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Protein Alignment Irp-1B and Aco1

DIOPT Version :9

Sequence 1:	NP_524303.2	Gene:	Irp-1B / 41269	FlyBaseID:	FBgn0024957	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_031412.2	Gene:	Aco1 / 11428	MGIID:	87879	Length:	889	Species:	Mus musculus

Alignment Length:	895	Identity:	615/895 - (68%)
Similarity:	732/895 - (81%)	Gaps:	12/895 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NPFAQFEKTFSQAGTTYKYFDLASI-DSKYDQLPYSIRVLLESAVRNCDNFHILEKDVQSILGWS 68
            ||||...:....|....::|:|..: ||:|.:||:|||||||:||||||.|.:.:.|:::||.|:
Mouse     3 NPFAHLAEPLDAAQPGKRFFNLNKLEDSRYGRLPFSIRVLLEAAVRNCDEFLVKKNDIENILNWN 67

  Fly    69 PALKQGSNDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQ 133
              :.|..| :||.|||||||||||||||||||||||||||..|||:||||||:||||||||||:|
Mouse    68 --VMQHKN-IEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVCPADLVIDHSIQ 129

  Fly   134 VDFARAPDALAKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDA 198
            |||.|..|:|.|||.||||||||||.|||||::||.||.|:||||||:|||||||||||||:.|.
Mouse   130 VDFNRRADSLQKNQDLEFERNKERFEFLKWGSQAFCNMRIIPPGSGIIHQVNLEYLARVVFDQDG 194

  Fly   199 TDGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPL 263
                 ..||||:||||||||||:|||||||||||||||||||||.|||:||:||||||.||..||
Mouse   195 -----CYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKLMGKPHPL 254

  Fly   264 VTSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGY 328
            |||||:||||||||||:|||||||||:|||||:|||||||||:|||||||||..:||:||.::.|
Mouse   255 VTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSIAY 319

  Fly   329 MKQTNRSEKKIDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRVSVSD 393
            :.||.|.|.|:..|::||:|....|::.|.:|||.|||.:.|||.|||...||||||.|:|:||:
Mouse   320 LLQTGREEDKVKHIQKYLQAVGMFRDFNDTSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSE 384

  Fly   394 MPEDFKSCLSSPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLG 458
            |.:||:|||.:..|||||.:||:..:....|.:.:.: :.|.|||||||||||||||||||||||
Mouse   385 MKKDFESCLGAKQGFKGFQVAPDRHNDRKTFLYSNSE-FTLAHGSVVIAAITSCTNTSNPSVMLG 448

  Fly   459 AGLLAKKAVEKGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPL 523
            ||||||||||.|||:.||||||||||||||||||:||||:|||.:||||:|||||||||||||||
Mouse   449 AGLLAKKAVEAGLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPL 513

  Fly   524 EENVVNTIEKNGLVCAGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPLGVD 588
            .|.||..|.:..||..||||||||||||:||||||||||||.|||||||||.|.||||||||||:
Mouse   514 PEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTVRIDFEKEPLGVN 578

  Fly   589 ANGKNVFLQDIWPTRSEIQEVENKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWSADSTYI 653
            |.|:.|||:||||||.|||.||.:||||.||:|||.|||..::.|..|.....||::|:..||||
Mouse   579 AQGRQVFLKDIWPTRDEIQAVERQHVIPGMFKEVYQKIETVNKSWNALAAPSEKLYAWNPKSTYI 643

  Fly   654 KRPPFFEGMTRDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRDFNS 718
            |.|||||.:|.||...:||..|..||.||||||||||||||:|||.|||||:|:.|.:|||:|||
Mouse   644 KSPPFFESLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNS 708

  Fly   719 YGSRRGNDAIMSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGTPLVLVVGKD 783
            |||||||||||:|||||||||:||.:.|..|:|||:||.|.||:|||||||::.|.||:::.||:
Mouse   709 YGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETLDVFDAAERYQQAGLPLIVLAGKE 773

  Fly   784 YGSGSSRDWAAKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNLTGREVYNIA 848
            ||||||||||||||||||:|||:||||||||||||||||:|||::|||::|::|.|||||.|.|.
Mouse   774 YGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGETADSLGLTGRERYTIN 838

  Fly   849 LPESGLKPGQKIQVEAD-GTVFETILRFDTEVDITYYKNGGILNYMIRKM 897
            :||. |||...:|::.| |..|:.::||||:|::||:.||||||||||||
Mouse   839 IPED-LKPRMTVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKM 887

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.