Protein Alignment Rfx and Rfx8

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: NP_001139132.1
• Gene: Rfx8 / 619289
• MGIID: 3588206
• Length: 596
• Species: Mus musculus
• Alignment Length: 563
• Identity: 144/563 - (25%)
• Similarity: 235/563 - (41%)
• Gaps: 123/563 - (21%)

  Fly   374 ASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKL 438
            |.|.|..|.||....|    |:||..|:...:|.|:||..:|..|::.|.:.....||.|:||||
Mouse     4 AVPASPASGLGLHRGI----IQWLVDNFCICEGFSVPRCLMYEIYVETCGQSAQNQVNPATFGKL 64

  Fly   439 IRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGS--------LLNSQAMDDKQMLAAGYGPSSDGTG 495
            :|.||..|.||||||||:::|||.||.||..|        ||..::.....::|.|..|.
Mouse    65 VRLVFPDLGTRRLGTRGSARYHYDGIYIKKSSFFYAHYCYLLGKKSCHSGNLIAFGKFPD----- 124

  Fly   496 GPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQY--IGDGTSALPSF 558
                                           :||..::.       |.|..:  |.......|..
Mouse   125 -------------------------------YSNVLQQE-------ETCENHSPIKKDPMGSPVS 151

  Fly   559 P----PI---ELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNN 616
            |    |:   ||.:.::.:|.:...|.    |..:|...|..|.|.|...||.|:..||::...:
Mouse   152 PFRRCPVWEQELANKYSCKLVVFLADE----YCNYCRDILQNVRNQELEKVEDLITSFWKSRQQD 212

  Fly   617 NLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAK 681
            .:               :|....:|::.:...|.|.|:...|:::||.|..:.....:::|.|:|
Mouse   213 TV---------------MLMSLPDVRQLLGCYDMQLYKGLEDMLLPDFLEDVSIQYLKSVRLFSK 262

  Fly   682 NLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRV 746
            ..::||..::.|.|..|...|...|:.|.:.|||.|.|:::|:..:.||:|..:|..:.|||..:
Mouse   263 RFKLWLLGALEGFPAILQISKLKEVTGFVKRLRRKTYLSNMAKTMKMVLKNSRRIGLLKSDLRAI 327

  Fly   747 ----------------DFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVE 795
                            ..|..:.::....:|...::..||:....|    ..|...:|.||::|
Mouse   328 IREGTLDISKKVLEGDSDHEEEPESHTEMKCLGCLISLLETSTDLA----ELLNCVSSNLQVLV- 387

  Fly   796 SAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIA 860
              .:....|..:.:.|..|.|||:|..:.:.:.:||....|||::||..||..||:.:::|..|.
Mouse   388 --FQPSKNKEDFIKLAASFQLKWNFLLTAVSKAMTLSHRDSFGAWHLFHLLLLEYVIHILESCIE 450

  Fly   861 EAQDKTAIAVICERMKKDMDFEFECQFAYITSDTEHQTTPSSA 903
            |.::        |.:....|         :.||.:..|.|..|
Mouse   451 EEEE--------EDLGSLQD---------LLSDDQFLTQPDQA 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	36/75 (48%)
Rfx8	NP_001139132.1	RFX_DNA_binding	19..94	CDD:460512	37/78 (47%)