Protein Alignment Rfx and rfx1a

DIOPT Version :10

• Sequence 1: NP_001247023.2
• Gene: Rfx / 41266
• FlyBaseID: FBgn0020379
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: XP_068071497.1
• Gene: rfx1a / 100038773
• ZFINID: ZDB-GENE-070424-94
• Length: 1015
• Species: Danio rerio
• Alignment Length: 1058
• Identity: 383/1058 - (36%)
• Similarity: 512/1058 - (48%)
• Gaps: 241/1058 - (22%)

  Fly     2 TTRLAPQRQFI--LSTRSAIVDA------TSPPEDSAEEQQQLTVEVESATNGVITNSTTSPPPH 58
            |....|| ||:  |.|..|...|      |:||...|::.|           .:.....|..||.
Zfish    30 TVTAGPQ-QFLAELQTTGATPSAAPPTGRTTPPTSQAQKSQ-----------AIAQAPPTQAPPT 82

  Fly    59 AEQFEFCTEDGVVVSATLEDVMTQVKLFPLLQNCQLLQKKLV-----------DEDDDSTGVGAT 112
            ..|:         |:|.::...||      ..|.|...:.:|           |...||:...|
Zfish    83 QTQY---------VTAEIQSSPTQ------SSNAQNTPQYIVVTVTEGSLHSSDSVSDSSPPAA- 131

  Fly   113 DADQLEVISVVLPMDAEDSTSDAHLHGHVVNSSSDTMGTITTTEPNGTTV--------------- 162
                  |:...:|.........|.... ||.::|.|..|...|:.|.|::
Zfish   132 ------VVQTGVPTQVVQQVQSAQQRS-VVQATSQTTKTEPGTQLNVTSLQSVHLTQESTFFREG 189

  Fly   163 ------------------------THSIPIHSMADLAAIKDG------VDLAQQVANGQVTVVQT 197
                                    .|:.|.......|::..|      |.:|....:..:.:|..
Zfish   190 ESKLRRQRQIEDWLEHRPAVVLLEKHTNPFGESLSYASVDGGLMDFSPVPVAYSPVSFSLPLVAV 254

  Fly   198 TEDDDGTPFITVTVSG--------------QEQ----------NYQVQYVD-SELYHSNSSQTQM 237
            ..:.||..:.:..|..              |:|          ..|||||: .|..::.|:....
Zfish   255 GWETDGVSYTSAPVPDVQSFLYEMSSAHRVQQQLQQVPVQHVYTNQVQYVEGGEANYTTSTIRSS 319

  Fly   238 TYPFCPVGDYQGNGQTAYY--STTGQYGTTSSAGGSSNGAHSTTLPYLVPVEEG----------- 289
            ::|:.         :|..|  |:.|||...:.|.||.  |.|...|..|.|..|
Zfish   320 SFPYT---------ETPLYTQSSAGQYYEATPASGSE--AASPGTPLTVSVTSGSPGVPMFVAGT 373

  Fly   290 --ILLN-----GSAHSLSQSQSQSHGRDSPHSLTVSSRDWERDADRVNGTNRHWVQEVAYIQEAQ 347
              |:.|     ||..:...:.:.:....|..|           |...||:...:|.:..|:
Zfish   374 GQIVANPTTAAGSGVTAVVAAAGTAANGSGES-----------AGEANGSGGSYVIQGGYM---- 423

  Fly   348 STPQTPTSTTTTHSASGGSLGTGGG-----GASPDSDQSALGSSNKIASA--------TIKWLSR 399
                       ......||.|.|.|     .|||.:.....|..|.:.||        .::||..
Zfish   424 -----------LAGTGSGSSGNGHGYPHPTRASPATVSINEGEDNSVPSADKKLSSGPQVQWLLD 477

  Fly   400 NYETADGVSLPRSTLYNHYMQHCSEHKLEPVNAASFGKLIRSVFSGLRTRRLGTRGNSKYHYYGI 464
            |||||:||||||||||.||:.||.|.||||||||||||||||||.|||||||||||||||||||:
Zfish   478 NYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGL 542

  Fly   465 RIKPGSLLNSQAMDDKQMLAAGYGPSSDGTGGPGSGPMVSVTSSTAGQLTGSNGLGGGHGQRHSN 529
            |||..|.| .:.|:|:|.||....|.|.   .....|:..|...|.|.   |:|.|....|:.|:
Zfish   543 RIKASSSL-LRLMEDQQHLAMRQQPFSQ---KQRLKPVQKVEGITNGM---SSGSGQQQQQQQSS 600

  Fly   530 GTKKHTFKPETYEACIQYIGDGTSALPSFPPIELNHSFNSE-LTLEDVDTFRGLYREHCESFLDA 593
            |....:.:.:.|:   |:: |.:.|||.||.::|......| :.||.:.:|:.|||||||:.||.
Zfish   601 GLSDISTQVQQYQ---QFL-DASKALPEFPDVDLQGKALPEGIELEHLKSFQLLYREHCEAILDV 661

  Fly   594 VLNLEFNTVEFLLRDFWRASDNNNLDEC------EEEKYLSKTKLYLLCHCAEVQKFVREVDYQF 652
            ::||:|..||.|.:.|||.|:|...|..      |.||.|.||.|.:||....|.::.|:.|...
Zfish   662 MVNLQFPLVETLWKTFWRFSENQAGDSATLAVHDESEKRLPKTCLVILCKYEPVLRWSRDCDNTL 726

  Fly   653 YQNTVDVIIPDVLRSIPNALTQAIRNFAKNLEIWLCESMLGVPEQLAQIKTSAVSAFCQTLRRYT 717
            ||..|:::||||||.||:|||||||||||:||.||..:|:.:||::.::|.::.|||.|||||||
Zfish   727 YQGLVEMLIPDVLRPIPSALTQAIRNFAKSLESWLTNAMVNIPEEMVRVKVTSASAFAQTLRRYT 791

  Fly   718 SLNHLAQAARAVLQNGAQISQMLSDLNRVDFHNVQEQAAWVSQCAPAVVQRLESDFKAALQQQSS 782
            |||||||||||||||.|||:|||||||||||.||||||:||.:|...||||||.|||..||||:|
Zfish   792 SLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKLTLQQQNS 856

  Fly   783 LEQWASWLQLVVESAMEEYNGKPTYARAARQFLLKWSFYSSMIIRDLTLRSASSFGSFHLIRLLF 847
            |||||:||..||...::.|.......:||:.|||||||||||:|||||||||:|||||||||||:
Zfish   857 LEQWAAWLDGVVSQVLKPYQSSAALPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLY 921

  Fly   848 DEYMFYLVEHKIAEAQDKTAIAVIC-----------------ERMKKDMDFEFECQFAYITSDTE 895
            ||||:||:||::|:|:.:|.|||:.                 |..:::.:.:.|||...:.||.
Zfish   922 DEYMYYLIEHRVAQAKGETPIAVMGEFASLGRSLNPLDPDKEEEEEEEEESDDECQELSLQSDV- 985

  Fly   896 HQTTPSSASSGGDVGNEA 913
                       |.:|:|:
Zfish   986 -----------GAMGDES 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rfx	NP_001247023.2	RFX_DNA_binding	392..468	CDD:460512	62/83 (75%)
rfx1a	XP_068071497.1	RFX1_trans_act	128..385	CDD:461362	49/275 (18%)
		RFX_DNA_binding	472..546	CDD:460512	61/73 (84%)