Protein Alignment Rfx and Rfx

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: XP_061497414.1
• Gene: Rfx / 1278772
• VectorBaseID: AGAMI1_007158
• Length: 962
• Species: Anopheles gambiae
• Alignment Length: 1042
• Identity: 456/1042 - (43%)
• Similarity: 558/1042 - (53%)
• Gaps: 266/1042 - (25%)

  Fly     1 MTTRLAPQRQFILSTRSAIVDATS---------PPEDSAEEQQQLTV----EVESATNG------ 46
            |.||||.||.||     |::.|.|         |..:......|..|    |.|...||
Mosquito     1 MATRLAAQRNFI-----AVIPAVSGGSASVTVEPAGEGGTTAVQKPVTEPAETEGTANGTSQTTA 60

  Fly    47 -VITNSTTSPPP---------HAEQFEFCT----------EDGVVVSATLEDVMTQVKLFPLLQN 91
             |:|.|..|..|         ::.|....|          ..|.:|...|  :.....:..:|.|
Mosquito    61 EVVTVSVASSSPTVMASRPGANSTQLPTITIAGGGLKNGNAKGALVPTAL--LANNSNIMNILSN 123

  Fly    92 C------QLLQKK------------LVDEDDDSTGVGATDADQLEVISVVLPMDAEDSTSDAHLH 138
            .      |::|:|            ||..:||:.             ||.:..|.|.....:..:
Mosquito   124 ANGLSLQQIIQQKKIVINTNGTLIDLVQLNDDNE-------------SVEIKADGEKLLDSSTAN 175

  Fly   139 GHVVNSSSDTMGTITTTEPNGTTVTHSIPIHSMADLAAIKDGVDLAQQVANGQVTVVQTTEDDDG 203
            ..|.:.||.:..|...|.                                  ||.|||:  ...|
Mosquito   176 ESVESGSSGSEATADETP----------------------------------QVAVVQS--PGGG 204

  Fly   204 TP-FITVTVSGQE----QNYQVQYVDSELYH-SNSSQTQMTYPFCPVGDYQGNG---QTAYYSTT 259
            || :||||||..:    |:..||||||::|: |...|||||||...||||..||   |..||:|:
Mosquito   205 TPQYITVTVSSPDSVPNQHTYVQYVDSDMYNTSGQGQTQMTYPVYTVGDYGTNGQQQQQQYYTTS 269

  Fly   260 GQYGT---------TSSAG-GSSNGAHST-TLP-----------------------YLVPVEEGI 290
            |.|||         |.:.| |:|||..:| |.|                       |:|||:|.:
Mosquito   270 GAYGTAGAGTGSTHTDTTGNGTSNGTGTTGTGPNGVNGSVSSGNGGSAAGNANQQQYIVPVDESV 334

  Fly   291 LL----NGSAHSLSQSQSQSHGRDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQ 351
            ||    :|:...:.|.||.|    ||.::|          |..:..:.|....|.  ||..|.|
Mosquito   335 LLGSAGSGNTSGVQQQQSDS----SPQNMT----------DVASYLHAHQTASVG--QELDSAP- 382

  Fly   352 TPTSTTTTHSASGGSLGTGGGGASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYN 416
                 ..||:|                         ::..||:.||..|||||||||||||||||
Mosquito   383 -----NMTHAA-------------------------RVLPATVSWLMENYETADGVSLPRSTLYN 417

  Fly   417 HYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLL--------- 472
            |||.||:|:||:.|||||||||||||||||||||||||||||||||||||||.|.|
Mosquito   418 HYMWHCNENKLDAVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPTSPLVHAIECKPQ 482

  Fly   473 --------------NSQAMDDKQMLAAGYGPSSD---------------------------GTGG 496
                          :.|.:.....|..|.|...:                           |.||
Mosquito   483 HGSGGVGGLGGMVGHHQQLGGSNGLGGGNGTGGNNGMHGHAGGGNHANGLHGSNGSSMAHGGGGG 547

  Fly   497 PGSGPMVSVTSSTAGQLTGSNGLGGGHG--QRHSNGTKKHTFKPETYEACIQYIGDGTSALPSFP 559
            .|.|....:.....|...|..|.|||||  ..|..| ||::||.|..|:|.||:||...|:|.||
Mosquito   548 GGGGGGGHLQQGVVGGANGGGGSGGGHGMAMHHGRG-KKNSFKAEMPESCAQYLGDPNGAIPQFP 611

  Fly   560 PIELNHSFNSELTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRA-SDNNNLDECEE 623
            .|::.|....::|:|||||.|.:||||||:||||:|||:||.:|.|.|:|||| ::|||.|||||
Mosquito   612 IIDMIHPLPDDITMEDVDTLRSIYREHCEAFLDAILNLDFNMIESLWREFWRAENNNNNGDECEE 676

  Fly   624 EKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLC 688
            ||||||.|||||..|..||:||:.||.||||:.|||:||||||.||..|||||||||||||.||.
Mosquito   677 EKYLSKQKLYLLTQCEPVQEFVKHVDLQFYQSMVDVLIPDVLRPIPTGLTQAIRNFAKNLENWLT 741

  Fly   689 ESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQE 753
            .:|.|.||.:..||.|||:||.|||||||||||||||||||||||.||:|||||||||||.||||
Mosquito   742 SAMGGCPEPIVAIKLSAVAAFGQTLRRYTSLNHLAQAARAVLQNGTQIAQMLSDLNRVDFRNVQE 806

  Fly   754 QAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKW 818
            ||:|:.||..|||||||:|||||||||::|||||.|||.||:.|::||.|||::..|||||||||
Mosquito   807 QASWICQCDTAVVQRLENDFKAALQQQNTLEQWAGWLQNVVDDALQEYRGKPSFVHAARQFLLKW 871

  Fly   819 SFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIAVICER-----MKKD 878
            ||||||:|||||||||.|||||||||||:|||||:::|||:|:|.:.|.|||:.|:     ::.|
Mosquito   872 SFYSSMVIRDLTLRSAGSFGSFHLIRLLYDEYMFFIIEHKVAKATNTTPIAVMGEKINSRPVQDD 936

  Fly   879 MD 880
            :|
Mosquito   937 LD 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	66/75 (88%)
Rfx	XP_061497414.1	None