DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and mAcon2

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_650042.2	Gene:	mAcon2 / 41326	FlyBaseID:	FBgn0037862	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	951	Identity:	257/951 - (27%)
Similarity:	374/951 - (39%)	Gaps:	254/951 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AGTTYKYFDLASIDSKYDQLPYSIRVLLESAVRN--------CD-----NFHI--------LEKD 60
            |..|::|..||.                 |.|||        ||     ||..        |.::
  Fly     2 AQRTHRYICLAG-----------------SMVRNFHTARFPRCDKVAMSNFDTGIPLPYKKLREN 49

  Fly    61 VQSILG-------------WSPALKQGSNDVE-----VSFKPARVILQDFTGVPAVVDFAAMRDA 107
            :..|.|             :|...:..|.::|     :..:|.||.|||.|....::.|
  Fly    50 LDCIKGRLGGPLTLSEKVLYSHLDQPDSQEIERGKSYLRLRPDRVALQDATAQMTLLQF------ 108

  Fly   108 VLDLGGDPEKINPICPADLVIDHSVQV------DFARAPDALAKNQSLEFERNKERFTFLKWGAK 166
               :....:|:  ..|:.:..||.::.      |.|||.|.           |||.:.||. .|.
  Fly   109 ---ISSGLKKV--AVPSTVHCDHLIEAQISGDKDLARAKDL-----------NKEVYDFLS-SAC 156

  Fly   167 AFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYPDSVVGTDSHTTMINGLGVLGWGVG 231
            |..|:....|||||:||        ::.||.|..|  :|    ::||||||....|||.|..|||
  Fly   157 AKYNLGFWKPGSGIIHQ--------IILENYAFPG--LL----MIGTDSHTPNGGGLGCLCVGVG 207

  Fly   232 GIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAE 296
            |.:|..||......:..|.|||..|.||:|...:..|::|.:.:.|...|..|..||::||||..
  Fly   208 GADAVDVMANIPWELKCPTVIGCHLTGKISGWTSPKDVILKVAEILTVKGGTGAIVEYHGPGVES 272

  Fly   297 LSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQD 361
            :|....|||:||..|.|||...||.:|..:.|::.|.|.          ..|.:..:|......|
  Fly   273 ISCTGMATITNMGAEIGATTSIFPFNERMVTYLRATGRG----------AIADEATKNKDLLVPD 327

  Fly   362 P--KFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEF 424
            .  |:.:.|.::|.|:...|:||..|.               |:.|:            |..|:.
  Fly   328 EGCKYDKVIEINLDTLEPLVNGPFTPD---------------LAHPI------------SKLGQN 365

  Fly   425 QWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEKGL-SILPYIKTSLSPGSGVV 488
            ...:|  |.:   .:.::.|.||||:|... |.....:|..|:..|| |.:|:   :::|||..|
  Fly   366 SEKNG--YPM---EIKVSLIGSCTNSSYED-MGRCASIANDALGHGLKSCVPF---NVTPGSEQV 421

  Fly   489 TYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIEKNGLVCAGVLSGNRNFEGRIH 553
            ...:...|:|..|||.|..::...|..|||.   .:...|...|||.:    |.|.||||.||..
  Fly   422 RATIARDGIIDVLEKFGGTVLANACGPCIGQ---WDRKDVKMGEKNTI----VTSYNRNFTGRND 479

  Fly   554 PNTRAN-YLASPLLVIAYAIAGRVDID-FEKEPLGVDANGKNVFLQDIWPTRSEIQE------VE 610
            .|...: ::.||.:..|.|||||:|.: ...|..|.|  ||...|::  |...|:..      .:
  Fly   480 ANPATHCFVTSPEMATALAIAGRLDFNPMTDELTGTD--GKTFKLKE--PHGEELPSKGFDPGED 540

  Fly   611 NKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWSADSTYIKRPPFFEGMTRDLPKLQSIQKA 675
            .....||...::...::..|...|.|:..|    .|.. ..||           ||..|..| |.
  Fly   541 TYQAPPAKADDIKVNVDPKSDRLQLLEPFE----KWDG-KDYI-----------DLMVLIKI-KG 588

  Fly   676 RCLLFLGDSVTTDHISPAGSIARTSPAARFLSE-RNITPRDFNSYGSRRGNDAIMSRGTFANIRL 739
            :|        ||||||.||      |..::... .||:...|....:...|:
  Fly   589 KC--------TTDHISAAG------PWLKYRGHLDNISNNMFIGATNAENNE------------- 626

  Fly   740 VNKLV-EKTGPRTVHIPSQEELDIFDA----AERYREEGTPLVLVVGKDYGSGSSRDWAAKGPFL 799
            :||:. :|||.             |||    |..|:........|..::||.||||:.||..|..
  Fly   627 MNKVKNQKTGS-------------FDAVPAVARDYKANKIKWCAVGEENYGEGSSREHAALEPRH 678

  Fly   800 LGVKAVIAESYERIHRSNLVGMGIIPLQFL---------PGQSAETLNLTGREVYNIALPESGLK 855
            ||..|:|.:|:.|||.:||...|::.|.|.         |......|||            ..|.
  Fly   679 LGGVAIIVKSFARIHETNLKKQGMLALTFANPGDYDKVQPSSKISILNL------------KDLA 731

  Fly   856 PGQKIQVEADGTVFETILRFD---TEVDITYYKNGGILNYM 893
            ||:.:..|.........::.:   .|:.|.:::.|..||.|
  Fly   732 PGKPVDAEIKNNGSSDKIQLNHTLNELQIQWFQAGSALNLM 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	257/951 (27%)
		AcnA_IRP	86..576	CDD:153136	152/499 (30%)
		AcnA_IRP_Swivel	680..849	CDD:238812	50/183 (27%)
mAcon2	NP_650042.2	aconitase_mito	43..772	CDD:273561	243/891 (27%)
		AcnA_Mitochondrial	93..503	CDD:153134	152/499 (30%)
		Aconitase_swivel	585..733	CDD:294147	54/200 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750