DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rfx and RFX3

DIOPT Version :9

Sequence 1:	NP_001247023.2	Gene:	Rfx / 41266	FlyBaseID:	FBgn0020379	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	XP_024303398.1	Gene:	RFX3 / 5991	HGNCID:	9984	Length:	800	Species:	Homo sapiens

Alignment Length:	861	Identity:	351/861 - (40%)
Similarity:	452/861 - (52%)	Gaps:	232/861 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 MGTITTTEPNGTTVTHSIPIHSMADLAAIKDGVDLAQQV-ANGQVTVVQTTEDDDGTPFITVTVS 212
            |.|..|....|:|||...   |:|..||:.  ..:.||| ...||..|||.:
Human    31 MQTSETGSDTGSTVTLQT---SVASQAAVP--TQVVQQVPVQQQVQQVQTVQ------------- 77

  Fly   213 GQEQNY---QVQYVD-SELYHSNSSQTQMTYPFCPVGDYQGNGQTAYYSTTG------------- 260
             |.|:.   |||||: |:..::|.:....|||:.....|..|....|:.|.|
Human    78 -QVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHS 141

  Fly   261 -------QYGTT-----SSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPH 313
                   |.|.|     ||:||:          ||:    |..:..|.||::.:.     |.||
Human   142 MVGTGGIQMGVTGGQLISSSGGT----------YLI----GNSMENSGHSVTHTT-----RASP- 186

  Fly   314 SLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDS 378
                                       |.|:.|..|.| .:...:||.:|
Human   187 ---------------------------ATIEMAIETLQ-KSDGLSTHRSS--------------- 208

  Fly   379 DQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVF 443
                      :.::.::||..|||||:|||||||||||||::||.||||:|||||||||||||:|
Human   209 ----------LLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIF 263

  Fly   444 SGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPS---------------SDG 493
            .|||||||||||||||||||||:||.|.|| :..:|.|.:|....|.               :||
Human   264 MGLRTRRLGTRGNSKYHYYGIRVKPDSPLN-RLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADG 327

  Fly   494 TGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSF 558
            ..|.|.....||..:...|           .|.|.                 |:: |.:.|||.|
Human   328 FTGSGQQTGTSVEQTVIAQ-----------SQHHQ-----------------QFL-DASRALPEF 363

  Fly   559 PPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRAS---------- 613
            ..:|:: |.....|.||:.:.:.|||||||:.||.|:||:|:.:|.|.:.|||.|
Human   364 GEVEIS-SLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTI 427

  Fly   614 -DNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIR 677
             :::||.|.|..  |.|.||..||....:.|::...|:..||..|:::||||||.||:|||||||
Human   428 TESSNLSEIESR--LPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIR 490

  Fly   678 NFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSD 742
            ||||:||.||..:|..:|:::.|.|.:|||||.||||||||||||||||||||||.:||:|||||
Human   491 NFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSD 555

  Fly   743 LNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTY 807
            ||||||.||||||:||.||...:|||||:|||..|||||:|||||:||..|:..|::.|.|:|::
Human   556 LNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSF 620

  Fly   808 ARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVIC 872
            .:|||||||||||||||:|||||||||:|||||||||||:||||||||||::|:|..:|.|||:.
Human   621 PKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMG 685

  Fly   873 ERMKKDMDFEFECQFAYITSDTEHQTTP---------------SSASSGG---DVGNE------- 912
            |                 |:..:.:.||               ::.|.|.   |.|:|
Human   686 E-----------------TNLVDEKNTPIMELFISKLLNFGDLNAVSPGNLDKDEGSEVESEMDE 733

  Fly   913 ---------AKRLKQE 919
                     |||.|.|
Human   734 ELDDSSEPQAKREKTE 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	393..466	CDD:280427	60/72 (83%)
RFX3	XP_024303398.1	RFX1_trans_act	<81..167	CDD:309643	23/95 (24%)
RFX3	XP_024303398.1	RFX_DNA_binding	214..286	CDD:308073	60/71 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159861
Domainoid	1	1.000	386	1.000	Domainoid score	I808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7917
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278246at33208
OrthoFinder	1	1.000	-	-		FOG0000699
OrthoInspector	1	1.000	-	-		otm41924
orthoMCL	1	0.900	-	-		OOG6_102578
Panther	1	1.100	-	-	LDO	PTHR12619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1282
SonicParanoid	1	1.000	-	-		X291
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.930