DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and Irp-1A

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster

Alignment Length:	898	Identity:	787/898 - (87%)
Similarity:	847/898 - (94%)	Gaps:	1/898 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SGANPFAQFEKTFSQAGTTYKYFDLASIDSKYDQLPYSIRVLLESAVRNCDNFHILEKDVQSILG 66
            |||||||||:::|:|.|..||||||.||||||:.||:|||||||||||||||||:||||||||||
  Fly     4 SGANPFAQFQESFTQDGNVYKYFDLPSIDSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILG 68

  Fly    67 WSPALKQGSNDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHS 131
            |:|:|||.::||||||||||||||||||||||||||||||||.:|||:|||||||||||||||||
  Fly    69 WTPSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHS 133

  Fly   132 VQVDFARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFEN 196
            |||||.|:.|||.||:||||:|||||||||||||:||:||||||||||||||||||||||||||:
  Fly   134 VQVDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFES 198

  Fly   197 DAT-DGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKL 260
            |:: |||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||
  Fly   199 DSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKL 263

  Fly   261 SPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENT 325
            .||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   264 GPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENT 328

  Fly   326 LGYMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRVS 390
            |.||:|||||||||||||:|||||:|||:|:...|||::|:|:||||||||||||||||||||||
  Fly   329 LSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRVS 393

  Fly   391 VSDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSV 455
            ||.|.|||||||.||||||||||.|.|.:|.|||||||||:||:.||||||||||||||||||||
  Fly   394 VSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSV 458

  Fly   456 MLGAGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNS 520
            |||||||||.||:||||||||||||||||||||||||:|||||||||:|||||||||||||||||
  Fly   459 MLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNS 523

  Fly   521 GPLEENVVNTIEKNGLVCAGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPL 585
            |||:||||||||||||||.||||||||||||||||||||||||||||||||||||||||||.|||
  Fly   524 GPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPL 588

  Fly   586 GVDANGKNVFLQDIWPTRSEIQEVENKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWSADS 650
            |||:|||.|||:|||||||||||||:|||||||||||||||:|||:|||||:||:.||:.||..|
  Fly   589 GVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEIS 653

  Fly   651 TYIKRPPFFEGMTRDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRD 715
            ||||.|||||||||.||||:.|:||||||.||||||||||||||||||.|||||:||||.:||||
  Fly   654 TYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRD 718

  Fly   716 FNSYGSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGTPLVLVV 780
            ||||||||||||:|:|||||||||||||..||||.|:|:||.||:|||||||||..|||||||||
  Fly   719 FNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVV 783

  Fly   781 GKDYGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNLTGREVY 845
            |||||||||||||||||||||:||||||||||||||||||||||||||||||||:||.|:|||||
  Fly   784 GKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVY 848

  Fly   846 NIALPESGLKPGQKIQVEADGTVFETILRFDTEVDITYYKNGGILNYMIRKML 898
            ||.|||..|||||:|||:|||.||||.||||||||||||||||||||||||||
  Fly   849 NIVLPEGELKPGQRIQVDADGNVFETTLRFDTEVDITYYKNGGILNYMIRKML 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	787/898 (88%)
		AcnA_IRP	86..576	CDD:153136	442/490 (90%)
		AcnA_IRP_Swivel	680..849	CDD:238812	148/168 (88%)
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	785/896 (88%)
		AcnA_IRP	88..579	CDD:153136	442/490 (90%)
		AcnA_IRP_Swivel	683..852	CDD:238812	148/168 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472951
Domainoid	1	1.000	643	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG1048
Homologene	1	1.000	-	-		H1657
Inparanoid	1	1.050	1070	1.000	Inparanoid score	I33
Isobase	1	0.950	-	0	Normalized mean entropy	S1246
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	1	1.000	-	-		otm26625
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	P	PTHR11670
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2385
SonicParanoid	1	1.000	-	-		X803
	15	14.790