DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jumu and Foxk1

DIOPT Version :9

Sequence 1:	NP_524302.1	Gene:	jumu / 41265	FlyBaseID:	FBgn0015396	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_951031.2	Gene:	Foxk1 / 17425	MGIID:	1347488	Length:	719	Species:	Mus musculus

Alignment Length:	397	Identity:	95/397 - (23%)
Similarity:	154/397 - (38%)	Gaps:	87/397 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 PAQMKVSAGSMRRDQVMAHIPKQISVVTGTGTTAPATMATNSVLQRRNSSAVDAVRKDLVTELRK 246
            |||......::..:.....:|..::..|   |||||.:|..:...|::.....|..:....|...
Mouse    43 PAQPPPGPPALPAEPGPGPVPSTVATAT---TTAPALVAAAAASVRQSPGPALARLEGREFEFLM 104

  Fly   247 AQSSPVPNSLEELGKGKGSTLLNASVGATNTI--------------------------------K 279
            .|.|..      :|:......::.|:|.::.|                                :
Mouse   105 RQPSVT------IGRNSSQGSVDLSMGLSSFISRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRR 163

  Fly   280 LAPGI---GGLTFANSAAYQKLKQTSLV-KSPGGISPGAGSNMGLKREDSNKRGLQASTTPKSIA 340
            .||.:   ...||...:...|::.|||. |.....||              .|.|....:|..|
Mouse   164 GAPALQLPQQCTFRFPSTAIKIQFTSLYHKEEAPASP--------------LRPLYPQISPLKI- 213

  Fly   341 SAANSPHHQMQSNYS-LGSPS---SLSSSSASSPLGNVSNLVNIANNNTSG---AGSGLVKPLQQ 398
               :.|...::|..| :.||:   |:.:|..:||.|..|:......|.||.   |.....|...:
Mouse   214 ---HIPEPDLRSLVSPIPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTSDLQLAAEFAAKAASE 275

  Fly   399 KVKLPPVGSPFP----KPAYSYSCLIALALKNSRAGSLPVSEIYSFLCQHFPYFENAPSGWKNSV 459
            : :....|...|    ||.|||:.||..|:.:::...|.:|.||:.:.:|:||:..|..||:||:
Mouse   276 Q-QADASGGDSPKDESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSI 339

  Fly   460 RHNLSLNKCFEKIERPATNGNQRKGCRWAMNPDRINKMDEEVQKWSRK----------DPAAIRG 514
            |||||||:.|.|:  |.:.....||..|.::|....|:.|:..:..|:          .|.:.|.
Mouse   340 RHNLSLNRYFIKV--PRSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFRTPFGPLSSRS 402

  Fly   515 AMVYPQH 521
            |...|.|
Mouse   403 APASPTH 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jumu	NP_524302.1	Forkhead	411..499	CDD:278670	35/87 (40%)
Foxk1	NP_951031.2	Interaction with SIN3A and SIN3B. /evidence=ECO:0000269\|PubMed:10620510, ECO:0000269\|PubMed:22476904	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..67		4/23 (17%)
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269\|PubMed:22956541	81..406		82/351 (23%)
		FHA	<88..190	CDD:224630	14/107 (13%)
		FHA	96..189	CDD:238017	12/98 (12%)
		Forkhead	291..377	CDD:278670	35/87 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820