DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rfx and daf-19

DIOPT Version :9

Sequence 1:	NP_001247023.2	Gene:	Rfx / 41266	FlyBaseID:	FBgn0020379	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_001022140.1	Gene:	daf-19 / 174577	WormBaseID:	WBGene00000914	Length:	805	Species:	Caenorhabditis elegans

Alignment Length:	837	Identity:	254/837 - (30%)
Similarity:	368/837 - (43%)	Gaps:	228/837 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 DAEDSTSDAHLHGHVVNSSSDTMGT------ITTTEPNGTTVTHSIPIH---------SMADLAA 176
            |::..:.:.|   :.:::.|.:.||      ....:||...:..|:|:.         ::.|.:.
Worm    83 DSKSLSKETH---NTISTRSSSSGTPRKKMEPEDVKPNIKMLKKSLPVSFQCSNLNDGTVGDASV 144

  Fly   177 IKDGVDL---AQQVANG-----QVTVVQ-TTEDDDGTPFITVTVSGQEQNY-QVQYVDSELYHSN 231
            :.|...:   :..||.|     ::.|:| :|:|.:||        .:|.:| |::|       .|
Worm   145 MLDPTKISLHSSSVAYGEESQDEMEVIQHSTDDPNGT--------REEFDYNQIEY-------GN 194

  Fly   232 SSQTQMTYP-FCPVGDYQGNGQTAYYSTTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEGILLNGS 295
            :.....||. :.|..:|     ..||    ||.....:....|.      |||||
Worm   195 AVTPNGTYTLYAPDSNY-----APYY----QYSNNMQSSPQDNA------PYLVP---------- 234

  Fly   296 AHSLSQSQSQSHGRDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTH 360
                                                                 .||:|.|.
Worm   235 -----------------------------------------------------APQSPVSI---- 242

  Fly   361 SASGGSLGTGGGGASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEH 425
                           .|:|...|.::.:.:.||:.||..|||..:| ||||..||:||.:||:||
Worm   243 ---------------DDADSINLPNNQRASPATVNWLFENYEIGEG-SLPRCELYDHYKKHCAEH 291

  Fly   426 KLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLAAGYGPS 490
            :::|||||||||||||||..|:||||||||||||||||||:|..|.|:|......|::...|.|
Worm   292 RMDPVNAASFGKLIRSVFHNLKTRRLGTRGNSKYHYYGIRLKDSSTLHSMQHPQPQIIQNTYTP- 355

  Fly   491 SDGTGGPGSGPMVSVTSSTAGQLTG---------------SNGLGGGH------------GQRHS 528
                  |...|.....:.|..|:..               .|......            .|:..
Worm   356 ------PMQLPQRDAYADTVNQVAAIKYMDVEIPDKRARKDNSSSSSSCRDSVSPCMDLPAQQTI 414

  Fly   529 NGTKKHTFKPETYEAC-------IQYI-------GDGTSALPSFPPIELNHSFNSELTL------ 573
            ..|..|:..|.|.:..       :.|:       ..|...||..|       |..:..|
Worm   415 QHTPVHSVIPSTQQPAPLHNNNVVSYVVTESDKAAMGKIDLPIVP-------FPDKDALMATIGF 472

  Fly   574 -------EDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRASDNNNLDECEEEKYLSKTK 631
                   |::::...:|...|...|..:.|::|.:||.....||  |.|..:|         :..
Worm   473 RKLGVGEEELNSLIDIYEILCREILALIKNIDFASVEDTWSKFW--SGNFGVD---------RDH 526

  Fly   632 LYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRS-IPNALTQAIRNFAKNLEIWLCESML--G 693
            :..||...:||.::.|||...||..||.:||:||.| :...:||..|.||||::::|.:|::  .
Worm   527 ISALCTLDQVQDYIIEVDLALYQTIVDTLIPNVLLSELSTGMTQTCRTFAKNIDVYLRKSLMLAN 591

  Fly   694 VPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWV 758
            :.|...:.|..|:....|.|:|||||||||.|:|.||....|:.||..|..|||.:.|.:||.|:
Worm   592 LGEFFVKKKIQAIKYLQQGLKRYTSLNHLAHASRGVLMKPEQVQQMYQDYIRVDINTVHQQAGWI 656

  Fly   759 SQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKP--TYARAARQFLLKWSFY 821
            ..|...:|..:.:.||..||:.|::|.||.||:.:|:..:.:|:.||  ..|...:||||.||||
Worm   657 CGCDSVMVHHVNNAFKHNLQRMSAMEVWAEWLESIVDQVLAKYHDKPANVIANVGKQFLLNWSFY 721

  Fly   822 SSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICERMKKD 878
            :||||||||||||.|||||.|||||.|:||:||:|.|||:|..:..|.||  |..||
Worm   722 TSMIIRDLTLRSAMSFGSFTLIRLLADDYMYYLIESKIAKAGKQQLITVI--RADKD 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	393..466	CDD:280427	52/72 (72%)
daf-19	NP_001022140.1	RFX_DNA_binding	257..332	CDD:280427	53/75 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167388
Domainoid	1	1.000	229	1.000	Domainoid score	I1401
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7917
Inparanoid	1	1.050	328	1.000	Inparanoid score	I1451
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D278246at33208
OrthoFinder	1	1.000	-	-		FOG0000699
OrthoInspector	1	1.000	-	-		oto18039
orthoMCL	1	0.900	-	-		OOG6_102578
Panther	1	1.100	-	-	LDO	PTHR12619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1282
SonicParanoid	1	1.000	-	-		X291
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.930