Protein Alignment Rfx and Rfx1

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: NP_001420909.1
• Gene: Rfx1 / 288906
• RGDID: 1306574
• Length: 1074
• Species: Rattus norvegicus
• Alignment Length: 1023
• Identity: 369/1023 - (36%)
• Similarity: 489/1023 - (47%)
• Gaps: 219/1023 - (21%)

  Fly     7 PQRQFILSTRSAIVDATSPPEDSAEEQQQLTVEVESATNGVITNSTTSPPPHAEQFEFCT--EDG 69
            ||.|::...:|. ...|.||    ..|:|...|:.:|. .....:|.:|.|.|:|:...|  |..
  Rat    44 PQPQYVTELQSP-QPQTQPP----GSQKQYVAELPAAP-APSQPATPAPSPVAQQYIVVTVSEGA 102

  Fly    70 VVVSATLED-----------VMTQVKLFPLLQNCQLLQKKLVDEDDDSTGVGATDADQLEVISV- 122
            :..|.|:.:           |.|||     :|..|..|::|:.:.......|.....||..|.|
  Rat   103 MRASETVSEASPSSTASQTGVPTQV-----VQQVQGTQQRLLVQASVQAKPGHVSPLQLTNIQVP 162

  Fly   123 --VLPMD------------------AEDSTSDAHLHG-----HVVNSSSDTMGTITTTEPNGTTV 162
              .||..                  ...||...|...     ...||:|.|.||     |.||
  Rat   163 QQALPTQHLVVQSPAPGSKGGQVSLTVHSTQQVHSAPERSPVQANNSTSKTAGT-----PAGT-- 220

  Fly   163 THSIPIHSMADLAAIKDGVDLAQQVANGQVTVVQTTEDDDGTPFITVTVSGQEQNYQVQYVDSEL 227
            ...:.:||      ::..|.:.|     :.:|||.|......|...:||.|.:..:..|......
  Rat   221 VQQLQVHS------VQQSVPVTQ-----ERSVVQATPQTKAGPVQQLTVQGLQPVHVAQESSGSQ 274

  Fly   228 YHSNSSQTQMTYPFCPVGD---YQGNGQTAYYSTTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEG 289
            :.:..::.|.|.|..|...   ..|.|...       .|.....|......|     |...||:.
  Rat   275 FPARKAEQQETRPTPPPEPPPRPPGPGPAC-------CGEALQLGSEQQPPH-----YEPGVEQW 327

  Fly   290 ILLNG---------------------SAHSLSQSQSQSHGRDS------------------PHSL 315
            :.|.|                     ||.:....:.:.|....                  ||..
  Rat   328 VELVGVLPPHLLLPQQRVVFEPQPGLSARASPDLRVRIHRMPQVLVFGTALKVQQLPQVPVPHVY 392

  Fly   316 T-----VSSRDWERDADRVNGTNRHWVQEVAYIQ-------EAQST-PQTPTSTTTTHSASGGSL 367
            :     |...|....|..:..:...:.:...|.|       ||..| .|..|..|:...||.||:
  Rat   393 SSQVQYVEGGDASYTASAIRSSTYQYPETPIYTQTAGTSYYEASGTAAQVSTPATSQTVASSGSV 457

  Fly   368 ---------------------------------GTGGGGASPDSDQSALGS-------------- 385
                                             |:||||.......|..|:
  Rat   458 PMYVSGSPIVASSSSSEAGASNSSVGAGGNGGGGSGGGGGGSSGGGSGAGTYVIQGGYMLGNASQ 522

  Fly   386 ----SNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGL 446
                :.:.:.||::||..|||||:||||||||||.||:.||.|.||||||||||||||||||.||
  Rat   523 SYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGL 587

  Fly   447 RTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAG 511
            |||||||||||||||||:|||..|.| .:.|:|:|.:|....|.|..........|..|
  Rat   588 RTRRLGTRGNSKYHYYGLRIKASSPL-LRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGV------ 645

  Fly   512 QLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSE-LTLED 575
                :||:..|   :.|.|....:.:.:.|:   |:: |.:.:||.|..::|......| :...|
  Rat   646 ----ANGVAVG---QQSTGLSDISAQVQQYQ---QFL-DASRSLPDFAELDLQGKVLPEGVGPGD 699

  Fly   576 VDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEE----------EKYLSKT 630
            :..|:.|||||||:.:|.::||:|..||.|.:.|||    .||.:..|          ||.|.:.
  Rat   700 IKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWR----YNLSQPNEAPPLAVHDEAEKRLPRA 760

  Fly   631 KLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVP 695
            .|.||.....|.::.:..|...||..|:::||||||.||:|||||||||||:||.||..:|:.:|
  Rat   761 SLVLLSKFQPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIP 825

  Fly   696 EQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQ 760
            |::.::|.:|..||.||||||||||||||||||||||.|||:|||||||||||.||||||:||.:
  Rat   826 EEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCR 890

  Fly   761 CAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMI 825
            |...||||||.|||..||||:||||||:||..||...::.|.|...:.:||:.|||||||||||:
  Rat   891 CEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSSGFPKAAKLFLLKWSFYSSMV 955

  Fly   826 IRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICE 873
            |||||||||:|||||||||||:||||:||:||::|:|:.:|.|||:.|
  Rat   956 IRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGE 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	63/75 (84%)
Rfx1	NP_001420909.1	RFX1_trans_act	214..467	CDD:461362	52/282 (18%)
		RFX_DNA_binding	532..609	CDD:460512	63/76 (83%)