DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1B and SPBP4H10.15

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_596189.3	Gene:	SPBP4H10.15 / 2541348	PomBaseID:	SPBP4H10.15	Length:	918	Species:	Schizosaccharomyces pombe

Alignment Length:	960	Identity:	250/960 - (26%)
Similarity:	384/960 - (40%)	Gaps:	268/960 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AQFEKTFSQAG-TTYKYFDLASIDSKYDQ----LPYSIRVLLESAVRNCDNFHILEKDVQSILGW 67
            |:|:.|.|:|. .|..|..|.   .|..|    ||.....|.|..:.:    |::..: :|..|.
pombe    28 ARFQSTASRASYVTPPYEKLM---GKLQQVRKFLPGQKLTLAEKVLYS----HLVNPE-ESFSGV 84

  Fly    68 SPALKQGSNDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSV 132
            ||:..:||  :.:...|.||.:||.:...|::.|       :..|.:...|    ||.:..||.:
pombe    85 SPSDIRGS--LYLKLNPDRVAMQDASAQMALLQF-------MTCGLEKTMI----PASIHCDHLI 136

  Fly   133 QVDFARA----PDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVV 193
             |....|    ||::|        .|||.|.||:..||.: .:....|||||:||        :|
pombe   137 -VGHRGANSDIPDSIA--------NNKEIFDFLQSAAKKY-GIQFWGPGSGIIHQ--------IV 183

  Fly   194 FENDATDGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEG 258
            .||.|..|..:|      ||||||....|||::..||||.:|...|......:..|::||..|.|
pombe   184 LENYAAPGGMML------GTDSHTPNAGGLGMIAIGVGGADAVDAMTNTPWELKAPKIIGVNLTG 242

  Fly   259 KLSPLVTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDE 323
            .:|...|..||:|.:...|...|..|..:|::|||||.||....||:.||..|.|||...||..:
pombe   243 AMSGWTTPKDLILHLAGKLTVRGGTGHIIEYFGPGVASLSCTGMATVCNMGAEVGATTSIFPYTD 307

  Fly   324 NTLGYMKQTNRSE---KKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRP 385
            :...|:..|:|:|   ...::..:|        ||..|....|:.|.|.::||.:..|::||..|
pombe   308 SMRRYLIATHRAEVADAASEVHSEY--------NYLAADTGAKYDQIIDINLSELTPSLNGPFTP 364

  Fly   386 HDRVSVSDMPEDFKSCLSSPVGFKGFAIAPEAQSAFGEF----QWDDGKTYKLHHGSVVIAAITS 446
            .               ||:||            |.|||.    :|..    ||..|     .|.|
pombe   365 D---------------LSTPV------------SKFGEAIEKNKWPK----KLSAG-----LIGS 393

  Fly   447 CTNTSNPSVMLGAGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGY 511
            |||:|...:.....:: ::|:..||.  |.:...::|||..:...::..|:...||:.|..::..
pombe   394 CTNSSYQDMTCVVDVV-EQAISAGLK--PKVPFLVTPGSEQIRATIERDGITERLEEAGATVLAN 455

  Fly   512 GCMTCIG--------NSGPLEENVVNTIEKNGLVCAGVLSGNRNFEGRI--HPNTRANYLASPLL 566
            .|..|||        .||  |.|.:.|            |.||||..|.  :|:| .|:|.||::
pombe   456 ACGPCIGMWKRTDDIASG--EPNAILT------------SFNRNFRSRNDGNPST-MNFLTSPVI 505

  Fly   567 VIAYAIAGRVDIDFEKEPLGVDANGKNVFLQDIWPTRSEIQEVENKHVIPAMFQEVYSKIELGSQ 631
            |.|...:.  |:.|:                   ||.
pombe   506 VAAKIFSS--DLAFD-------------------PTH---------------------------- 521

  Fly   632 DWQTLQVSEGKLFSW--------------SADSTYIKRP-----------------------PF- 658
              .|||..:||.|.:              :.||:||..|                       ||
pombe   522 --DTLQTPDGKAFKFRPPQGVELPSAGFIAGDSSYIPEPNPQPVPETEVTIDPKSDRLEALEPFE 584

  Fly   659 -FEGMTRDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRDFNSYGSR 722
             ::|...:..|:....|.:|        ||||||.||.                    :..|...
pombe   585 PYQGGEMENLKVAVKVKGKC--------TTDHISAAGK--------------------WLKYKGH 621

  Fly   723 RGNDAIMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGTPLVLVVGKDYGSG 787
            ..|        ..|..|:..:...||.......:.:.:.|.:...:::::|.|.::|...:||.|
pombe   622 LSN--------ICNNTLIGAMNAATGEVNRAYDNGKGMTIPELMWKWKKDGQPWLVVAEHNYGEG 678

  Fly   788 SSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLN----LTGREVYNIA 848
            |:|:.||..|..:..:.::.:|:.|||.:||...|::||.|:.....|.::    ::.|.:..
pombe   679 SAREHAALQPRAMNGRIILTKSFARIHETNLKKQGVLPLTFVNEADYEKIDAEDKVSTRGIEQ-- 741

  Fly   849 LPESGL-KPGQKIQVEADGTVFETILRFDTEVD-ITYYKNGGILNYMIRK 896
            |.|..| :|...:..:.||:|.|...:.....| |.::|.|..|| :||:
pombe   742 LLEGVLDQPITLVVTKKDGSVVEIPCKHTMSKDQIEFFKAGSALN-LIRE 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	250/960 (26%)
		AcnA_IRP	86..576	CDD:153136	153/510 (30%)
		AcnA_IRP_Swivel	680..849	CDD:238812	38/172 (22%)
SPBP4H10.15	NP_596189.3	aconitase_mito	44..788	CDD:273561	242/940 (26%)
		Aconitase	101..515	CDD:294203	153/512 (30%)
		Aconitase_swivel	599..745	CDD:294147	41/183 (22%)
		Ribosomal_L21p	820..908	CDD:279202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61122
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X803
TreeFam	0	0.000	Not matched by this tool.
	4	3.820