DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rfx and rfx3

DIOPT Version :9

Sequence 1:	NP_001247023.2	Gene:	Rfx / 41266	FlyBaseID:	FBgn0020379	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	XP_012820253.1	Gene:	rfx3 / 779608	XenbaseID:	XB-GENE-1021689	Length:	809	Species:	Xenopus tropicalis

Alignment Length:	849	Identity:	350/849 - (41%)
Similarity:	455/849 - (53%)	Gaps:	220/849 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 TMGTITTTEPNGTTVTHSIPIHSMADLAAIKDGVDLAQQV-ANGQVTVVQTTEDDDGTPFITVTV 211
            ||.|..|....|:|||...   |:|..||:.  ..:.||| ...||..|||.:
Frog    52 TMQTSETVSDTGSTVTLQT---SVAGQAAVP--TQVVQQVPVQQQVQQVQTVQ------------ 99

  Fly   212 SGQEQNY---QVQYVD-SELYHSNSSQTQMTYPFCPVGDYQGNGQTAYYSTTG------------ 260
              |.|:.   |||||: |:..::|.:....|||:.....|..|....|:.|.|
Frog   100 --QVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGGSAQVTTVVSTH 162

  Fly   261 --------QYGTT-----SSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSP 312
                    |.|.|     ||.||:          ||:    |..:..|.||:|.:.     |.||
Frog   163 SMVGTGGIQMGVTGGQIISSTGGT----------YLI----GNAMENSGHSVSHTT-----RASP 208

  Fly   313 HSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPD 377
            .::.::....::.    :|.:.|
Frog   209 ATIEMAIETLQKS----DGLSSH------------------------------------------ 227

  Fly   378 SDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSV 442
              :|:|.:|:      ::||..|||||:|||||||||||||::||.||||:|||||||||||||:
Frog   228 --RSSLLNSH------LQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSI 284

  Fly   443 FSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSD-------------GT 494
            |.|||||||||||||||||||||:||.|.|| :..:|.|.:|....|...             |.
Frog   285 FMGLRTRRLGTRGNSKYHYYGIRVKPDSPLN-RLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVGD 348

  Fly   495 GGPGSGPM-VSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSF 558
            |..|||.. .||..:...|           .|.|.                 |:: |.:.|||.|
Frog   349 GFAGSGQSGASVEQTVIAQ-----------SQHHQ-----------------QFL-DASRALPEF 384

  Fly   559 PPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRAS---------- 613
            ..:|:: |.....|.||:.:.:.|||||||:.||.|:||:|:.:|.|.:.|||.|
Frog   385 AEVEIS-SLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSSPADGSTI 448

  Fly   614 -DNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIR 677
             ::.||.|.|..  |.|:||.|.|....:.|::...|:..||:.|:::||||||.||:|||||:|
Frog   449 TESGNLSEIESR--LPKSKLILFCKNESIVKWMCNCDHMMYQSLVEILIPDVLRPIPSALTQAVR 511

  Fly   678 NFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSD 742
            ||||:||.||..:|..:|:::.|.|.:|||||.||||||||||||||||||||||.:||:|||:|
Frog   512 NFAKSLEGWLSSAMSNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLND 576

  Fly   743 LNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTY 807
            ||||||.||||||:||.||..::|||||:|||..|||||:|||||:||..||..|::.|.|:|::
Frog   577 LNRVDFANVQEQASWVCQCDDSMVQRLETDFKMTLQQQSTLEQWAAWLDNVVTQALKPYEGRPSF 641

  Fly   808 ARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVIC 872
            .:|||||||||||||||:|||||||||:|||||||||||:||||||||||::|:|..::.|||:.
Frog   642 PKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGESPIAVMG 706

  Fly   873 E----------RMKKDMDFEFECQFAYITSDTEHQTTPSSASSGGDVGNE------------AKR 915
            |          .|:| :.:.|.|                 |..|.||.:|            |||
Frog   707 EFGDLNDASPGNMEK-VSWLFVC-----------------ADEGSDVESEIEEELDDSVEPPAKR 753

  Fly   916 LKQE 919
            .|.|
Frog   754 EKTE 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	393..466	CDD:280427	60/72 (83%)
rfx3	XP_012820253.1	RFX1_trans_act	<103..189	CDD:282451	23/95 (24%)
rfx3	XP_012820253.1	RFX_DNA_binding	236..308	CDD:280427	60/71 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I786
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7917
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1199
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278246at33208
OrthoFinder	1	1.000	-	-		FOG0000699
OrthoInspector	1	1.000	-	-		otm49147
Panther	1	1.100	-	-	LDO	PTHR12619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1282
SonicParanoid	1	1.000	-	-		X291
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.100