Protein Alignment Rfx and Rfx2

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: XP_038939066.1
• Gene: Rfx2 / 301121
• RGDID: 1588579
• Length: 784
• Species: Rattus norvegicus
• Alignment Length: 700
• Identity: 321/700 - (45%)
• Similarity: 406/700 - (57%)
• Gaps: 103/700 - (14%)

  Fly   203 GTPFITVT------VSGQEQNY---QVQYVD--SELYHSNSSQTQMTYPFCPVGDYQGNGQTAYY 256
            |||..|:|      |..|.|:.   |||||:  ..:|.:.:.:...||...| ..|..:...:|:
  Rat   108 GTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYTYNPDP-QLYAPSSAASYF 171

  Fly   257 STTGQYGTTSSAGG----SSNGAHSTTLPYL-VPVEEG---ILLNGSAHSLSQSQSQSHGRDSP- 312
            .|.|....|.:|..    .|:|....|:... .|:..|   .|::|             |.||.
  Rat   172 ETPGGAQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGTYLIHG-------------GMDSTR 223

  Fly   313 HSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPD 377
            |||.                           ..|:|:|.|......|...|.|.....||
  Rat   224 HSLA---------------------------HTARSSPATLEMAIETLQKSEGLAPHKGG----- 256

  Fly   378 SDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSV 442
                       :.::.::||..|||||:|||||||:|||||::||.|||||||||||||||||||
  Rat   257 -----------LLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSV 310

  Fly   443 FSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTS 507
            |.|||||||||||||||||||||:||.|.|| :..:|.|.:|....|:..   .|...|
  Rat   311 FMGLRTRRLGTRGNSKYHYYGIRLKPDSPLN-RLQEDTQYMAMRQQPTHQ---KPRYRP------ 365

  Fly   508 STAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSE-L 571
               .|.:.|.|.|..|...||...:....:.:.::   ||| |.:...|.||..:|..:...| :
  Rat   366 ---AQKSDSLGDGSAHSNMHSTPEQAMAAQGQHHQ---QYI-DVSHVFPEFPAPDLGSTLLQESV 423

  Fly   572 TLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNN--------LDECEEEKYLS 628
            ||.||...:.:||.|||:.||.|:||:|..:|.|...||.....::        .||..|...|.
  Rat   424 TLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDGRASLPASDEEPEVTLLP 488

  Fly   629 KTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLG 693
            |.||..||.|..:.:::|..|:..||..|:.:||||||.:|::||||||||||:||.||..:|.|
  Rat   489 KDKLISLCKCEPILQWMRSCDHILYQALVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSG 553

  Fly   694 VPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWV 758
            .|:|:.|.|...||||.||||||||||||||||||||||.:||:|||||||||||.||||||:||
  Rat   554 FPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWV 618

  Fly   759 SQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSS 823
            .||..::|||||.|||..|||||||:||||||..||...::::.|.|::.:||||||||||||||
  Rat   619 CQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHAGSPSFPKAARQFLLKWSFYSS 683

  Fly   824 MIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICE 873
            |:|||||||||:|||||||||||:||||||||||::|:|..:|.|||:.|
  Rat   684 MVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGE 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	62/75 (83%)
Rfx2	XP_038939066.1	RFX1_trans_act	91..216	CDD:461362	29/108 (27%)
		RFX_DNA_binding	262..336	CDD:460512	62/73 (85%)