Protein Alignment Rfx and Rfx3

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: XP_038940262.1
• Gene: Rfx3 / 361746
• RGDID: 1307779
• Length: 780
• Species: Rattus norvegicus
• Alignment Length: 873
• Identity: 356/873 - (40%)
• Similarity: 460/873 - (52%)
• Gaps: 212/873 - (24%)

  Fly   113 DADQLEVISVVLPMDAEDSTSDAHLHGHVVNSSSDTMGTITTTEPNGTTVTHSIPIHSMADLAAI 177
            :|.|||.       |......|.:|.....:.|...|.|..|....|:|||...   |:|..||:
  Rat     3 EASQLET-------DFYQRNVDWNLQWFSKSQSETIMQTSETGSDTGSTVTLQT---SVASQAAV 57

  Fly   178 KDGVDLAQQV-ANGQVTVVQTTEDDDGTPFITVTVSGQEQNY---QVQYVD-SELYHSNSSQTQM 237
            .  ..:.||| ...||..|||.:              |.|:.   |||||: |:..::|.:....
  Rat    58 P--TQVVQQVPVQQQVQQVQTVQ--------------QVQHVYPAQVQYVEGSDTVYTNGAIRTT 106

  Fly   238 TYPFCPVGDYQGNGQTAYYSTTG--------------------QYGTT-----SSAGGSSNGAHS 277
            |||:.....|..|....|:.|.|                    |.|.|     ||:||:
  Rat   107 TYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGT------ 165

  Fly   278 TTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAY 342
                ||:    |..:..|.||::.:.     |.||                            |.
  Rat   166 ----YLI----GNSMENSGHSVTHTT-----RASP----------------------------AT 189

  Fly   343 IQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQSALGSSNKIASATIKWLSRNYETADGV 407
            |:.|..|.| .:...:||.:|                         :.::.::||..|||||:||
  Rat   190 IEMAIETLQ-KSDGLSTHRSS-------------------------LLNSHLQWLLDNYETAEGV 228

  Fly   408 SLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLL 472
            |||||||||||::||.||||:|||||||||||||:|.|||||||||||||||||||||:||.|.|
  Rat   229 SLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPL 293

  Fly   473 NSQAMDDKQMLAAGYGPS---------------SDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGG 522
            | :..:|.|.:|....|.               :||..|.|.....||..:...|
  Rat   294 N-RLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQ---------- 347

  Fly   523 HGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSELTLEDVDTFRGLYREHC 587
             .|.|.                 |:: |.:.|||.|..:|:: |.....|.||:.:.:.||||||
  Rat   348 -SQHHQ-----------------QFL-DASRALPEFGEVEIS-SLPDGTTFEDIKSLQSLYREHC 392

  Fly   588 ESFLDAVLNLEFNTVEFLLRDFWRAS-----------DNNNLDECEEEKYLSKTKLYLLCHCAEV 641
            |:.||.|:||:|:.:|.|.:.|||.|           :::||.|.|..  |.|.||..||....:
  Rat   393 EAILDVVVNLQFSLIEKLWQTFWRYSPSTPTDGTTITESSNLSEIESR--LPKAKLITLCKHESI 455

  Fly   642 QKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAV 706
            .|::...|:..||..|:::||||||.||:|||||||||||:||.||..:|..:|:::.|.|.:||
  Rat   456 LKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAV 520

  Fly   707 SAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLES 771
            |||.||||||||||||||||||||||.:||:|||||||||||.||||||:||.||...:|||||:
  Rat   521 SAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLET 585

  Fly   772 DFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASS 836
            |||..|||||:|||||:||..|:..|::.|.|:|::.:|||||||||||||||:|||||||||:|
  Rat   586 DFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAAS 650

  Fly   837 FGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICE----------RMKKDMDFEFECQFAYIT 891
            ||||||||||:||||||||||::|:...:|.|||:.|          .:.||...|.|.:   :.
  Rat   651 FGSFHLIRLLYDEYMFYLVEHRVAQVTGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESE---MD 712

  Fly   892 SDTEHQTTPSSASSGGDVGNEAKRLKQE 919
            .|.:..:.|           :|||.|.|
  Rat   713 EDLDDSSEP-----------QAKREKTE 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	61/75 (81%)
Rfx3	XP_038940262.1	RFX1_trans_act	<82..169	CDD:461362	24/100 (24%)
		RFX_DNA_binding	215..289	CDD:460512	61/73 (84%)