DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rfx and RFX6

DIOPT Version :9

Sequence 1:	NP_001247023.2	Gene:	Rfx / 41266	FlyBaseID:	FBgn0020379	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_775831.2	Gene:	RFX6 / 222546	HGNCID:	21478	Length:	928	Species:	Homo sapiens

Alignment Length:	696	Identity:	197/696 - (28%)
Similarity:	294/696 - (42%)	Gaps:	174/696 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 QTAYYSTTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGRDSPHSLT 316
            :|.|.:..||.|  ...||...| ....||..|..|  :.||....|..:..:.:|  ||.
Human    43 ETVYLAAEGQPG--GEQGGGEKG-EDPELPGAVKSE--MHLNNGNFSSEEEDADNH--DSK---- 96

  Fly   317 VSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGASPDSDQS 381
                  .:.||:             |:.:.::..|
Human    97 ------TKAADQ-------------YLSQKKTITQ------------------------------ 112

  Fly   382 ALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGL 446
            .:....|....|::||..||...:||.|||..||.||:..|.:.||||..||:|||.||..|..|
Human   113 IVKDKKKQTQLTLQWLEENYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLL 177

  Fly   447 RTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAG 511
            .||||||||:||||||||.||..|              |.|.....|.|         :|..:..
Human   178 TTRRLGTRGHSKYHYYGIGIKESS--------------AYYHSVYSGKG---------LTRFSGS 219

  Fly   512 QLTGSNGLGGGHGQRHSNGTKKHTFKPE-------TYEACIQYIGDGTSALPSFPPIELNHSFNS 569
            :|...    ||..:::|..:|..|..||       .|:.||
Human   220 KLKNE----GGFTRKYSLSSKTGTLLPEFPSAQHLVYQGCI------------------------ 256

  Fly   570 ELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTKLYL 634
              :.:.|||...:|:.||:..||..:|..|..::..|..||:...::.|...|....:.     :
Human   257 --SKDKVDTLIMMYKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIID-----I 314

  Fly   635 LCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLA 699
            .|.|          |...|:...||:||..::.:|.:|...|||||||.|.|:..|:..:||.|.
Human   315 FCVC----------DSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALT 369

  Fly   700 QIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQA--------- 755
            ..|...|..|..:|:|.||..||||.||..|.:...::.|:||:.|||.:::..||
Human   370 DKKIPIVRRFVSSLKRQTSFLHLAQIARPALFDQHVVNSMVSDIERVDLNSIGSQALLTISGSTD 434

  Fly   756 ----AWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAM---EEYNGKPTYARAARQ 813
                .:....:..|.|.|    |..|::.:::|.:..||..|||..:   .:.||: :..:.|:.
Human   435 TESGIYTEHDSITVFQEL----KDLLKKNATVEAFIEWLDTVVEQRVIKTSKQNGR-SLKKRAQD 494

  Fly   814 FLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICERMKKD 878
            |||||||:.:.::.:|||.:|||||||||||:|.|||:...:|.:....::: .:..:.::..|:
Human   495 FLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQ-ELQNLLDKYMKN 558

  Fly   879 MDFEFECQFAYITSDTEHQTTPSSA-----SSGGDVGNEAKRLKQE 919
            .|          .|......:|||.     :.|..|.::|  :|.|
Human   559 SD----------ASKAAFTASPSSCFLANRNKGSMVSSDA--VKNE 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	393..466	CDD:280427	44/72 (61%)
RFX6	NP_775831.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..98		16/64 (25%)
		RFX_DNA_binding	124..197	CDD:280427	44/72 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278246at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X291
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920