DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and aco2

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_944590.1	Gene:	aco2 / 322670	ZFINID:	ZDB-GENE-030131-1390	Length:	782	Species:	Danio rerio

Alignment Length:	901	Identity:	251/901 - (27%)
Similarity:	364/901 - (40%)	Gaps:	236/901 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NFHILEKDVQSILGWSPALKQGSND-----------VEVSFKPARVILQDFTGVPAVVDFAAMRD 106
            |..|:.|.:...|..|..:..|..|           ..:..:|.||.:||.|...|::.|.:
Zfish    53 NIDIVRKRLNRPLTLSEKIVYGHLDDPAGQEIARGRTYLRLRPDRVAMQDATAQMAMLQFIS--- 114

  Fly   107 AVLDLGGDPEKINPICPADLVIDHSVQVDFARAPDALAKNQSLEFERNKERFTFL-----KWGAK 166
                 .|.|:   ...|:.:..||.::.....|.| |.|.:    |.|:|.::||     |:|..
Zfish   115 -----SGLPK---VAVPSTIHCDHLIEAQTGGAQD-LQKAK----EVNQEVYSFLASAGAKYGVG 166

  Fly   167 AFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYPD-SVVGTDSHTTMINGLGVLGWGV 230
            .:.      |||||:||:.||..|               ||. .::||||||....|||.:..||
Zfish   167 FWK------PGSGIIHQIILENYA---------------YPGVMLIGTDSHTPNGGGLGCICIGV 210

  Fly   231 GGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVA 295
            ||.:|..||.|....:..|.|||.||.|.||...:..|::|.:...|......|..||::||||.
Zfish   211 GGADAVDVMAGIPWELKCPNVIGVKLTGSLSGWSSPKDVILKVAGILTVKRGTGAIVEYHGPGVD 275

  Fly   296 ELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNRSEKKIDIIRQYLKATQQLRNYADAAQ 360
            .:|....|||.||..|.|||...||.:.....|:.:|.|.|               :...||..:
Zfish   276 SISCTGMATICNMGAEIGATTSVFPFNHRMKTYLDKTGRGE---------------IATLADENK 325

  Fly   361 D---P----KFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCLSSPVGFKGFAIAPEAQ 418
            |   |    .:.|.|.::|..:...::||..|.....|||        :.|.....|:.:
Zfish   326 DLLVPDSGCHYDQLIEINLDELKPHINGPFTPDLAHPVSD--------IGSVAEKNGWPL----- 377

  Fly   419 SAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVEKGLSILPYIKTSLSP 483
                               .|.:..|.||||:|... |..|..|||:|::|||..  ..:.:::|
Zfish   378 -------------------DVKVGLIGSCTNSSYED-MGRAASLAKQALDKGLKC--KAQFTVTP 420

  Fly   484 GSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIEKNGLVCAGVLSGNRNF 548
            ||..:...::..|....|..:|..::...|..|||.   .:...|...|||.:    |.|.||||
Zfish   421 GSEQIRATIERDGYAKVLRDVGGIVLANACGPCIGQ---WDRRDVKKGEKNTI----VTSFNRNF 478

  Fly   549 EGR--IHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPLGVDANGKNVFLQDIWPTRSEIQEVEN 611
            ..|  .:|.|.| ::.||.:|.|.||||.:..:.|.:.| ...||:...|:.  ||..|
Zfish   479 TARNDANPATHA-FVTSPEIVTALAIAGTLKFNPETDYL-TAPNGEKFKLEP--PTGDE------ 533

  Fly   612 KHVIPAM----FQEVYS---------KIELGSQDWQTLQVSEGKLFSWSADSTYIKRPPFFEGMT 663
               :||.    .|:.|.         |:::..|. ..||:.|                ||.:...
Zfish   534 ---LPARDFDPGQDTYQHPPADGSALKVDVNPQS-NRLQLLE----------------PFDKWNG 578

  Fly   664 RDLPKLQSI--QKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRDFNSYGSRRGN- 725
            :||..||.:  .|.:|        ||||||.||      |..:|                 ||:
Zfish   579 KDLEDLQVLIKVKGKC--------TTDHISAAG------PWLKF-----------------RGHL 612

  Fly   726 DAIMSRGTFANIRLVNKLVEK-----TGPRTVHIPSQEELDIFDAAERYREEGTPLVLVVGKDYG 785
            |.|.:......:.:.|..|.|     ||         |...:.|.|..|::.....|:|..::||
Zfish   613 DNISNNLLIGAVNIENDGVNKLRNLLTG---------EYSGVPDVARHYKKNNISWVVVGDENYG 668

  Fly   786 SGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNLTGREVYNIALP 850
            .||||:.||..|..||.:|:|.:|:.|||.:||...|::||.|  ...|:         |:...|
Zfish   669 EGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTF--SNPAD---------YDKIRP 722

  Fly   851 ES-----GLK---PGQKIQV---EADGTVFETILRFDT--EVDITYYKNGGILNYM 893
            :.     |||   ||:.::.   ..||: .|||....|  |..|.:::.|..||.|
Zfish   723 DDKISIIGLKSFAPGKPLKAVIKHTDGS-SETIELNHTFNETQIEWFQAGSALNRM 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	251/901 (28%)
		AcnA_IRP	86..576	CDD:153136	150/504 (30%)
		AcnA_IRP_Swivel	680..849	CDD:238812	50/174 (29%)
aco2	NP_944590.1	aconitase_mito	47..777	CDD:273561	250/899 (28%)
		AcnA_Mitochondrial	97..507	CDD:153134	150/504 (30%)
		AcnA_Mitochon_Swivel	589..737	CDD:238810	56/198 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820