DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rfx and Rfx3

DIOPT Version :9

Sequence 1:	NP_001247023.2	Gene:	Rfx / 41266	FlyBaseID:	FBgn0020379	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_001347287.1	Gene:	Rfx3 / 19726	MGIID:	106582	Length:	790	Species:	Mus musculus

Alignment Length:	841	Identity:	351/841 - (41%)
Similarity:	449/841 - (53%)	Gaps:	205/841 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 SSDTMGTITTTEPNGTTVTHSIPIHSMADLAAIKDGVDLAQQV-ANGQVTVVQTTEDDDGTPFIT 208
            |...|.|..|....|:|||...   |:|..||:.  ..:.||| ...||..|||.:
Mouse    38 SETIMQTSETGSDTGSTVTLQT---SVASQAAVP--TQVVQQVPVQQQVQQVQTVQ--------- 88

  Fly   209 VTVSGQEQNY---QVQYVD-SELYHSNSSQTQMTYPFCPVGDYQGNGQTAYYSTTG--------- 260
                 |.|:.   |||||: |:..::|.:....|||:.....|..|....|:.|.|
Mouse    89 -----QVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVV 148

  Fly   261 -----------QYGTT-----SSAGGSSNGAHSTTLPYLVPVEEGILLNGSAHSLSQSQSQSHGR 309
                       |.|.|     ||:||:          ||:    |..:..|.||::.:.     |
Mouse   149 SSHSMVGTGGIQMGVTGGQLISSSGGT----------YLI----GNSMENSGHSVTHTT-----R 194

  Fly   310 DSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGTGGGGA 374
            .||                            |.|:.|..|.| .:...:||.:|
Mouse   195 ASP----------------------------ATIEMAIETLQ-KSDGLSTHRSS----------- 219

  Fly   375 SPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLI 439
                          :.::.::||..|||||:|||||||||||||::||.||||:|||||||||||
Mouse   220 --------------LLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLI 270

  Fly   440 RSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPS-------------- 490
            ||:|.|||||||||||||||||||||:||.|.|| :..:|.|.:|....|.
Mouse   271 RSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLN-RLQEDMQYMAMRQQPMQQKQRYKPMQKVDG 334

  Fly   491 -SDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDGTSA 554
             :||..|.|.....||..:...|           .|.|.                 |:: |.:.|
Mouse   335 VADGFTGSGQQTGTSVEQTVIAQ-----------SQHHQ-----------------QFL-DASRA 370

  Fly   555 LPSFPPIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRAS------ 613
            ||.|..:|:: |.....|.||:.:.:.|||||||:.||.|:||:|:.:|.|.:.|||.|
Mouse   371 LPEFGEVEIS-SLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPAD 434

  Fly   614 -----DNNNLDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALT 673
                 :::||.|.|..  |.|.||..||....:.|::...|:..||..|:::||||||.||:|||
Mouse   435 GTTITESSNLSEIESR--LPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALT 497

  Fly   674 QAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQ 738
            ||||||||:||.||..:|..:|:::.|.|.:|||||.||||||||||||||||||||||.:||:|
Mouse   498 QAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQ 562

  Fly   739 MLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNG 803
            ||||||||||.||||||:||.||...:|||||:|||..|||||:|||||:||..|:..|::.|.|
Mouse   563 MLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEG 627

  Fly   804 KPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAI 868
            :|::.:|||||||||||||||:|||||||||:|||||||||||:||||||||||::|:...:|.|
Mouse   628 RPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQVTGETPI 692

  Fly   869 AVICE----------RMKKDMDFEFECQFAYITSDTEHQTTPSSASSGGDVGNEAKRLKQE 919
            ||:.|          .:.||...|.|       |:|:.....||..       .|||.|.|
Mouse   693 AVMGEFGDLNAVSPGNLDKDEGSEVE-------SETDEDLDDSSEP-------RAKREKTE 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	393..466	CDD:280427	60/72 (83%)
Rfx3	NP_001347287.1	RFX1_trans_act	45..178	CDD:368012	42/161 (26%)
Rfx3	NP_001347287.1	RFX_DNA_binding	225..297	CDD:367002	60/71 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850230
Domainoid	1	1.000	384	1.000	Domainoid score	I814
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7917
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1220
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278246at33208
OrthoFinder	1	1.000	-	-		FOG0000699
OrthoInspector	1	1.000	-	-		otm43972
orthoMCL	1	0.900	-	-		OOG6_102578
Panther	1	1.100	-	-	LDO	PTHR12619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1282
SonicParanoid	1	1.000	-	-		X291
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930