Protein Alignment Rfx and Rfx6

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: NP_001152861.1
• Gene: Rfx6 / 320995
• MGIID: 2445208
• Length: 927
• Species: Mus musculus
• Alignment Length: 650
• Identity: 187/650 - (28%)
• Similarity: 275/650 - (42%)
• Gaps: 172/650 - (26%)

  Fly   339 EVAYIQEAQSTPQTPT--------------------------STTTTHSASGGSLG--------- 368
            |.|::|| |.:||.|:                          :.|...:.|.|..|
Mouse     8 EEAFVQE-QPSPQLPSEIAEECCAQLLGKGLLVYPEDSAYLLAETAAGARSSGEKGGDPGLQVGV 71

  Fly   369 ------TGGGGASPDSDQSALGSSNKIA---------------------SATIKWLSRNYETADG 406
                  ..|..:|.:.|.....|..|.|                     ..|::||..||...:|
Mouse    72 KSEMQLNNGNFSSEEEDADTQESKTKAADPQLSQKKSITQMMKDKKKQTQLTLQWLEDNYIVCEG 136

  Fly   407 VSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSL 471
            |.|||..||.||:..|.:.||||..||:|||.||..|..|.||||||||:||||||||.||..|
Mouse   137 VCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESS- 200

  Fly   472 LNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTF 536
                         |.|.....|.|         :|..:..:|...    ||..:::|..:|..|.
Mouse   201 -------------AYYHSVYSGKG---------LTRFSGSKLKNE----GGFTRKYSLSSKTGTL 239

  Fly   537 KPE-------TYEACIQYIGDGTSALPSFPPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAV 594
            .||       .|:.||                          :.:.|||...:|:.||:..||..
Mouse   240 LPEFPSAQHLVYQGCI--------------------------SKDKVDTLIMMYKTHCQCILDNA 278

  Fly   595 LNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDV 659
            :|..|..::..|..||:...::.|...|....:.     :.|.|          |...|:...||
Mouse   279 INGNFEEIQHFLLHFWQGMPDHLLPLLENPVIID-----IFCVC----------DSILYKVLTDV 328

  Fly   660 IIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQ 724
            :||..::.:|.:|...|||||||.|.|:..|:..:||.|...|...:..|..:|:|.||..||||
Mouse   329 LIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALIDKKIPILRRFVSSLKRQTSFLHLAQ 393

  Fly   725 AARAVLQNGAQISQMLSDLNRVDFHNVQEQA-AWVSQCAPAVVQRLESD-------------FKA 775
            .||..|.:...::.|:||:.:||.:::..|| ..:|.....     |||             .|.
Mouse   394 IARPALFDQHVVNAMVSDIEKVDLNSIGSQALLTISNSTDT-----ESDIYSEHDSITVFQELKD 453

  Fly   776 ALQQQSSLEQWASWLQLVVES---AMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSF 837
            .|::.:::|.:..||..|||.   .|.:.||: :..:.|:.|||||||:.:.::.:|||.:||||
Mouse   454 LLKKNATVEAFIEWLDTVVEQRVIKMSKQNGR-SLKKRAQDFLLKWSFFGARVMHNLTLNNASSF 517

  Fly   838 GSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICERMKKDMDFEFECQFAYITSDTEHQTTPSS 902
            |||||||:|.|||:...:|.:....::: .:..:.::..|:.|          .|......:|||
Mouse   518 GSFHLIRMLLDEYILLAMETQFNNDKEQ-ELQNLLDKYMKNSD----------ASKAAFTASPSS 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	45/75 (60%)
Rfx6	NP_001152861.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		7/13 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..108		5/26 (19%)
		RFX_DNA_binding	123..198	CDD:460512	45/74 (61%)