DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rfx and Rfx6

DIOPT Version :9

Sequence 1:	NP_001247023.2	Gene:	Rfx / 41266	FlyBaseID:	FBgn0020379	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	XP_006256506.2	Gene:	Rfx6 / 294395	RGDID:	1307491	Length:	853	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	172/548 - (31%)
Similarity:	258/548 - (47%)	Gaps:	95/548 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 KIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLG 452
            |....|::||..||...:||.|||..||.||:..|.:.||||..||:|||.||..|..|.|||||
  Rat    44 KQTQLTLQWLEDNYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLG 108

  Fly   453 TRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSN 517
            |||:||||||||.||..|              |.|.....|.|         :|..:..:|....
  Rat   109 TRGHSKYHYYGIGIKESS--------------AYYHSVYSGKG---------LTRFSGSKLKNEG 150

  Fly   518 GLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSELTLEDVDTFRGL 582
            |.           |:|::...:|          || .||.||..: :..:...:..:.|||...:
  Rat   151 GF-----------TRKYSLSSKT----------GT-LLPEFPSAQ-HLVYPGCIAKDKVDTLIMM 192

  Fly   583 YREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVRE 647
            |:.||:..||..:|..|..::..|..||:...::.|...|....:.     :.|.|
  Rat   193 YKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIID-----IFCVC--------- 243

  Fly   648 VDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQT 712
             |...|:...||:||..::.:|.:|...|||||||.|.|:..|:..:||.|...|...:..|..:
  Rat   244 -DSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALIDKKIPILRRFVSS 307

  Fly   713 LRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDF---- 773
            |:|.||..||||.||..|.:...::.|:||:.:||.:::..||......:......:.|::
  Rat   308 LKRQTSFLHLAQIARPALFDQHVVNAMVSDIEKVDLNSIGSQALLTISNSTDTESDIYSEYDSIT 372

  Fly   774 -----KAALQQQSSLEQWASWLQLVVES---AMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLT 830
                 |..|::.:::|.:..||..|||.   .|.:.||: :..:.|:.|||||||:.:.::.:||
  Rat   373 VFQELKDLLKKNATVEAFIEWLDTVVEQRVIKMSKQNGR-SLKKRAQDFLLKWSFFGARVMHNLT 436

  Fly   831 LRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICERMKKDMDFEFECQFAYITSDTE 895
            |.:||||||.||||:|.|||:...:|.:....:::....::.:.||..     |...|..|:
  Rat   437 LNNASSFGSLHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNS-----EASKAAFTA--- 493

  Fly   896 HQTTPS----------SASSGGDVGNEA 913
               :||          |:.|...|.||:
  Rat   494 ---SPSSCFLANRNKGSSLSSDPVKNES 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	393..466	CDD:280427	44/72 (61%)
Rfx6	XP_006256506.2	RFX_DNA_binding	49..122	CDD:396712	44/72 (61%)
Rfx6	XP_006256506.2	PTZ00395	<582..>688	CDD:185594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278246at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X291
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920