Protein Alignment Rfx and RFX1

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: XP_011526468.1
• Gene: RFX1 / 5989
• HGNCID: 9982
• Length: 1089
• Species: Homo sapiens
• Alignment Length: 1066
• Identity: 369/1066 - (34%)
• Similarity: 479/1066 - (44%)
• Gaps: 286/1066 - (26%)

  Fly     2 TTRLAPQRQFILSTRSAIVDATSP----------------------PEDSAEEQQQLTVEV-ESA 43
            |....||.|::...:|....|..|                      |..|...||.:.|.| |.|
Human    45 TAAATPQPQYVTELQSPQPQAQPPGGQKQYVTELPAVPAPSQPTGAPTPSPAPQQYIVVTVSEGA 109

  Fly    44 TNGVITNSTTSPPPHAEQFEFCTEDGVVVSATLEDVMTQVK-------LFPL-LQNCQLLQKKLV 100
            .....|.|..||...|.|....|:....|..|.:.::.|..       :.|| |.|.|:.|:.|
Human   110 MRASETVSEASPGSTASQTGVPTQVVQQVQGTQQRLLVQTSVQAKPGHVSPLQLTNIQVPQQAL- 173

  Fly   101 DEDDDSTGVGATDADQLEVISVVLPMDAEDSTSDAHLHG-------------HVVNSSSDTMGTI 152
                         ..|..|:....| .::.......:||             ...:|||.|.|..
Human   174 -------------PTQRLVVQSAAP-GSKGGQVSLTVHGTQQVHSPPEQSPVQANSSSSKTAGAP 224

  Fly   153 TTTEPNGTT---VTHSIPIHS-----MADLAAIKDG------------VDLAQQVANGQVTVVQT 197
            |.|.|....   |..|:|:..     .|...|.|.|            |.:||:.:..|....:.
Human   225 TGTVPQQLQVHGVQQSVPVTQERSVVQATPQAPKPGPVQPLTVQGLQPVHVAQESSGSQFPARKA 289

  Fly   198 TEDDD------------------------------------------------------------ 202
            .:.|.
Human   290 EQRDPRPTPPPEPPPRPPACSGEAPQLGSPEPPPPHYEPGAEQWVELVGVLPPHLLLPQQKVVFE 354

  Fly   203 --------------------------GTPFITVTVSGQEQ-------NYQVQYV---DSELYHSN 231
                                      ||....:.|...:|       :.|||||   |:....|.
Human   355 PLSRLPARASPDQRVRIQRIPQVLVFGTAATALKVQQLQQVPVPHVYSSQVQYVEGGDASYTASA 419

  Fly   232 SSQTQMTYPFCPVGDYQGNGQTAYYSTTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEGILLNGSA 296
            ...:..:||..|:  |.....|:||...|.....|:...|...|.|.::|..|   .|..:..|:
Human   420 IRSSTYSYPETPL--YTQTASTSYYEAAGTATQVSTPATSQAVASSGSMPMYV---SGSQVVASS 479

  Fly   297 HSLSQSQSQSHGRDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHS 361
            .|.....|.|.|                                                   ..
Human   480 TSTGAGASNSSG---------------------------------------------------GG 493

  Fly   362 ASGGSLGTGGGGASPDSDQSA----------------LGSSN-------KIASATIKWLSRNYET 403
            .|||..|.||||....|..:.                |||::       :.:.||::||..||||
Human   494 GSGGGGGGGGGGGGGGSGSTGGGGSGAGTYVIQGGYMLGSASQSYSHTTRASPATVQWLLDNYET 558

  Fly   404 ADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKP 468
            |:||||||||||.||:.||.|.||||||||||||||||||.|||||||||||||||||||:|||.
Human   559 AEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKA 623

  Fly   469 GSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKK 533
            .|.| .:.|:|:|.:|....|.|..........|..:|:..|            .||:.|.|...
Human   624 SSPL-LRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGMTNGVA------------VGQQPSTGLSD 675

  Fly   534 HTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSE-LTLEDVDTFRGLYREHCESFLDAVLNL 597
            .:.:.:.|:   |:: |.:.:||.|..::|......| :...|:..|:.|||||||:.:|.::||
Human   676 ISAQVQQYQ---QFL-DASRSLPDFTELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNL 736

  Fly   598 EFNTVEFLLRDFWRASDNNNLDECEE----------EKYLSKTKLYLLCHCAEVQKFVREVDYQF 652
            :|..||.|.:.|||    .||.:..|          ||.|.|..|.||.....|.::.:..|...
Human   737 QFTLVETLWKTFWR----YNLSQPSEAPPLAVHDEAEKRLPKAILVLLSKFEPVLQWTKHCDNVL 797

  Fly   653 YQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYT 717
            ||..|:::||||||.||:|||||||||||:||.||..:|:.:||::.::|.:|..||.|||||||
Human   798 YQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYT 862

  Fly   718 SLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSS 782
            |||||||||||||||.|||:|||||||||||.||||||:||.:|...||||||.|||..||||:|
Human   863 SLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNS 927

  Fly   783 LEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLF 847
            |||||:||..||...::.|.|...:.:||:.|||||||||||:|||||||||:|||||||||||:
Human   928 LEQWAAWLDGVVSQVLKPYQGSAGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLY 992

  Fly   848 DEYMFYLVEHKIAEAQDKTAIAVICE 873
            ||||:||:||::|:|:.:|.|||:.|
Human   993 DEYMYYLIEHRVAQAKGETPIAVMGE 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	63/75 (84%)
RFX1	XP_011526468.1	Atrophin-1	58..>265	CDD:460830	48/221 (22%)
		RFX1_trans_act	216..482	CDD:461362	47/270 (17%)
		RFX_DNA_binding	546..623	CDD:460512	63/76 (83%)