DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rfx and rfx2

DIOPT Version :9

Sequence 1:	NP_001247023.2	Gene:	Rfx / 41266	FlyBaseID:	FBgn0020379	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	XP_012810994.2	Gene:	rfx2 / 100144734	XenbaseID:	XB-GENE-991774	Length:	724	Species:	Xenopus tropicalis

Alignment Length:	784	Identity:	322/784 - (41%)
Similarity:	427/784 - (54%)	Gaps:	146/784 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 MDAEDSTSDAHLHGHVVNSSSDTMGTITTTEPNGTTVTHSIPIHSMADLAAIKDGVDLAQQVANG 190
            |...||.||           |.|...:.|:......|...:|......|:.....   |.:.|:|
Frog     1 MQNSDSGSD-----------SATSVALRTSASAQAPVVQPVPASQQRSLSQASGS---APKGAHG 51

  Fly   191 Q-VTVVQTTEDDDGTPFITVTVSGQEQNY--QVQYVDSELYHSNSS-QTQMTYPFCPVGDYQGNG 251
            | ::|.:..:       :...|...:..|  |||||:.:..::|.: :|..:|          |.
Frog    52 QGISVPRAHQ-------LQQQVQTVQHVYPAQVQYVEGDTVYTNGAIRTAYSY----------NA 99

  Fly   252 QTAYYSTTGQYGTTSSAGGSSNGAHSTTL---PYLVPVEEGILLNGSAHSLSQSQSQS------- 306
            :...|:.:.......|.||   ||..||:   |..:|....:   |.|..:|.||..|
Frog   100 EAQIYAPSSGSSYFDSQGG---GAQVTTVVSSPTAIPSHSMV---GIAMDVSGSQIISSSGAYLI 158

  Fly   307 HG--RDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQSTPQTPTSTTTTHSASGGSLGT 369
            ||  .:|.|:.:.:||.:....:..             |:..|.     ....|:|.:|
Frog   159 HGGLENSRHTPSHTSRTFPATLEMA-------------IENLQK-----NEGITSHKSS------ 199

  Fly   370 GGGGASPDSDQSALGSSNKIASATIKWLSRNYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAAS 434
                               :.::.::||..|||||:|||||||:|||||::||.:|||:||||||
Frog   200 -------------------LLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQDHKLDPVNAAS 245

  Fly   435 FGKLIRSVFSGLRTRRLGTRGNSKYHYYGIRIKPGSLLNSQAMDDKQMLA---------AGYGPS 490
            |||||||||.|||||||||||||||||||||:||.|.|| :..:|.|.:|         ..|.|:
Frog   246 FGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLN-RLQEDTQYMAIRQQPIHQKQRYRPA 309

  Fly   491 S--DGTG--GPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSNGTKKHTFKPETYEACIQYIGDG 551
            .  ||.|  ...|....|...|.|.|           .|.|.                 |:| |.
Frog   310 QKMDGMGENTANSSQHTSPEQSVAAQ-----------SQHHQ-----------------QFI-DT 345

  Fly   552 TSALPSFPPIELNHSFNSE-LTLEDVDTFRGLYREHCESFLDAVLNLEFNTVEFLLRDFWRAS-- 613
            ....|.||..:|.:....| :|:.|:...:.:||.|||:.:|.|:||:|..:|.|.:.||.:.
Frog   346 AHVFPDFPAPDLGNVLLPEGITMTDIKNLQLMYRRHCEATIDVVMNLQFQYIEKLWQAFWNSKPS 410

  Fly   614 --DNNN--LDECEEEKYLSKTKLYLLCHCAEVQKFVREVDYQFYQNTVDVIIPDVLRSIPNALTQ 674
              |.:|  ..|.|:|..:.|.||.:||....:.:::|..|:..||..|:::||||||.:|:.|||
Frog   411 SPDGSNPMNSEDEQEPIIPKDKLMVLCKYEPIMRWMRNCDHILYQALVEILIPDVLRPVPSTLTQ 475

  Fly   675 AIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYTSLNHLAQAARAVLQNGAQISQM 739
            |||||||:||.||..:|...|:|:...|...||||.||||||||||||||||||||||.:||:||
Frog   476 AIRNFAKSLEGWLTNAMCDFPQQIVHAKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQM 540

  Fly   740 LSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSSLEQWASWLQLVVESAMEEYNGK 804
            |||||||||.||||||:||.||...:||:||.|||..|||||||:|||:||..||...::.:.|.
Frog   541 LSDLNRVDFANVQEQASWVCQCEEGMVQKLEQDFKLTLQQQSSLDQWANWLDNVVTQVLKPHEGS 605

  Fly   805 PTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLFDEYMFYLVEHKIAEAQDKTAIA 869
            |::.:|||||||||||||||:|||||||||:|||||||||||:||||||||||::|:|..:|.||
Frog   606 PSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIA 670

  Fly   870 VICE 873
            |:.|
Frog   671 VMGE 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	393..466	CDD:280427	59/72 (82%)
rfx2	XP_012810994.2	RFX1_trans_act	4..158	CDD:398335	42/190 (22%)
rfx2	XP_012810994.2	RFX_DNA_binding	205..277	CDD:396712	59/71 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I786
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	529	1.000	Inparanoid score	I1199
OMA	1	1.010	-	-		QHG49084
OrthoDB	1	1.010	-	-		D278246at33208
OrthoFinder	1	1.000	-	-		FOG0000699
OrthoInspector	1	1.000	-	-		otm49147
Panther	1	1.100	-	-	O	PTHR12619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1282
SonicParanoid	1	1.000	-	-		X291
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110