DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rfx and RFX2

DIOPT Version :10

Sequence 1:NP_001247023.2 Gene:Rfx / 41266 FlyBaseID:FBgn0020379 Length:919 Species:Drosophila melanogaster
Sequence 2:NP_000626.2 Gene:RFX2 / 5990 HGNCID:9983 Length:723 Species:Homo sapiens


Alignment Length:689 Identity:312/689 - (45%)
Similarity:402/689 - (58%) Gaps:122/689 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   219 QVQYVD--SELYHSNSSQTQMTYPFCPVGDYQGNGQTAYYSTTG------------------QYG 263
            |||||:  ..:|.:.:.:|..||...| ..|..:...:|:...|                  ..|
Human    71 QVQYVEGGDAVYTNGAIRTAYTYNPEP-QMYAPSSTASYFEAPGGAQVTVAASSPPAVPSHSMVG 134

  Fly   264 TTSSAGG----SSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPHSLTVSSRDWER 324
            .|...||    ||.||      ||  :..|  ::.:.|||:.:     .|.||.:|.::      
Human   135 ITMDVGGSPIVSSAGA------YL--IHGG--MDSTRHSLAHT-----SRSSPATLEMA------ 178

  Fly   325 DADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQSALGSSNKI 389
                           :..:|:::.        .|:|.:.                         :
Human   179 ---------------IENLQKSEG--------ITSHKSG-------------------------L 195

  Fly   390 ASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTR 454
            .::.::||..|||||:|||||||:|||||::||.||||:|||||||||||||||.||||||||||
Human   196 LNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLDPVNAASFGKLIRSVFMGLRTRRLGTR 260

  Fly   455 GNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSNGL 519
            |||||||||||:||.|.|| :..:|.|.:|.            ...||.........|.|.|.|.
Human   261 GNSKYHYYGIRLKPDSPLN-RLQEDTQYMAM------------RQQPMHQKPRYRPAQKTDSLGD 312

  Fly   520 GGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSF--NSELTLEDVDTFRGL 582
            .|.|...||...:....:.:.::   ||| |.:...|.||..:|. ||  ...:||.||...:.:
Human   313 SGSHSGLHSTPEQTMAVQSQHHQ---QYI-DVSHVFPEFPAPDLG-SFLLQDGVTLHDVKALQLV 372

  Fly   583 YREHCESFLDAVLNLEFNTVEFLLRDFW--RASDNNN------LDECEEEKYLSKTKLYLLCHCA 639
            ||.|||:.:|.|:||:|:.:|.|...||  :||.::.      .||..|...|.|.||..||.|.
Human   373 YRRHCEATVDVVMNLQFHYIEKLWLSFWNSKASSSDGPTSLPASDEDPEGAVLPKDKLISLCQCD 437

  Fly   640 EVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTS 704
            .:.:::|..|:..||..|:::||||||.:|:.||||||||||:||.||..:|...|:|:.|.|..
Human   438 PILRWMRSCDHILYQALVEILIPDVLRPVPSTLTQAIRNFAKSLEGWLTNAMSDFPQQVIQTKVG 502

  Fly   705 AVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRL 769
            .||||.||||||||||||||||||||||.:||:|||||||||||.||||||:||.||..:|||||
Human   503 VVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESVVQRL 567

  Fly   770 ESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSA 834
            |.|||..|||||||:||||||..||...::::.|.|::.:|||||||||||||||:|||||||||
Human   568 EQDFKLTLQQQSSLDQWASWLDSVVTQVLKQHAGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSA 632

  Fly   835 SSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICE 873
            :|||||||||||:||||||||||::|||..:|.|||:.|
Human   633 ASFGSFHLIRLLYDEYMFYLVEHRVAEATGETPIAVMGE 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RfxNP_001247023.2 RFX_DNA_binding 392..468 CDD:460512 61/75 (81%)
RFX2NP_000626.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
RFX1_trans_act 4..154 CDD:461362 23/91 (25%)
RFX_DNA_binding 200..274 CDD:460512 61/73 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 292..332 10/39 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 688..723
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.