DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rfx and RFX1

DIOPT Version :9

Sequence 1:	NP_001247023.2	Gene:	Rfx / 41266	FlyBaseID:	FBgn0020379	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_013277.1	Gene:	RFX1 / 850873	SGDID:	S000004166	Length:	811	Species:	Saccharomyces cerevisiae

Alignment Length:	576	Identity:	126/576 - (21%)
Similarity:	223/576 - (38%)	Gaps:	115/576 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 LYHSNSSQTQMTYPFCP--VGDYQGNGQ--------TAYYSTTGQYGTTS--SAGGSSNGAHSTT 279
            |.|.:|.:.:...|..|  :|...|:.:        .|..:|..|..|.|  .|..|.|.::|:.
Yeast   111 LLHQSSPRPETPNPILPPLIGSGPGSHKPSPTPTQPPAQPATQRQPATYSVYPASISLNRSNSSA 175

  Fly   280 LPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPHSLTVSSRDWERDAD--RVNGTNRHWVQEVAY 342
            .|.....||         :|:.:...:..|.:......||...::.:.  |::..:|...||:..
Yeast   176 YPLSFKSEE---------TLNNNPPTAAKRTNTFPSIPSSTKKQKTSQEKRISSISRRNTQEIIA 231

  Fly   343 IQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQSA-----LGSSNKIASA---TIKWLSR 399
            .|.|::. ::.|............:..    .|.||..::     |...|:....   .:.||.:
Yeast   232 KQIAENN-KSKTIEEYAQIVKHAEIKV----LSMDSQNTSKAALQLAEQNRERERQVFALLWLMK 291

  Fly   400 NYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGI 464
            |.::.....:||..::..|...||::.|:|::.||.|||||:||..|.|||||.||.|||||.|:
Yeast   292 NCKSQHDSYVPRGKIFAQYASSCSQNNLKPLSQASLGKLIRTVFPDLTTRRLGMRGQSKYHYCGL 356

  Fly   465 RIKPG-----SLLNSQAM------DDKQMLAAGYGPSSDGTGGPG-SGPM------VSVTSSTAG 511
            ::...     ||.|:.|.      :|.....:...|||.....|. |.|.      :|.|.|...
Yeast   357 KLTVNESGSVSLNNNNASLSLVHNNDPISPLSSPSPSSPSPQVPNVSSPFSLNRKSLSRTGSPVK 421

  Fly   512 QLTGSNGLGGGHGQRHSNGTKKH---------------------TFKPETYEA---CIQYIGDG- 551
            |.:..|........:|.|.|:.:                     ||..:..|.   |...:.|.
Yeast   422 QSSNDNPNEPELESQHPNETEANKLDSLPPAANNPTGTLSSDELTFTHDLIEKVFNCNDKLSDNY 486

  Fly   552 -------------TSALPSFPPIE---LNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFN 600
                         ||....||.|.   |....:|::    :.:...||..||.|..:.:..|:.:
Yeast   487 NTQILSNTEHPLLTSYKLDFPKIPAGVLPTDTDSDV----ISSLESLYHIHCNSVYECIKFLKSD 547

  Fly   601 TVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVL 665
            .:...|  |:  |::|::.......::|:..:          .:|.:.|...|...:......::
Yeast   548 NISNAL--FF--SNSNSISPTMFNLFISEPLI----------DWVTKCDLITYTGLIKFFSQFII 598

  Fly   666 RS--IPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSL 719
            .|  |.:::.|.:.:..|.|...:.:::|.:|:.|.|.|.|.::.|.:.:::...|
Yeast   599 HSNEISDSIIQKLESMIKLLPEQINKAVLELPKALVQRKLSIINNFTKLVKKLIKL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	393..466	CDD:280427	33/72 (46%)
RFX1	NP_013277.1	RFX_DNA_binding	282..358	CDD:396712	33/75 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000699
OrthoInspector	1	1.000	-	-		otm46895
orthoMCL	1	0.900	-	-		OOG6_102578
Panther	1	1.100	-	-	LDO	PTHR12619
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1282
SonicParanoid	1	1.000	-	-		X291
TreeFam	0	0.000	Not matched by this tool.
	8	8.030