DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jumu and Foxc1

DIOPT Version :9

Sequence 1:	NP_524302.1	Gene:	jumu / 41265	FlyBaseID:	FBgn0015396	Length:	719	Species:	Drosophila melanogaster
Sequence 2:	NP_032618.2	Gene:	Foxc1 / 17300	MGIID:	1347466	Length:	553	Species:	Mus musculus

Alignment Length:	186	Identity:	58/186 - (31%)
Similarity:	86/186 - (46%)	Gaps:	35/186 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 MQSNYSLGSPSSLSSSSASSPLGNVSNLVNIANNNTSGAGSG-LVKPLQQKVKLPPV------GS 407
            ||:.||:.||:||   .....||...:....|   .:.||.| ...|....|...|.      ||
Mouse     1 MQARYSVSSPNSL---GVVPYLGGEQSYYRAA---AAAAGGGYTAMPAPMSVYSHPAHAEQYPGS 59

  Fly   408 -----------PFP----KPAYSYSCLIALALKNSRAGSLPVSEIYSFLCQHFPYFENAPSGWKN 457
                       |.|    ||.|||..||.:|::|:....:.::.||.|:...||::.:...||:|
Mouse    60 MARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQN 124

  Fly   458 SVRHNLSLNKCFEKIERPATNGNQRKGCRWAMNPDRINKMD-----EEVQKWSRKD 508
            |:|||||||:||.|:  |..:....||..|.::||..|..:     ...:::.:||
Mouse   125 SIRHNLSLNECFVKV--PRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKD 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jumu	NP_524302.1	Forkhead	411..499	CDD:278670	35/92 (38%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	1..51		16/55 (29%)
		FH	78..166	CDD:214627	35/89 (39%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250\|UniProtKB:Q12948	78..93		8/14 (57%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250\|UniProtKB:Q12948	168..176		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..326		2/6 (33%)
		Required for transcriptional inhibition. /evidence=ECO:0000250\|UniProtKB:Q12948	217..366
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..466
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	466..553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820