Protein Alignment Rfx and RFX8

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: XP_016860340.1
• Gene: RFX8 / 731220
• HGNCID: 37253
• Length: 586
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 136/552 - (24%)
• Similarity: 227/552 - (41%)
• Gaps: 136/552 - (24%)

  Fly   371 GGGASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASF 435
            |..|||.|.:.:.|..    |..|:||..|:...:..|:||..:|..|::.|.::....||.|:|
Human     4 GVPASPSSGEGSRGPH----SGVIQWLVDNFCICEECSVPRCLMYEIYVETCGQNTENQVNPATF 64

  Fly   436 GKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQ---AMDDKQMLAAGYGPSSDGTGGP 497
            |||:|.||..|.||||||||:::|||.||.||..|...:|   .:.:|:.
Human    65 GKLVRLVFPDLGTRRLGTRGSARYHYDGICIKKSSFFYAQYCYLIGEKRY--------------- 114

  Fly   498 GSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQY--------------I 548
            .||..::...||                              .|.:.||.              :
Human   115 HSGDAIAFEKST------------------------------NYNSIIQQEATCEDHSPMKTDPV 149

  Fly   549 GDGTSALPSFPPIE----LNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDF 609
            |...|.....|.:|    ..:|.|....|.|         |:|....|.:.|     ||.||..|
Human   150 GSPLSEFRRCPFLEQEQAKKYSCNMMAFLAD---------EYCNYCRDILRN-----VEDLLTSF 200

  Fly   610 WRASDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQ 674
            |::...:.:               :|....:|.:..:..|.|.|:...||::.|.|..:.....:
Human   201 WKSLQQDTV---------------MLMSLPDVCQLFKCYDVQLYKGIEDVLLHDFLEDVSIQYLK 250

  Fly   675 AIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQM 739
            :::.|:|..::||..::.|||..|...|...|:.|.:.|||.|.|:::|:..|.||::..::|.:
Human   251 SVQLFSKKFKLWLLNALEGVPALLQISKLKEVTLFVKRLRRKTYLSNMAKTMRMVLKSKRRVSVL 315

  Fly   740 LSDLNRVDFHNVQEQAAWVSQCAPAVVQR-LESDFKAALQQQSSLEQ------------------ 785
            .|||..:           ::|...|..:: |.||...|.:.:::.|.
Human   316 KSDLQAI-----------INQGTLATSKKALASDRSGADELENNPEMKCLRNLISLLGTSTDLRV 369

  Fly   786 ----WASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLL 846
                .:|.||..|   .:....|..:.:.|..|.|:|:...:.:.:.:||....||||:||..||
Human   370 FLSCLSSHLQAFV---FQTSRSKEEFTKLAASFQLRWNLLLTAVSKAMTLCHRDSFGSWHLFHLL 431

  Fly   847 FDEYMFYLVEHKIAEAQDKTAIAVICERMKKD 878
            ..|||.::::..:.|.:::..:..:.|.:..|
Human   432 LLEYMIHILQSCLEEEEEEEDMGTVKEMLPDD 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	35/75 (47%)
RFX8	XP_016860340.1	RFX_DNA_binding	23..97	CDD:460512	35/73 (48%)