIAYAIAGRVDIDFEKEPLGVDANGKNVF 595
            :||.:    |.|.||||.||...|...: ::.||.||.|.:||||:|.:...:.| ..|:||
  Fly   472 DKNTI----VTSYNRNFTGRNDANPATHCFVTSPELVTALSIAGRLDFNPLTDEL-TGADGK--- 528

  Fly   596 LQDIWPTRSEIQEVENKHVIPAMF-QEVYSKIELGSQDWQTLQVSEGKLFSWSAD--STYIK-RP 656
                            |..:.|.| .|:.:|.....||..|.....|:....:.|  ||.:: ..
  Fly   529 ----------------KFKLKAPFGDELPAKGFDPGQDTYTAPPPSGENVKVAVDPKSTRLQLLE 577

  Fly   657 PFFEGMTRDLPKLQSI--QKARCLLFLGDSVTTDHISPAG----------SIARTSPAARFLSER 709
            ||.:...:||..|..:  .|.:|        ||||||.||          :|:..    .|:...
  Fly   578 PFDKWNGQDLTDLTVLIKVKGKC--------TTDHISAAGPWLKYRGHLDNISNN----MFIGAT 630

  Fly   710 NITPRDFNSYGSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGT 774
            |....:.|:..::|       .|::..:.                         |.|..|:..|.
  Fly   631 NYENNEMNNIKNQR-------NGSWGGVP-------------------------DVARDYKANGI 663

  Fly   775 PLVLVVGKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFL---------P 830
            ..|.|..::||.||||:.||..|..||.:|:|.:|:.|||.:||...|::||.|.         |
  Fly   664 KWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFANPADYDKIQP 728

  Fly   831 GQSAETLNLTGREVYNIALPESGLKPGQKIQVE-ADGTVFETILRFDT--EVDITYYKNGGILNY 892
            ......|||            ..|.||:.:..| .:|...|.|....|  ::.|.::|.|..||.
  Fly   729 TSKISLLNL------------KSLAPGKPVDAEIKNGDKVERIKLNHTLNDLQIGWFKAGSALNR 781

  Fly   893 M 893
            |
  Fly   782 M 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	251/911 (28%)
		AcnA_IRP	86..576	CDD:153136	146/500 (29%)
		AcnA_IRP_Swivel	680..849	CDD:238812	47/187 (25%)
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	245/899 (27%)
		AcnA_Mitochondrial	102..513	CDD:153134	146/500 (29%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	50/203 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451298
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750